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Journal of Geriatric Cardiology 2024年第2期21卷 242-245页

作者： Wei CHEN Kun HUANG Wei-Wei GUO Fan ZHOU De-Ning LIAO Department of Cardiology Shanghai Jingan District Zhabei Central HospitalShanghaiChina Department of Cardiology Shanghai Changzheng HospitalShanghaiChina Department of Hematology Shanghai Jingan District Zhabei Central HospitalShanghaiChina

Cardiac tumors are ***,cardiac metastases can occur in up to 10%of patients with *** cardiac neoplasms,metastases are much more common than primary cardiac tumors.[1]Metastatic cardiac neoplasms most frequently metast... 详细信息

关键词： neoplasms sustained cardiac

R-loopAtlas:An integrated R-loop resource from 254 plant species sustained by a deep-learningbased tool

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Molecular Plant 2023年第3期16卷 493-496页

作者： Kuan Li Zhenzhen Wu Jincong Zhou Wei Xu Ling Li Chao Liu Wei Li Chengjun Zhang Qianwen Sun Center for Plant Biology School of Life SciencesTsinghua UniversityBeijing 100084China Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of ScienceKunming 650201China Tsinghua-Peking Center for Life Sciences Beijing 100084China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510623China Haiyan Engineering&Technology Center Zhejiang Institute of Advanced TechnologyJiaxing 314022China

R-loops are chromatin structures consisting of anRNA:DNA hybrid and the other single-stranded DNA,which widely exist among genomes from bacteria to higher eukaryotes and participate in a variety of biological processes(Zhou et al.,2022).Currently,a variety of approaches to detect genome-wide R-loops have been developed,and ssDRIP-seq(single-strand DNA ligation-based library preparation from DNA:RNA hybrid immunoprecipitation,followed by sequencing)is one of the widely utilized methods(Xu et al.,2022).However,there are many limitations to genome-wide R-loop mapping based on high-throughput *** example,the activity of restriction enzymes for genomic DNA fragmentation.

关键词： sustained Atlas

Cavefish mount a rapid and sustained regenerative response following skeletal muscle injury

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Zoological Research 2023年第4期44卷 776-778页

作者： Luke Olsen Huzaifa Hassan Fanning Xia Sarah Keaton Nicolas Rohner Stowers Institute for Medical Research Kansas CityMO 64110USA Department of Molecular&Integrative Physiology University of Kansas Medical CenterKansas CityKS 66160USA Department of Biological Sciences DePaul UniversityChicagoIL 60614USA

Dear Editor,Physical injury and tissue damage are prevalent throughout the animal kingdom,with the ability to regenerate quickly and efficiently providing a selective *** most vertebrates,skeletal muscle possesses a remarkable ability to regenerate,making it a valuable model for investigating the cellular processes underpinning tissue *** damage,skeletal muscle mounts a complex regenerative cascade centered around dedicated muscle stem cells,i.e.,satellite *** satellite cells are,in turn,regulated by both resident and infiltrating innate immune cells of myeloid lineage,which play a crucial role in activating and guiding the transition of satellite cells towards maturation(Chen et al.,2020;Tidball,2017;Tidball&Villalta,2010).While critical for muscle regeneration,the innate immune system is energetically costly,resulting in many species decreasing immune investment under nutrient-limited *** this reduced investment results in a decreased capacity to mount a regenerative response following tissue damage remains ***,we utilized an emerging evolutionary model,the Mexican tetra(Astyanax mexicanus),to investigate the consequences of shifts in immune system investment on skeletal muscle regeneration.

关键词： sustained mount injury

Reciprocal activation of antigen-presenting cells and CAR T cells triggers a widespread endogenous anti-tumor immune response through sustained high-level IFNγproduction

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Cancer Biology & Medicine 2023年第11期20卷 779-782页

作者： Yelei Guo Chuan Tong Zhiqiang Wu Yuting Lu Yao Wang Weidong Han Department of Bio-therapeutic the First Medical CenterChinese PLA General HospitalBeijing 100853China

Adoptive cell transfer(ACT)using chimeric antigen receptor(CAR)modified T cells and T cell receptor(TCR)engineered T cells has shown therapeutic efficacy in cancer treatment1,*** T cells are widely applicable to tumor... 详细信息

关键词： sustained endogenous CAR

Good and bad outcomes of respiratory viral infections—influenza A virus trains sustained antitumor immunity of macrophages in the lung

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Cellular & Molecular Immunology 2023年第8期20卷 861-863页

作者： Sabine Stegemann-Koniszewski Sarah Frentzel Dunja Bruder Experimental Pneumology Department of PneumologyUniversity Hospital Magdeburg/Medical FacultyHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke University MagdeburgMagdeburgGermany Institute of Medical Microbiology and Hospital Hygiene Infection Immunology GroupHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke University MagdeburgMagdeburgGermany Immune Regulation Group Helmholtz Centre for Infection ResearchBraunschweigGermany

In their recent article in Nature Immunology, Wang et al. showed that influenza A virus (IAV) infection trained alveolar macrophages (AMs) for sustained antitumor immunity in the lung [1], extending the concept of trained immunity and pointing out benefits of viral respiratory infection in the context of pulmonary antitumor immune surveillance.

