Sustained co-delivery of gemcitabine and cis-platinum via biodegradable thermo-sensitive hydrogel for synergistic combination therapy of pancreatic cancer
经由为胰腺的癌症的 synergistic 联合治疗的可被细菌破坏的 thermo 敏感的 hydrogel 的 gemcitabine 和 cis 铂的持续合作交货作者机构：State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2019年第12卷第6期
页 面：1389-1399页
核心收录：
基 金：the National Natural Science Fund for Distinguished Young Scholars (No.31525009) the National Natural Science Foundation of China (Nos.31800797 and 31771096) the National Key Research and Development Program of China (No.2017YFC1103502) the China Postdoctoral Science Foundation funded project (No.2018M631094) the Postdoctoral Innovation Talents Support Program (No. BX20180207) 1-3-5 project for disciplines of excellence,West China Hospital,Sichuan University
主 题：localized drug delivery sustained release thermo-sensitive hydrogel combination therapy pancreatic cancer
摘 要：Pancreatic cancer is one of the most devastating cancers with poor prognosis and no significant change in the survival rate over the past *** targeted drug delivery through interventional endoscopic ultrasonography-guided fine-needle injection (EUS-FNI) is an attractive and minimally invasive strategy for inoperable pancreatic *** injectable in-situ formed long-lasting drug delivery system is a promising alternative for the localized treatment of pancreatic cancer via ***,a biodegradable thermo-sensitive copolymer hydrogel for the co-delivery of anticancer agents gemcitabine (GEM) and cis-platinum (DDP) was *** hydrogel is a free flowable liquid at room temperature that changes into a semi-solid hydrogel following injection in response to the physiological *** in vitro and in vivo drug release behaviors indicate sustained drug release of this delivery *** cellular proliferation inhibition and desirable apoptosis promotion have been found when pancreatic cancer Bxpc-3 cells were co-cultured with this GEM-DDP/hydrogel *** a single intratumoral injection,the dual-drug loaded hydrogel formulation exhibited superior anti-tumor efficacy and minimized systemic side effect on pancreatic cancer xenograft mouse model in comparison to the intravenously injected free GEM and DDP *** addition,a strong synergistic therapeutic effect of the GEM-DDP/hydrogel system against pancreatic cancer has been found in vitro and in vivo compared to the single-drug loaded hydrogel *** obtained findings suggest this developed thermo-sensitive copolymer hydrogel system as a potential universal carrier for the localized targeted delivery of multi-drugs,for use in a variety of inoperable solid tumors.
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