Reinforcing DNA Supramolecular Hydrogel with Polymeric Multiple-Unit Linker

作     者：Yujie Li Yuqiao Ding Bo Yang Tianyang Cao Jiangfei Xu Yuanchen Dong Quan Chen Lijin Xu Dongsheng Liu Yujie Li;Yuqiao Ding;Bo Yang;Tianyang Cao;Jiangfei Xu;Yuanchen Dong;Quan Chen;Lijin Xu;Dongsheng Liu

作者机构：Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyDepartment of ChemistryTsinghua UniversityBeijing 100084 Department of ChemistryRenmin University of ChinaBeijing 100872 Key Laboratory of Organic Optoelectronics and Molecular EngineeringDepartment of ChemistryTsinghua UniversityBeijing 100084 CAS Key Laboratory of ColloidInterface and Chemical ThermodynamicsBeijing National Laboratory for Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190 State Key Laboratory of Polymer Physics and ChemistryChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2023年第5卷第2期

页      面：434-444页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(grant nos.21890731,21821001,21534007,21971248,and 21890730) the National Basic Research Plan of China(grant no.2018YFA0208900) the Institute of Chemistry CAS(grant no.C220200701) 

主　　题：mechanical reinforcement supramolecular hydrogels DNA polymericmultiple-unit linkers thermorheological behavior 

摘      要：While supramolecular hydrogels have received growing interest due to their unique dynamic features,their relatively weak mechanical properties have largely limited their biomedical *** this study,we propose and demonstrate a strategy to reinforce the mechanical properties of supramolecular hydrogel by introducing polymeric multiple-unit linker(PMUL),which incorporates multiple supramolecular units into a polymeric backbone to crosslink supramolecular *** demonstrated that PMUL can effectively improve the kinetic stability of supramolecular crosslinkers through multiple-unit interaction in a DNA supramolecular hydrogel model system,thus leading to higher mechanical ***,the dynamic features of the supramolecular hydrogels have been well preserved,including shear-thinning,self-healing properties,and reversible thermal *** strategy offers a simple but effective way for mechanical reinforcement of supramolecular hydrogels to construct novel biomaterials.