关键词： immunity sustained respiratory

sustained co-delivery of gemcitabine and cis-platinum via biodegradable thermo-sensitive hydrogel for synergistic combination therapy of pancreatic cancer

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Nano Research 2019年第6期12卷 1389-1399页

作者： Kun Shi Bingxin Xue Yanpeng Jia Liping Yuan Ruxia Han Fan Yang Jinrong Peng Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China

Pancreatic cancer is one of the most devastating cancers with poor prognosis and no significant change in the survival rate over the past *** targeted drug delivery through interventional endoscopic ultrasonography-guided fine-needle injection (EUS-FNI) is an attractive and minimally invasive strategy for inoperable pancreatic *** injectable in-situ formed long-lasting drug delivery system is a promising alternative for the localized treatment of pancreatic cancer via ***,a biodegradable thermo-sensitive copolymer hydrogel for the co-delivery of anticancer agents gemcitabine (GEM) and cis-platinum (DDP) was *** hydrogel is a free flowable liquid at room temperature that changes into a semi-solid hydrogel following injection in response to the physiological *** in vitro and in vivo drug release behaviors indicate sustained drug release of this delivery *** cellular proliferation inhibition and desirable apoptosis promotion have been found when pancreatic cancer Bxpc-3 cells were co-cultured with this GEM-DDP/hydrogel *** a single intratumoral injection,the dual-drug loaded hydrogel formulation exhibited superior anti-tumor efficacy and minimized systemic side effect on pancreatic cancer xenograft mouse model in comparison to the intravenously injected free GEM and DDP *** addition,a strong synergistic therapeutic effect of the GEM-DDP/hydrogel system against pancreatic cancer has been found in vitro and in vivo compared to the single-drug loaded hydrogel *** obtained findings suggest this developed thermo-sensitive copolymer hydrogel system as a potential universal carrier for the localized targeted delivery of multi-drugs,for use in a variety of inoperable solid tumors.

关键词： localized drug delivery sustained release thermo-sensitive hydrogel combination therapy pancreatic cancer

sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study

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World Journal of Gastroenterology 2019年第40期25卷 6094-6106页

作者： Gian Luca Colussi Debora Donnini Rosario Francesco Brizzi Silvia Maier Luca Valenti Cristiana Catena Alessandro Cavarape Leonardo Alberto Sechi Giorgio Soardo Department of Medicine University of Udine

BACKGROUND Direct-acting antiviral agents(DAAs)are extremely effective in eradicating hepatitis C virus(HCV)in chronically infected ***,the protective role of the sustained virologic response(SVR)achieved by second-and thirdgeneration DAAs against the onset of hepatocellular carcinoma(HCC)and mortality is less well *** To examine the occurrence of HCC or death from any cause in a retrospectiveprospective study of patients treated with *** Patients were enrolled from a tertiary academic hospital center for liver disease management that collects subject data mainly from northeastern *** study was conducted in 380 patients(age:60±13 years,224 males,32%with cirrhosis)treated with DAAs with or without SVR(95/5%),with a median follow up of 58 wk(interquartile range:38-117).The baseline anthropometric features,HCV viral load,severity of liver disease,presence of extra-hepatic complications,coinfection with HIV and/or HBV,alcohol consumption,previous interferon use,alphafetoprotein levels,and renal function were considered to be *** The incidence rate of HCC in patients with and without SVR was 1.3 and 59 per 100 person-years,respectively(incidence rate ratio:44,95%CI:15-136,P<0.001).Considering the combined endpoint of HCC or death from any cause,the hazard ratio(HR)for the SVR patients was 0.070(95%CI:0.025-0.194,P<0.001).Other independent predictors of HCC or death were low HCV viremia(HR:0.808,P=0.030),low platelet count(HR:0.910,P=0.041),and presence of mixed cryoglobulinemia(HR:3.460,P=0.044).Considering SVR in a multi-state model,the independent predictors of SVR achievement were absence of cirrhosis(HR:0.521,P<0.001)and high platelet count(HR:1.019,P=0.026).Mixed cryoglobulinemia predicted the combined endpoint in patients with and without SVR(HR:5.982,P=0.028 and HR:5.633,P=0.047,respectively).CONCLUSION DAA treatment is effective in inducing SVR and protecting against HCC or death.A residual risk of HCC persi

