检索结果-南通市图书馆

Effect of hydrogen bonding and hydrophobic interaction on the formation of supramolecular hydrogels formed by L-phenylalanine derivative hydrogelator

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第8期18卷 1001-1004页

作者： Xin Jian Fu Shu Qin Cao Ning Xia Wang Sheng Zu Zhang Hong wang Ya Jiang Yang Department of Chemistry Huazhong University of Science and Technology Wuhan 430074 China

A new hydrogelator, pyridinium bromide salt of N-6-bromohexanoyl-L-phenylamino octadecane, was synthesized. supramolecular hydrogels can be formed through the self-assembly of this hydrogelator in water. In this work, D2O was used instead of H2O as solvent for FT-IR measurement due to the fact that it is impossible to obtain useful Fr-IR information on the hydrogen bonding in water. The investigation of PT-IR and steady-state fluorescence indicated that the driving forces for the self-assembly were mainly hydrogen bonding and hydrophobic interaction. Based on the data of XRD and molecular modeling, the possible mechanism of the formation of hydrogelator aggregates was proposed.

关键词： t-Phenylalanine derivatives Hydrogelator supramolecular hydrogels

Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第4期22卷 312-324页

作者： Yucong Li Linlong Li Ye Li Lu Feng Bin Wang Ming Wang Haixing Wang Meiling Zhu Yongkang Yang Erik IWaldorff Nianli Zhang Ingmar Viohl Sien Lin Liming Bian Wayne Yuk-Wai Lee Gang Li Department of Orthopaedics&Traumatology Stem Cells and Regenerative Medicine LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region Research&Clinical Affairs Orthofix Medical Inc.LewisvilleTXUSA Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong Special Administrative Region Innovation Centre for Advanced Interdisciplinary Medicine Key Laboratory of Biological Targeting DiagnosisTherapy and Rehabilitation of Guangdong Higher Education InstitutesThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhenPR China School of Biomedical Sciences and Engineering National Engineering Research Center for Tissue Restoration and ReconstructionKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationSouth China University of TechnologyGuangzhouPR China Department of Orthopaedics and Traumatology SH Ho Scoliosis Research LaboratoryJoint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing UniversityThe Chinese University of Hong KongHong Kong Special Administrative Region

Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged *** is widely used because it could provide rapid defect filling and proper structure support,and is biocompatible for cell aggregation and matrix *** have been made to seek suitable scaffolds for cartilage tissue *** Alg-DA/Ac-β-CD/gelatin hydrogel was designed with the features of physical and chemical multiple crosslinking and self-healing *** time,swelling ratio,biodegradability and biocompatibility of the hydrogels were systematically characterized,and the injectable self-healing adhesive hydrogel were demonstrated to exhibit ideal properties for cartilage ***,the new hydrogel design introduces a pre-gel state before photo-crosslinking,where increased viscosity and decreased fluidity allow the gel to remain in a semi-solid *** granted multiple administration routes to the hydrogels,which brings hydrogels the ability to adapt to complex clinical *** electromagnetic fields(PEMF)have been recognized as a promising solution to various health problems owing to their noninvasive properties and therapeutic *** treatment offers a better clinical outcome with fewer,if any,side effects,and wildly used in musculoskeletal tissue *** we propose PEMF as an effective biophysical stimulation to be 4th key element in cartilage tissue *** this study,the as-prepared Alg-DA/Ac-β-CD/gelatin hydrogels were utilized in the rat osteochondral defect model,and the potential application of PEMF in cartilage tissue engineering were *** treatment were proven to enhance the quality of engineered chondrogenic constructs in vitro,and facilitate chondrogenesis and cartilage repair in *** of the results suggested that with the injectable self-healing adhesive hydrogel and PEMF treatment,this newly proposed tissue engineering strategy r

关键词： supramolecular hydrogels Pulsed electromagnetic field Cartilage tissue engineering Mesenchymal stem cells Chondrogenesis

A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第9期7卷 103-119页

作者： Biao Yang Chengzhen Liang Di Chen Feng Cheng Yuang Zhang Shaoke Wang Jiawei Shu Xianpeng Huang Jingkai Wang Kaishun Xia Liwei Ying Kesi Shi Chenggui Wang Xuhua Wang Fangcai Li Qian Zhao Qixin Chen Department of Orthopedics Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009ZhejiangChina Orthopedics Research Institute of Zhejiang University Hangzhou310009ZhejiangChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou310009ZhejiangChina Ningbo Research Institute of Zhejiang University Ningbo315100ZhejiangChina State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027ZhejiangChina NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhou310003ZhejiangChina

The current effective method for treatment of spinal cord injury(SCI)is to reconstruct the biological microenvironment by filling the injured cavity area and increasing neuronal differentiation of neural stem cells(NSCs)to repair ***,the method is characterized by several challenges including irregular wounds,and mechanical and electrical mismatch of the material-tissue *** the current study,a unique and facile agarose/gelatin/polypyrrole(Aga/Gel/PPy,AGP3)hydrogel with similar conductivity and modulus as the spinal cord was developed by altering the concentration of Aga and *** gelation occurred through non-covalent interactions,and the physically crosslinked features made the AGP3 hydrogels *** vitro cultures showed that AGP3 hydrogel exhibited excellent biocompatibility,and promoted differentiation of NSCs toward neurons whereas it inhibited over-proliferation of *** in vivo implanted AGP3 hydrogel completely covered the tissue defects and reduced injured cavity *** vivo studies further showed that the AGP3 hydrogel provided a biocompatible microenvironment for promoting endogenous neurogenesis rather than glial fibrosis formation,resulting in significant functional *** sequencing analysis further indicated that AGP3 hydrogel significantly modulated expression of neurogenesis-related genes through intracellular Ca2+signaling ***,this supramolecular strategy produces AGP3 hydrogel that can be used as favorable biomaterials for SCI repair by filling the cavity and imitating the physiological properties of the spinal cord.

