检索结果-南通市图书馆

Human exposure to a mixture of endocrine disruptors and serum levels of thyroid hormones:A cross-sectional study

Journal of Environmental Sciences 2023年第3期125卷 641-649页

作者： Bing Yue Shangyong Ning Hongjian Miao Congrong Fang Jingguang Li Lei Zhang Yan Bao Sai Fan Yunfeng Zhao Yongning Wu NHC Key Laboratory of Food Safety Risk Assessment Chinese Academy of Medical Science Research Unit(No.2019RU014)China National Center for Food Safety Risk AssessmentBeijing 100022China Hematology Department Beijing HospitalNational Center of GerontologyBeijing 100730China Beijing Center for Disease Prevention and Control Beijing Research Center for Preventive MedicineBeijing 100013China

Exposure to endocrine disruptors(EDCs) could disrupt thyroid hormone homeostasis. However, human epidemiological studies reported inconsistent observations, and scarce information on the effect of a mixture of chemicals. The aim of the present study was to examine the associations of multiple chemicals with thyroid hormones among adults from China. We measured serum levels of thyroid hormones and urinary levels of 11 EDCs, including six phthalate metabolites, bisphenol A(BPA), bisphenol F(BPF), bisphenol S(BPS), perchlorate, and thiocyanate among 177 healthy adults without occupational exposure. Associations of multiple urinary analytes with serum thyroid hormones were examined by performing general linear regression analysis and bayesian kernal machine regression analysis. These EDCs were detected in almost all samples. After adjusting for various covariates, we observed only BPF significantly associated with total thyroxin(TT4)(β=-0.27, 95% confidence interval(CI) [-0.41,-0.14]), total triiodothyronine(TT3)(β=-0.02 95% CI [-0.03,-0.01]), free T4(fT4)(β=-0.02, 95% CI [-0.03,-0.01]), and free T3(fT3)(β=-0.04, 95% CI [-0.07,-0.01]), and mono-(2-ethyl-5-oxohexyl) phthalate(MEOHP) and monoethyl phthalate(MEP) positively associated with TT4(β=0.24, 95% CI [0.01, 0.48]) and fT4(β=0.02, 95% CI [0.01, 0.04]), respectively. Moreover, we observed significant dose-response relationships between TT4 and the mixture of11 EDCs, and BPF was the main contributor to the mixture effect, suggesting the priority of potential effect of BPF on disrupting thyroid function under a real scenario of human exposure to multiple EDCs. Our findings supported the hypothesis that human exposure to low levels of EDCs could alter thyroid hormones homeostasis among non-occupational healthy adults.

关键词： Human urine Endocrine disruptors Joint effect thyroid hormones

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

thyroid hormones and thyroid hormone receptors: Effects of thyromimetics on reverse cholesterol transport

引用

World Journal of Gastroenterology 2010年第47期16卷 5958-5964页

作者： Matteo Pedrelli Camilla Pramfalk Paolo Parini Division of Clinical Chemistry Department of Laboratory Medicine Molecular Nutrition Unit Biosciences and Nutrition Karolinska Institutet at Karolinska University Hospital Huddinge

Reverse cholesterol transport (RCT) is a complex process which transfers cholesterol from peripheral cells to the liver for subsequent elimination from the body via feces. thyroid hormones (THs) affect growth, develop- ment, and metabolism in almost all tissues. THs exert their actions by binding to thyroid hormone receptors (TRs). There are two major subtypes of TRs, TRα and TRβ, and several isoforms (e.g. TRα1, TRα2, TRβ1, and TRβ2). Activation of TRα1 affects heart rate, whereas activation of TRβ1 has positive effects on lipid and lipoprotein metabolism. Consequently, particular interest has been focused on the development of thyromimetic compounds targeting TRβ1, not only because of their ability to lower plasma cholesterol but also due their ability to stimulate RCT, at least in pre-clinical models. In this review we focus on THs, TRs, and on the effects of TRβ1-modulating thyromimetics on RCT in various animal models and in humans.

