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No Additional Cholesterol-Lowering Effect Observed in the Combined Treatment of Red Yeast Rice and Lactobacillus Casei in Hyperlipidemic Patients：A Double-Blind Randomized Controlled Clinical trial

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Chinese Journal of Integrative Medicine 2017年第8期23卷 581-588页

作者： Chien-Ying Lee Min-Chien Yu Wu-Tsun Perng Chun-Che Lin Ming-Yung Lee Ya-Lan Chang Ya-Yun Lai Yi-Ching Lee Yu-Hsiang Kuan James Cheng-Chung Wei Hung-Che Shih Institute of Medicine Chung Shan Medical University Taichung Taiwan 40201 China Department of Pharmacy Chung Shah Medical University Hospital Taichung Taiwan 40201 China Department of Pharmacology Chung Shan Medical University Taichung Taiwan 40201 China Department of Integrated Chinese and Western Medicine Chung Shan Medical University Hospital Taichung Taiwan 40201 China Department of Recreation Sport & Health Promotion National Pingtung University of Science and Technology Taiwan 91201 China Division of Hepatogastroenterology Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 40201 China Department of Statistics and Informatics Science Providence University Taiwan 43301 China Department of Applied Cosmetology National Tainan Junior College of Nursing China Taiwan 700 Department of Internal Medicine Chung Shan Medical University HospitalGraduate Institute of Integrated Medicine China Medical University Taichung Taiwan 40201 China

Objective：To observe the effect of combining red yeast rice and Lactobacillus casei（***）in lowering cholesterol in patients with primary hyperlipidemia,the later has also been shown to remove cholesterol in in vitro ***：A double-blind clinical trial was conducted to evaluate the cholesterol-lowering effect of the combination of red yeast rice and *** patients with primary hyperlipidemia were recruited and randomized equal y to either the treatment group（red yeast rice＋***）or the control group（red yeast rice＋placebo）.One red yeast rice capsule and two *** capsules were taken twice a *** treatment lasted for 8 weeks,with an extended follow-up period of 4 *** primary endpoint was a difference of serum low-density lipoprotein cholesterol（LDL-C）level at week ***：At week 8,the LDL-C serum level in both groups was lower than that at baseline,with a decrease of 33.85±26.66 mg/dL in the treatment group and 38.11±30.90 mg/dL in the control group;however,there was no statistical difference between the two groups（P〉0.05）.The total cholesterol was also lower than the baseline in both groups,yet without a statistical difference between the two *** only statistical y significant difference between the two groups was the average diastolic pressure at week 12,which dropped by 2.67 mm Hg in the treatment group and increased by 4.43 mm Hg in the placebo group（P〈0.05）.The antihypertensive activity may be associated with *** yeast rice can significantly reduce LDL-C,total cholesterol and ***：The combination of red yeast rice and *** did not have an additional effect on lipid profiles.

关键词： red yeast rice Lactobacillus casei,low-density lipoprotein cholesterol randomizedcontrolled trial

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Acupuncture therapy for angina pectoris:a systematic review

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Journal of Traditional Chinese Medicine 2012年第4期32卷 494-501页

作者： Ji Chen Yulan Ren Yong Tang Zhengjie Li Fanrong Liang Chengdu University of Traditional Chinese Medicine

OBJECTIVE： To assess the effectiveness and safety of acupuncture therapy for angina pectoris. METHODS： Randomized controlled trials （RCTs） concerned with acupuncture treatment of angina pectoris were identified by searching Academic Source Premier, MEDLINE, Science Citation Index Expanded, and three Chinese databases （China biol- ogy medicine database, China national knowledge infrastructure, and VlP database for Chinese techni- cal periodicals）. The valid data were extracted in ac- cordance with our inclusion and exclusion criteria. The main outcomes of the included studies were synthesized using Revman 5.1. RESULTS： Twenty-one articles on 16 individual studies were included and evaluated as having high or moderate risk of bias according to the stan- dards of the Cochrane Collaboration. Meta-analysis indicated that acupuncture combined with conven- tional drugs （ACCD） was superior to conventional drugs alone in reducing the incidence of acute myocardial infarction （AMI） [0R=0.18, 95%CI （0.04,0.84）, P=0.03]. Moreover, ACCD was superior to con- ventional drugs in the relief of angina symptoms [0R=4.23, 95%C/（2.73, 6..56）, P〈0.00001], and im- provement of electrocardiography （ECG） [0R=2.61, 95%C/（1.83, 3.73）, P〈0.00001]. Acupuncture by it- self was also superior to conventional drugs for angi- na symptoms [0R=3.59, 95%C/（1.76, 7.92）, P=0.0004] and ECG improvement [0R=3.07, 95%C/（1.54, 6.10）, P=0.001]. ACCD was superior to conventional drugs in shortening the time to onset of angina relief [WMD=-1.40, 95% CI （-1.65, -1.15）, P〈 0.00001]. However, the time to onset was signifi- cantly longer for acupuncture treatment than for conventional treatment alone [WMD=2A3, 95%O （1.63, 3.23）, P〈0.000 01]. CONCLUSION： ACCD reduced the occurrence of AMI, and both acupuncture and ACCD relieved an- gina symptoms and improved ECG. However, com- pared with conventional treatment, acupuncture showed a longer delay before its onset of action. This indicates that acupuncture is not suitabl

