Prior Preterm Birth and Birthweight Below the 5 th Percentile are Independent Risk Factors for Recurrence of a Small for Gestational Age Neonate

作     者：Mor Svorai Barak Aricha Offer Erez Svorai Mor;Aricha Barak;Erez Offer

作者机构：School of MedicineFaculty of Health SciencesBen Gurion University of the NegevBeer Sheva 84101Israel Department of Obstetrics and GynecologySoroka University Medical CenterSchool of MedicineFaculty of Health SciencesBen Gurion University of the NegevBeer Sheva 84101Israel 

出 版 物：《Maternal-Fetal Medicine》 (母胎医学杂志（英文）)

年 卷 期：2020年第2卷第1期

页      面：28-33页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Fetal growth retardation Maternal outcome Neonatal outcome Recurrence Risk factor Small for gestational age 

摘      要：Objective::This study aimed to determine:(1)whether recurrent deliveries of a small for gestational age(SGA)neonate are associated with increased obstetrical or neonatal complications;(2)whether the risk factors that can predict small for gestational age(SGA)***::This study was based on Soroka Medical Center s Obstetrics electronic *** database consisted of 109022 women who had 320932 deliveries between the year *** study cohort included 6.8%(7368/109022)of these patients who gave birth to a singleton SGA neonate on their first delivery and had more than one *** study population was divided into two groups according to the outcome of the subsequent delivery:(1)women with sporadic SGA who delivered a non-SGA neonate(n=5416);(2)women with recurrent SGA(n=1952).SGA defined as birthweight10 th *** and neonatal complications were compared between the two *** regression was used to determine independent risk factors for SGA ***::The prevalence of birthweight5 th percentile was higher among the recurrent SGA group in the first delivery(P0.001).Bedouin ethnicity was more prevalent in the recurrent SGA group(P0.001).The rate of preterm delivery was higher in the first delivery of the recurrent SGA group(P=0.015).The sporadic SGA group had a higher rate of perinatal mortality during the first pregnancy(P=0.017).The rate of severe hypertension(P=0.005),polyhydramnios,meconium-stained amniotic fluid,nonreassuring fetal heart rate and total perinatal mortality(P0.001)were higher in the second delivery of the recurrent SGA *** a logistic regression model,preterm delivery and birthweight5 th percentile at the first delivery was found to be independent risk factors for recurrence of an SGA neonate in the subsequent birth(relative risks:1.530,confidence interval:1.249-1.875;relative risks:1.826,confidence interval:1.641-2.030,respectively).Conclusion::Women with recurrent SGA neonates ha