关键词： Cardiovascular disease Cholesterol Lipoprotein metabolism Reverse cholesterol transport thyroid hormones thyroid hormone receptors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association between lifestyle factors and thyroid function in young euthyroid adults

引用

Food Science and Human Wellness 2024年第1期13卷 265-275页

作者： Elisa Merchan-Ramirez Guillermo Sanchez-Delgado Lucas Jurado-Fasoli Francisco M Acosta Manuel Munoz-Torres Jose M.Llamas-Elvira Jonatan R Ruiz Sport and Health University Research Institute(iMUDS) Faculty of Sports ScienceUniversity of GranadaGranada 18016Spain Pennington Biomedical Research Center Baton Rouge 70808USA Faculty of Medicine University of GranadaGranada 18071Spain Turku PET Centre University of TurkuTurku 20500Finland Turku PET Centre Turku University HospitalTurku 20520Finland Biosanitary Research Institute of Granada(Ibs.Granada) Granada 18012Spain CIBERFES Instituto de Salud CarlosⅢMadrid 28029Spain Endocrinology and Nutrition Service University Hospital San CecilioGranada 18016Spain Nuclear Medicine Service "Virgen de las Nieves"University HospitalGranada 18014Spain

Purpose:The present work examines the associations of dietary habits,sedentarism,physical activity(PA)levels and sleep habits,with thyroid function in young euthyroid adults.Methods:A total of 105 young euthyroid adults participated in this cross-sectional study.thyroid function was determined in fasting conditions(>6 h).Dietary habits were measured by a food frequency questionnaire and three non-consecutive 24 h recalls,and different dietary intake and patterns were then estimated.The time spent in sedentary,PA levels and sleep habits were objectively measured using a wrist-worn accelerometer.Results:Energy and carbohydrate intake were positively associated with thyroid stimulating hormone(TSH)(β=0.222;R^(2)=0.102;P=0.022 andβ=0.425;R^(2)=0.129;P=0.007,respectively)whereas fat intake was negatively associated with TSH(β=-0.428;R^(2)=0.137;P=0.004).Energy intake was also positively associated with free triiodothyronine(β=0.277;R^(2)=0.137;P=0.004).Further,adherence to the Mediterranean diet was negatively related to TSH and free thyroxine(FT4)(β=-0.221;R^(2)=0.113;P=0.020 andβ=-0.268;R^(2)=0.071;P=0.007,respectively).Vigorous-intensity and overall PA were negatively associated with FT4(β=-0.227;R^(2)=0.052;P=0.022 andβ=-0.204;R^(2)=0.042;P=0.041,respectively).In contrast,no associations were found between sleep parameters and thyroid function.Conclusions:Lifestyle factors such as dietary intake and PA levels seems to be related to thyroid function even in young euthyroid adults.

关键词： thyroid hormones Dietary intake Sleep Physical activity Euthyroid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stimulating effect of thyroid hormones in peripheral nerve regeneration:research history and future direction toward clinical therapy

引用

Neural Regeneration Research 2018年第4期13卷 599-608页

作者： I.Barakat-Walter R.Kraftsik Department of Fundamental Neurosciences Faculty of Biology and MedicineUniversity of Lausanne

Injury to peripheral nerves is often observed in the clinic and severe injuries may cause loss of motor and sensory functions.Despite extensive investigation,testing various surgical repair techniques and neurotrophic molecules,at present,a satisfactory method to ensuring successful recovery does not exist.For successful molecular therapy in nerve regeneration,it is essential to improve the intrinsic ability of neurons to survive and to increase the speed of axonal outgrowth.Also to induce Schwann cell phenotypical changes to prepare the local environment favorable for axonal regeneration and myelination.Therefore,any molecule that regulates gene expression of both neurons and Schwann cells could play a crucial role in peripheral nerve regeneration.Clinical and experimental studies have reported that thyroid hormones are essential for the normal development and function of the nervous system,so they could be candidates for nervous system regeneration.This review provides an overview of studies devoted to testing the effect of thyroid hormones on peripheral nerve regeneration.Also it emphasizes the importance of combining biodegradable tubes with local administration of triiodothyronine for future clinical therapy of human severe injured nerves.We highlight that the local and single administration of triiodothyronine within biodegradable nerve guide improves significantly the regeneration of severed peripheral nerves,and accelerates functional recovering.This technique provides a serious step towards future clinical application of triiodothyronine in human severe injured nerves.The possible regulatory mechanism by which triiodothyronine stimulates peripheral nerve regeneration is a rapid action on both axotomized neurons and Schwann cells.