关键词： Direct-acting antiviral agents Hepatitis C virus Mixed cryoglobulinemia sustained virologic response Cirrhosis Survival analysis

Blue emitting CsPbBr3 perovskite quantum dot inks obtained from sustained release tablets

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Nano Research 2019年第12期12卷 3129-3134页

作者： Hewei Yang Yaqing Feng Zhiyu Tu Kuo Su Xiaozhi Fan Bingjie Liu Zhiping Shi Yuzhe Zhang Chenyang Zhao Bao Zhan School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China School of Life Sciences Tianjin UniversityTianjin 300072China

Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine(CsPbClxBr3-x,0 详细信息

Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine(CsPbClxBr3-x,0sustained release tablets with different shapes and *** to the limitation of the polymer networks onsolve nt releasi ng,the resulting CsPbBr3 qua ntum dots have the average size of 1.1±0.2 *** the basis of the excelle nt quantum confin eme nteffect and optimized surface passivation,the obtained PQD ink can emit high quality blue light for more than 6 *** work elucidates anew and convenient technique to prepare blue emission perovskite quantum dots ink with high stability and photoluminescence qua ntumyield and provides a great potential technology for the preparation of perovskite optoelectronic devices.

关键词： sustained release tablet perovskite quantum dot blue emitting perovskite ink polymer gel surface passivation

Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery

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Particuology 2018年第6期16卷 65-73页

作者： Emanuelle D.Freitas Jacyara M.M.Vidart Edson A.Silva Meuris G.C.da Silva Melissa G.A.Vieira Department of Processes and Products Design School of Chemical EngineeringUniversity of Campinas-UNICAMPAlbert Einstein Avenue50013083-852CampinasSPBrazil School of Chemical Engineering State University of West Parana-UNIOESTEFaculdade Street64585903-000ToledoPRBrazil

A sericin/alginate blend was successfully applied as a matrix for incorporation of *** provided a sustained release formulation,which could improve the therapeutic efficacy of ibuprofen and patient adherence to *** increased the proportion of drug incorporated into the particles (i.e., the drug incorporation efficiency),with incorporation rates between 73.01%±1.70%and 94.15%±4.21%. Alginate affected the drug release,and the particles with the maximum alginate mass fraction tested (2.8%)showed sustained release through a dissolution mechanism,reaching equilibrium after about *** of the incorporation efficiency and the drug release time showed the best results were for formulations with a high alginate *** electron microscopy,Fourier transform infrared spectroscopy,and X-ray diffraction analysis were used for particle characterization to study the incorporation of *** particle size range was 0.80±0.13to 1.08±*** size distributions of sericin-containing particles showed a good fit with the Gaussian model.

关键词： Sericin Alginate Ibuprofen sustained drug release

Ternary nanoparticle complex of ciprofloxacin exhibiting sustained release at gastric pH prepared by co-complexation with polyanions and an ionic amphiphile

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Particuology 2019年第4期17卷 58-65页

作者： Bingxue Dong Wean Sin Cheow Kunn Hadinoto School of Chemical and Biomedical Engineering Nanyang Technological University Singapore 637459 Singapore Singapore Institute of Technology Singapore 138683 Singapore

Poor bioavailability of the broad spectrum antibiotic ciprofloxacin (CIP) is caused by its narrow absorption window in the stomach. With the aim of prolonging the gastric reside nee time of CIP, we prepared a ternary nano particle complex (nan oplex) of CIP by co-complexation w ith polya nions (sodium dextran sulfate (DXT)) and an anionic amphiphile (sodium dodecyl sulfate (SDS)). We investigated the effect of the charge ratio of DXT to SDS on the size, zeta potential, CIP payload, and CIP utilization rate of the CIP-DXTSDS nanoplex and its dissolution characteristics in simulated gastrointestinal fluids. Fourier transform infrared spectroscopy, powder X-ray diffraction, and differential scanning calorimetry analyses showed that the ternary nanoplex was made up of amorphous C1P-DXT and crystalline CIP-SDS complexes. The size of the CIP-DXT-SDS nanoplex prepared at a >90% CIP utilization rate was 110-290 nm and it had a zeta potential of -16-39 mV, and CIP payload of 47-62%, depending on the charge ratio. At gastric pH, the CIP-DXT-SDS nanoplex prepared with a DXT:SDS charge ratio lower than 80:20 exhibited prolonged CIP release (60% dissolution after 8 h) compared with native CIP (100% dissolution after 1 h) and a binary CIP-DXT nanoplex (80% dissolution after 5 h), which was attributed to its lower solubility. The sustained release characteristics of the CIP-DXT-SDS nanoplex were comparable to those of existing CIP gastrorete ntive formulations.

关键词： Nanoparticle complex sustained drug release Solubility Amorphization Crystallization