Stimulating effect of thyroid hormones in peripheral nerve regeneration:research history and future direction toward clinical therapy

作     者：I.Barakat-Walter R.Kraftsik 

作者机构：Department of Fundamental NeurosciencesFaculty of Biology and MedicineUniversity of Lausanne 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第4期

页      面：599-608页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Swiss National Science Foundation SUVA foundation Novartis foundation 

主　　题：peripheral nerve regeneration thyroid hormones thyroid hormone nuclear receptors biodegradable nerve growth guides axotomized neuron survival microsurgery reinnervation of denervated muscles compound muscle action potential 

摘      要：Injury to peripheral nerves is often observed in the clinic and severe injuries may cause loss of motor and sensory *** extensive investigation,testing various surgical repair techniques and neurotrophic molecules,at present,a satisfactory method to ensuring successful recovery does not *** successful molecular therapy in nerve regeneration,it is essential to improve the intrinsic ability of neurons to survive and to increase the speed of axonal *** to induce Schwann cell phenotypical changes to prepare the local environment favorable for axonal regeneration and ***,any molecule that regulates gene expression of both neurons and Schwann cells could play a crucial role in peripheral nerve *** and experimental studies have reported that thyroid hormones are essential for the normal development and function of the nervous system,so they could be candidates for nervous system *** review provides an overview of studies devoted to testing the effect of thyroid hormones on peripheral nerve *** it emphasizes the importance of combining biodegradable tubes with local administration of triiodothyronine for future clinical therapy of human severe injured *** highlight that the local and single administration of triiodothyronine within biodegradable nerve guide improves significantly the regeneration of severed peripheral nerves,and accelerates functional *** technique provides a serious step towards future clinical application of triiodothyronine in human severe injured *** possible regulatory mechanism by which triiodothyronine stimulates peripheral nerve regeneration is a rapid action on both axotomized neurons and Schwann cells.