关键词： peripheral nerve regeneration thyroid hormones thyroid hormone nuclear receptors biodegradable nerve growth guides axotomized neuron survival microsurgery reinnervation of denervated muscles compound muscle action potential

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analyses of levels of thyroid hormones and its receptor expression in puerperants and newborns from an e-waste dismantling site

引用

Frontiers of Medicine 2008年第3期2卷 276-282页

作者： Ying JU Guojian XU Lan CHEN Qi JIANG Liping LI Kedi YANG Xuemin CHEN Department of Occupational and Environmental Health and the MOE Key Lab of Environment and Health School of Public HealthHuazhong University of Science&TechnologyWuhan 430030China Research Center for Injury Prevention Shantou University Medical CollegeShantou 515031China

In this study,the serum levels,including thyr-oid hormones free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)among the sub-jects from the exposed group(n 548)and the control group(n 545)were detected by immuno radiometric assay(IRMA).The expression levels of TRa1,TRb1,TSHR mRNA in placentas and umbilical cords were detected by fluorescent quantitative real-time PCR(FQ-PCR).The correlations between the thyroid hormone levels in maternal serum and umbilical serum,and between the expression levels of its receptors mRNA in placentas and umbilical cords were determined.We found that the FT4 levels of both maternal serum and umbilical cord serum in the exposed group were lower than those in the control(Pthyroid hormones and in mRNA expression of its receptors.

关键词： electronic waste thyroid hormones hormone receptor puerperant infant newborn

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of LLLT systemic effects on thyroid hormones function after dental titanium implant installation:An experimental rabbit model

引用

Natural Science 2013年第8期5卷 933-940页

作者： Luciano Mayer Fernando Vacilotto Gomes Carlos Eduardo Baraldi Joao Batista Blessmann Weber Marília Gerhardt de Oliveira Department of Oral and Maxillofacial Surgery School of DentistryPontifícia Universidade Católica do Rio Grande do SulPorto AlegreBrazil Oral and Maxillofacial Surgery and Traumatology—Department of Surgery Universidade Federal do Rio Grande do SulSchool of DentistryRio Grande do SulBrazil Oral and Maxillofacial Surgery Service Hospital Cristo Redentor—Grupo Hospitalar ConceicaoPorto AlegreBrazil

This study aimed to assess the systemic effect of LLLT on thyroid gland functioning and consequently on calcium regulation through Triiodothyronine (T3) and Thyroxine (T4) measurements in rabbits’ serum. A total of thirty two New Zealand male rabbits were randomly distributed in four groups with eight animals each: control group C (nonirradiated animals), group EI (5 J/cm2 per session), group EII (10 J/cm2 per session) and group EIII (20 J/cm2 per session). All animals underwent lower left incisor extraction followed by immediate insertion of an osseintegrated implant, providing an equality of initial clinical condition between the groups. The experimental groups were irradiated with aluminium gallium arsenide diode laser (GaAlAs, λ = 830 nm, 50 mW, CW), during 13 days at each 48 hours, totalizing 7 sessions. Laboratorial T3 and T4 measurements were done in four distinct moments (before surgical procedure, immediately after surgical procedure, after the first LLLT session and after the last LLLT session) in all animals. The results obtained showed statistically significant differences in Triiodothyronine values between the groups throughout the experiment. It was concluded that the LLLT, in the protocol of irradiation used in this study, promoted a significantly alteration on rabbits’ serum hormonal levels.

关键词： thyroid Gland Laser Therapy Low Level thyroid hormones Dental Implant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Serum Level of thyroid hormones in Patients with Chronic Hepatitis C Virus Infection

引用

Open Journal of Endocrine and Metabolic Diseases 2016年第3期6卷 126-134页

作者： Mohamed Abdel-Fattah El-Feki Nilly Helmy Abdalla Mohamed Ibrahim Atta Ahmed Amin Ibrahim Internal Medicine Department Faculty of Medicine Beni Suef University Beni Suef Egypt

Objective: There are clinical and laboratory associations between thyroid and liver diseases. Hepatitis C virus (HCV) is known to be responsible for both hepatic and extrahepatic diseases. The most frequent and clinically important endocrine extrahepatic diseases are thyroid disorders and type 2 diabetes mellitus. We aim to study the relationship between the serum level of thyroid hormones (THs) and the severity of liver disease in patients with chronic hepatitis C virus (CHC) infection. Methods: 60 patients with CHC infection were selected for the study. They were divided into two groups: with or without liver cirrhosis. Those with liver cirrhosis were further subdivided according to the Child-Turcotte-Pugh scoring system. Serum levels of free T3 (FT3), free T4 (FT4) and TSH were measured to all patients. Results: There was decrease in the FT3 and FT4 levels and increase in the TSH levels in patients with CHC with cirrhosis when compared to patients with CHC without cirrhosis. Conclusion: thyroid profile abnormalities were seen in cirrhotic HCV patients when compared to non-cirrhotic patients. The abnormalities in the serum level of THs (decreased FT3, FT4, and increased TSH) are strongly associated with the severity of liver damage and advancing of the child score.

