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Effects of pulmonary surfactant combined with noninvasive positive pressure ventilation in neonates with respiratory distress syndrome

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World Journal of Clinical Cases 2024年第23期12卷 5366-5373页

作者： Ze-Ning Shi Xin Zhang Chun-Yuan Du Bing Zhao Shu-Gang Liu Department of Pediatrics Army Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina Department of Anesthesiology Army Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina Department of Gynecology and Obstetrics Army Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Neonatal respiratory distress syndrome(NRDS)is one of the most common diseases in neonatal intensive care units,with an incidence rate of about 7%among ***,it is a leading cause of neonatal death in hospitals in *** main mechanism of the disease is hypoxemia and hypercapnia caused by lack of surfactant AIM To explore the effect of pulmonary surfactant(PS)combined with noninvasive positive pressure ventilation on keratin-14(KRT-14)and endothelin-1(ET-1)levels in peripheral blood and the effectiveness in treating *** Altogether 137 neonates with respiratory distress syndrome treated in our hospital from April 2019 to July 2021 were *** these,64 control cases were treated with noninvasive positive pressure ventilation and 73 observation cases were treated with PS combined with noninvasive positive pressure *** expression of KRT-14 and ET-1 in the two groups was *** deaths,complications,and PaO_(2),PaCO_(2),and PaO_(2)/FiO_(2)blood gas indexes in the two groups were *** operating characteristic curve(ROC)analysis was used to determine the diagnostic value of KRT-14 and ET-1 in the treatment of *** The observation group had a significantly higher effectiveness rate than the control *** was no significant difference between the two groups in terms of neonatal mortality and adverse reactions,such as bronchial dysplasia,cyanosis,and shortness of *** treatment,the levels of PaO_(2)and PaO_(2)/FiO_(2)in both groups were significantly higher than before treatment,while the level of PaCO_(2)was significantly *** treatment,the observation group had significantly higher levels of PaO_(2)and PaO_(2)/FiO_(2)than the control group,while PaCO_(2)was notably lower in the observation *** treatment,the KRT-14 and ET-1 levels in both groups were significantly decreased compared with the pre-treatment *** observation group had a reduction of KRT-14 and ET-

关键词： Pulmonary surfactant Non-invasive positive pressure ventilation Neonatal respiratory distress syndrome keratin-14 Endothelin-1

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