关键词： Conducting polymer supramolecular hydrogels Biomimetic scaffolds Nerve regeneration Spinal cord injury

Reinforcing DNA supramolecular Hydrogel with Polymeric Multiple-Unit Linker

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2023年第2期5卷 434-444页

作者： Yujie Li Yuqiao Ding Bo Yang Tianyang Cao Jiangfei Xu Yuanchen Dong Quan Chen Lijin Xu Dongsheng Liu Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 Department of Chemistry Renmin University of ChinaBeijing 100872 Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084 CAS Key Laboratory of Colloid Interface and Chemical ThermodynamicsBeijing National Laboratory for Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022

While supramolecular hydrogels have received growing interest due to their unique dynamic features,their relatively weak mechanical properties have largely limited their biomedical *** this study,we propose and demonstrate a strategy to reinforce the mechanical properties of supramolecular hydrogel by introducing polymeric multiple-unit linker(PMUL),which incorporates multiple supramolecular units into a polymeric backbone to crosslink supramolecular *** demonstrated that PMUL can effectively improve the kinetic stability of supramolecular crosslinkers through multiple-unit interaction in a DNA supramolecular hydrogel model system,thus leading to higher mechanical ***,the dynamic features of the supramolecular hydrogels have been well preserved,including shear-thinning,self-healing properties,and reversible thermal *** strategy offers a simple but effective way for mechanical reinforcement of supramolecular hydrogels to construct novel biomaterials.

关键词： mechanical reinforcement supramolecular hydrogels DNA polymericmultiple-unit linkers thermorheological behavior

Chirality Transfer in supramolecular Co-assembled Fibrous Material Enabling the Visual Recognition of Sucrose

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced Fiber Materials 2020年第4期2卷 204-211页

作者： Nabila Mehwish Xiaoqiu Dou Changli Zhao Chuanliang Feng Qiang Fu State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiaotong UniversityDongchuan Rd 800Shanghai 200240China State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Molecular recognition of simple sugars is crucial due to their essential roles in most living ***,it remains extremely challenging to achieve a visual recognition of simple sugars like sucrose in water media under physiological *** this article,the visual recognition of sucrose is accomplished by a chiral supramolecular hydrogel formation through the co-assembly of a two-component fibrous solution(l-phenylalanine based gelator co-diaminopyridine,LDAP)and sucrose.H-bonding between the amino group of LDAP and the hydroxyl group of sucrose facilitates the gelation by loading sucrose into the LDAP *** formed hydrogel showed an amplified inversion of circular dichroism(CD)signals as compared to the corresponding LDAP *** addition,the effective chirality transfer was accompanied by a bathochromic shift in UV-Vis and FL spectra of the *** a simple and straightforward chiral co-assembled strategy to visually recognize sucrose will have the potential use of smart gelators in saccharides separation and proteomics to be further applied in medical diagnostics and cell imaging.

关键词： supramolecular hydrogels Chirality inversion Molecular recognition Sugars Sucrose Glucose

[2+2]Photocycloaddition Reaction Regulated the Stability and Morphology of hydrogels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced Fiber Materials 2019年第3期1卷 241-247页

作者： Ting Peng Auphedeous Yinme Dang-i Jinying Liu Chuanliang Feng State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and EngineeringHenan UniversityKaifeng 475004China

Photoresponsive supramolecular gels as intelligent non-invasive responsive materials can undergo changes in color,state,morphology and electronic properties upon photo irradiation,making them attractive for a variety of ***,a novel supramolecular hydrogelator DBE with 1,4-divinylbenzene as the central core,connected via amide linkage to l-phenylalanine and peripheral hydrophilic groups,was designed to evaluate the effect of[2+2]photocycloaddition reaction on supramolecular *** irradiation decreases the solubility of the hydrogelator DBE and hence,causes the destruction of the *** images clearly show that irradiation with UV light could induce disintegration of the right-handed helical nanofibers entangled network,which turns into nanoparticles and eventually massive *** dichroism and vibrational circular dichroism data also indicate the formation of right-handed helical nanofibers in DBE *** and MALDI-TOF-MS spectrum confirm that the variation of stability and aggregated morphology of DBE gel after UV irradiation is attributed to[2+2]cycloaddition reaction of vinyl *** study presents a wonderful model for regulating the stability and aggregated morphology of supramolecular hydrogels via photo irradiation,as well as offers new ideas for designing novel photo responsive materials.

关键词： [2+2]Photocycloaddition reaction supramolecular hydrogels supramolecular chirality Vinyl units UV light