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A Novel Route to synthesize N,N-Dimethyl Arylmethylamines from Aryl Aldehydes, Hexamethylenetetramine and Hydrogen

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Chinese Journal of Chemistry 2020年第8期38卷 842-846页

作者： Zhengang Ke Bo Yu Yunyan Wu Yanfei Zhao Peng Yang Shien Guo Zhimin Liu Beijing National Laboratory for Molecular Sciences Key Laboratory of ColloidInterface and ThermodynamicsCAS Research/Education Centre for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Physical Science Laboratory Huairou National Comprehensive Science CenterBeijing 101407China

Developing simple and green routes to access valuable chemicals is of significance.Herein,we present a green and novel route to synthesize N,N-dimethyl arylmethylamines(DAMAs)from hexamethylenetetramine(HMTA)and aryl aldehydes in the presence of hydrogen,and a series of DAMAs can be obtained in good yields.This approach opens the precedent for HMTA as N,N-dimethylamine source to synthesize chemicals with N,N-dimethylamine group,which has promising applications for N-containing chemicals synthesis.

关键词： synthesis. amines synthesize

Synthesis,structure and properties of three novel transition-metal-containing tantalum-phosphate clusters

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Chinese Chemical Letters 2022年第10期33卷 4675-4678页

作者： Xue Li Hui Zhao Yuyan Li Yuanyuan Yang Mingyang Zhang Suyi Liu Pengtao Ma Jingping Wang Jingyang Niu Henan Key Laboratory of Polyxometalate Chemistry College of Chemistry and Chemical EngineeringHenan UniversityKaifeng 475004China

Peroxide ligation of aqueous metal-oxo clusters provides rich speciation and structural diversity.Here,three novel transition-metal derivatives of polyoxometalate anions,[Ni_(2)(H_(2)O)_(10){P_(4)Ta_(6)(O_(2))_(6)O_(24)}]^(6-)(1a),[Zn(H_(2)O)_(4){P_(4)Ta_(6)(O_(2))_(6)O_(24)}]^(8-)(2a)and[Cd(H_(2)O)_(4){P_(4)Ta_(6)(O_(2))_(6)O_(24)}]^(8-)(3a),have been successfully synthesized by adopting a one-pot reaction strategy.All of these hexatantalates are built from a new-type phosphorus-incorporated hexatantalates.We investigated the solution behaviors,and the peak assignments of the MS spectra indicated some degree of stability of them in water.Furthermore,the proton-conducting ability of compound 1a was also explored and it has shown well conductivity at high relative humidities,with conductivity achieved 1.22×10^(-3) S/cm(85℃,90%RH).

关键词： Polyoxotantalates Transition-metal synthesize Structure Proton-conduction

Detection,isolation,and characterization of a novel impurity from several folic acid products

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第7期23卷 597-606页

作者： Qirong SHEN Quan HE Yuanjiang PAN Cuirong SUN College of Pharmaceutical Sciences Zhejiang UniversityHangzhou310058China Department of Chemistry Zhejiang UniversityHangzhou310027China Hangzhou Qianyuan Pollen Pharmaceutical Co. Ltd.Hangzhou310018China

Folic acid belongs to the group of water-soluble B vitamins and naturally exists in multiple forms in a wide variety of foods such as legumes,vegetables,liver,and milk(Iyer and Tomar,2009;Lyon et al.,2020).It is involved in many biochemical reactions critical for cell division,such as purine and pyrimidine biosynthesis,DNA/RNA biosynthesis,and amino acid metabolism(Iyer and Tomar,2009).Mammals cannot synthesize folic acid and thus they must acquire it from food.Although folic acid is ubiquitous in foods.

关键词： belongs characterization synthesize

PI4P STimulatING innate immune activation:beyond the Golgi

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Cellular & Molecular Immunology 2023年第12期20卷 1399-1400页

作者： Yi Zheng Xuejing Zhang Chengjiang Gao Key Laboratory of Infection and Immunity of Shandong Province Department of ImmunologySchool of Basic Medical SciencesShandong UniversityJinan250012ShandongChina

The cGAS–STING pathway is pivotal for sensing cytosolic DNA[2].cGAS,a cytoplasmic DNA sensor,can be stimulated by DNA,and it consumes ATP and GTP to synthesize a second messenger,2'3'-cGAMP,which binds to STING,resulting in STING conformational change,oligomerization,and activation;ultimately,this process leads to the production of cytokines such as type I interferon to mediate antiviral and antitumor immune responses(Fig.1).Phosphoinositides,derived from phosphatidylinositol(PI),are phospholipids in membranes and are also crucial signaling molecules[3].The D-3,D-4,or D-5 positions in the inositol head group can be phosphorylated;therefore,a total of seven different PIP molecules exist in eukaryotes.Phosphatidylinositol 4-phosphate(PI4P)is distributed in various membrane components,with the highest amount in the trans-Golgi network(TGN)[4].The PI4P level in cells is regulated by its PI4K synthetases(PI4KA,PI4KB,PI4K2A,and PI4K2B)and the lipid phosphatase SAC1.In addition to being a precursor for PIP2 and PIP3,PI4P is a crucial signaling molecule involved in vesicular transport,lipid transport,and organelle morphology maintenance.