关键词： Hepatitis C Virus thyroid hormones Liver Cirrhosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The effects and mechanisms of thyroid hormones in the cardiovascular system

引用

South China Journal of Cardiology 2019年第4期20卷 269-279页

作者：张延春张金国 Jining Medical University Department of Cardiology the Affiliated Hospital of Jining Medical University

Background thyroid hormones(THs) including thyroxine(T4) and triiodothyronine(T3) with high biological activities have important effects on cardiovascular system by acting on renin-angiotensin-aldosterone system(RAAS), oxidative stress, mitochondria, endothelial cells, vascular smooth muscle cells(VSMC), cardiomyocytes, thyroid hormone receptor(TRs), cholesterol metabolism, insulin sensitivity, blood coagulation, etc. Excess or lack of THs is detrimental to cardiovascular function, so this article reviews the mechanism of THs on cardiovascular system.[S Chin J Cardiol 2019;20(4):269-279]

关键词： thyroid hormones renin-angiotensin-aldosterone system(RAAS) oxidative stress vascular smooth muscle cells(VSMC) cardiomyocytes thyroid hormone receptor(TRs) cholesterol metabolism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of thyroid hormones Levels in Female Ducks Blood and Embryo

引用

Animal Husbandry and Feed Science 2013年第2期5卷 53-55,59页

作者： SONG Wei-tao LI Hui-fang HU Yan ZHU Wen-qi XU Wen-juan Jiangsu Institute of Poultry Science Jiangsu Provincial Key Lab.for Genetics and Breeding of Poultry

[Objeclive] The comparison of levels of thyroid hormones （T3, T4 and FT3） in female ducks serum and embryo of different embryonic age between Gaoyou duck and Jinding duck were made to provide basic data for further research. [Method] The levels of thyroid hormones （T3, T4 and FT3） in female ducks serum, fertilized eggs, and 7, 11,15, 19, 22, 28-days embryo of Gaoyou duck and Jinding duck were analyzed with radioimmunoassay （RIA）. [ Result]The levels of thyroid hormones in fertilized eggs were higher than those in serum of female ducks; different em- bryonic age hormone level of Gaoyou duck and Jinding duck in serum had almost the same variation trend, which was low but relatively stable after 15 days. [Condusion] The result suggested that thyroid hormones play an important role in duck embryonic development, especially in the early peded.

关键词： Gaoyou duck Jinding duck Embryonic development thyroid hormones Radioimmunoassay （ RIA）

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The effect of mustard seed meal(Sinapis arvensis)on thyroid hormones and liver enzymes in Japanese quails(Coturnix coturnix japonica)

引用

Journal of Coastal Life Medicine 2016年第7期4卷 552-555页

作者： Sajjad Mohebali Mohammad Salarmoini Neda Eskandarzade Department of Animal Science Shahid Bahonar University of KermanKermanIran Department of Biochemistry School of Veterinary MedicineShahid Bahonar University of KermanKermanIran

Objective:To investigate the effect of wild black mustard seed meal on thyroid hormones(thyroxine and thyroid-stimulating hormone)in Japanese quails and also study the ability of FeSO4 to alleviate the possible negative effect of mustard meal on thyroid hormones in these birds for the first time.Methods:The experimental procedure was undertaken on 28 quails which were randomly assigned to a control and 6 test groups with 4 quails in each group for 28 days,during which the control group received basic diet with no mustard meal whereas the test groups(No.2,3 and 4)received mustard meal(5%,10%and 15%,respectively)and test groups(No.5,6 and 7)received FeSO_(4)(1%)-treated mustard meal(5%,10%and 15%,respectively)on the basic of basic diet.Results:The group fed on 15%non-treated mustard seed meal had the least thyroxine level and its level backed to normal in group fed on 15%FeSO4-treated mustard seed meal although this group had the highest alanine transaminase and aspartate transaminase levels.Conclusions:We concluded that up to 10%FeSO4 mustard seed meal could be incorporated in the quail diet successfully with the least damage to thyroids and livers,but further investigations on these birds are still needed to confirm this hypothesis.

关键词： Mustard seed meal thyroid hormones Liver enzymes Japanese quails T4

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：