关键词： activation positions synthesize

A small,polyphyletic group of Firmicutes synthesizes trimethylamine from L-carnitine

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mLife 2023年第3期2卷 267-271页

作者： Marius Vital Ylenia Heinrich-Sanchez Hannover Medical School Institute for Medical Microbiology and Hospital EpidemiologyHannoverGermany

Impact statement Gut microbiota-derived trimethylamine(TMA)is associated with cardiometabolic disorders and exemplifies a microbial involvement in the etiology of emerging,noncommunicable diseases,the leading causes of death worldwide.Three bio-chemical pathways taking dietary compounds as intake have been described with distinct taxa involved that are all present at low relative abundances.A recently discovered pathway is now considered to be the main route for TMA synthesis from L-carnitine involvingγ-butyrobetaine as an intermediate product.By comprehensive(meta)genomic screening of publicly available data,namely,genomes of the UHGG catalog(n>200,000)and 10 metagenomic(transcriptomic)data sets,we revealed bacteria synthesizing TMA via this pathway and specified their ecophysiology.Results will contribute to stratification of individuals based on their gut microbiota's potential to synthesize TMA and might aid in the development of strategies restricting TMA formation.

关键词： product. synthesize statement

2-20 Attempt to synthesize a New Neutron-de cient Isotope 224Np

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IMP & HIRFL Annual Report 2014年第1期 56-56页

作者： Huang Tianheng Liu Zhong Ding Bing Sun Mingdao 不详

Nuclei in the light actinide region with Z 92，N 134 are predicted to be candidates for shape coexistence[1],some nuclei in this region are also predicted to have stable octupole deformation[2]. Actinide nuclei with N=134have been produced up to plutonium (228Pu), and the lightest plutonium isotope and neptunium isotope discoveredso far are 228Pu and 225Np respectively. A campaign has been started to investigate the nuclei in this region. Thereaction 20Ne + 209Bi was used to produce 224Np (N=131) in fusion-evaporation reaction as the first step.

关键词： Neutron-deficient Isotope synthesize

Nanogridarene:A Rising Nanomolecular Integration Platform of Organic Intelligence

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Chinese Journal of Chemistry 2020年第1期38卷 103-105页

作者： Xinmiao Xie Ying Wei Dongqing Lin Chunxiao Zhong Linghai Xie Wei Huang Centre for Molecular Systems and Organic Devices(CMSOD) Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for BiosensorsInstitute of Advanced Materials(IAM)Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjingJiangsu 210023China Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)127 West Youyi RoadXi'anShaanxi 710072China

In the background of organic electronics,nanogridarenes with the criteria of well-defined edge and extendable vertexes were discovered toward chemical intellibots in 2014.Herein,Friedel-Crafts Gridization(FCG)as the molecular installing technology(MIT)will be highlighted to synthesize various monogrids,multigrids and polygrids that would be potential cornerstone of covalent window,molecular integration and circuit as well as organic robots.

关键词： corners vertex synthesize

Effects of S-adenosylmethionine on production of secondary metabolites in Streptomyces diastatochromogenes 1628

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第9期22卷 767-773页

作者： Yefeng HU Juan WANG Jie XU Zheng MA Andreas BECHTHOLD Xiaoping YU Zhejiang Provincial Key Laboratory of Biometrology and Inspection&Quarantine College of Life SciencesChina Jiliang UniversityHangzhou 310018China Institute for Pharmaceutical Sciences Pharmaceutical Biology and BiotechnologyUniversity of Freiburg79104 FreiburgGermany

Streptomyces are famous for their ability to synthesize a large number of bioactive compounds as secondary metabolites containing antibiotics,enzyme inhibi-tors,and other small molecules with potential physiological activity(Niu et al.,2016;Song et al.,2019;Yin et al.,2019).Secondary metabolites are produced by a multi-step reaction of a primary metabolite as a precursor(Liu et al.,2013;Li et al.,2021).Therefore,it is of great research significance to increase the overall synthesis level of antibiotics by increasing the amount of synthesis of precursors.

关键词： synthesis synthesize ochro

Antibacterial screening of silver nanoparticles synthesized by marine micro algae

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Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 797-799页

作者： D Devina Merin S Prakash B Valentine Bhimba Department of Biotechnology Udaya School of EngineeringUdaya NagarVellamodiAmmandivillai post-629204Kanyakumari DistrictTamil NaduIndia Department of Biotechnology Sathyabama UniversityChennai-600 119TamilnaduIndia

Objective:To explore the biosynthesis of silver nanoparticles synthesized by marine microalgae. Methods:Marine microalgae was collected from Central Marine Fisheries Research Institute (CMFRI,tuticorin) and cultured in the lab.Silver nanoparticles synthesis were observed in normal and microwave irradiated microalgae and screened against human pathogens for the presence of antimicrobials.Results:The presence of silver nanoparticle was confirmed by UV-Visible spectroscopy at 420 nm by the presence of plasmon peak.Further confirmation was done by scanning electron microscope(SEM).Conclusions:These results not only provide a base for further research but are useful for drug development in the present and future.

关键词： Silver nanoparticle Marine microalgae Screening antimicrobials synthesize