关键词： Acupuncture therapy randomizedcontrolled trial Efficacy Review Meta-analysis

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The Clinical Randomized Controlled trial on the Safety and Efficacy of Polyethersulfone Membrane Dialyzer in the Maintenance of Hemodialysis Patients

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Chinese Journal of Biomedical Engineering(English Edition) 2010年第4期19卷 148-155页

作者： GU Ying-li LIN Fu-jun ZHU Chun JIANG Geng-ru Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China

Objective： To observe the safety and efficacy of polyethersulfone membrane dialyzer used by chronic renal failure patients in clinical maintenance hemodialysis （MHD）. Methods： From January to February 2009, 36 patients were recruited from Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. The experiment was approved by the ethnical committee of Xinhua Hospital and under permissions fronl patients. All the patients were randomized into polyethersulfone group （PES, n=18） and polysulfone group （PS, n=18）. Hemodialysis was given by using Fresenius 4008S capacity-controlled dialyser and ultra-purified bicarbonate dialysate, more than 3.5 h each time, three times per-week, followed by heparin anticoagulation for a week, three times totally. Changes in blood urea nitrogen （BUN）, serum creatinine （Set）, phosphate （p2＋）, hemoglobin and albumin levels were determined for the efficacy and safety evahlation. Results： The serum BUN, Set and p2＋ concentrations significantly reduced after hemodialysis with different dialyzers, and the decrease amplitude of two groups was equivalent（P〉0.05）. The clearance rate of the serum BUN and Scr had no significant difference among two groups（P〉O.05）. The clearance rate （ml/min） of the sermn P^2＋ was 144.57 ±27.83 v.s. 117.15 ±22.77 in two groups. The clearance rate of the serum p^2＋ in PES group was more than that in PS group, and the difference was significant between two groups （P=0.0001）. It was indicated that PES and PS membrane could efficiently eliminate serum mieromolecule solute in MHD patients, so PES membrane excelled PS membrane in eliminating serum p2＋. The hemodialysis safety index, for example serum hemoglobin, albumin and blood pressure, had no significant difference between the two groups before and after hemodialysis （P〉0.05）. Conclusion： The efficacy and safety of the PES hollow fiber membrane dialyzer is equivalent to that of the imported PS membrane dialyzer in hemodialysis for MHD pat

关键词： hemodialysis polyethersulfone membrane dialyzer randomizedcontrolled trial solute blood phosphate

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Electroacupuncture in Treating Depression:A Randomized Controlled Study

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Journal of Acupuncture and Tuina Science 2013年第1期11卷 42-45页

作者： Chen Xiu-ling Xu Kai Luo Ren-han Lin Miao-jun Hong Jue Fangcun Hospital of Traditional Chinese Medicine the Third Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine Guangdong Second Provincial Traditional Chinese Medicine Hospital

Objective: To observe the clinical efficacy of electroacupuncture in treating depression. Methods: By a randomized controlled study method, sixty patients with depression were randomized into an electroacupuncture group and a medication group, 30 in each. The electroacupuncture group was treated with electroacupuncture, and the medication group was orally administrated Paroxetine tablets. They were evaluated by using Hamilton Depression Scale (HAMD) before and after treatments and the safety was also assessed. Results: The total effective rate was 83.3% in the electroacupuncture group versus 60.0% in the medication group, and the difference was statistically significant (P<0.05). The electroacupuncture group was superior to the medication group in comparing the improvement of HAMD scores after treatment (P<0.05). Conclusion: Electroacupuncture is an effective approach in treating depression.

关键词： Acupuncture Therapy Electroacupuncture Depression randomizedcontrolled trial

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Observation on clinical efficacy of acupuncture combined with direct moxibustion with fine-strip moxa for 62 cases of herpes zoster

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World Journal of Acupuncture-Moxibustion 2014年第2期24卷 15-18,24页

作者：李梦苟春雁王毅刚重庆市中医院针灸科

Objective To evaluate the clinical effect of acupuncture combined with direct moxibustion with fine-strip moxa for herpes zoster. Methods Sixty-two patients with herpes zoster were randomly divided into two groups according to attendance number, 32 in acupuncture group and 30 in western medicine group. The patients in the acupuncture group were treated by acupuncture at the nidus-related nerve segments Jiaji （夹脊 EX-B2） in combination with direct moxibustion with fine-strip moxa, while the patients in the western medicine group were treated by oral valaciclovir hydrochloride, vitamin B1, vitamin B12. The times of response, incrustation and decrustation were observed respectively, and pain relief degree of the two groups were compared. Results The response time, incrustation time and decrustation time of the acupuncture group were all less than those of the western medicine group [（1.74±0.43） days vs （3.86±0.58） days, （2.03±0.52） days vs （5.46±0.65） days, （5.14±0.33） days vs （8.34±0.59） days, all P〈O.05]. The pain relief degree （VAS score）, and pain duration in the acupuncture group were all higher obviously than those of the western medicine group [（10.41±12.1） vs （15.63±11.39）, （4.78±0.45） days vs （8.12±0.63） days, all P〈O.05]. The total effective rate of the acupuncture group was 96.9% （31/32）and that of the western medicine group was 90% （27/30）, thus the therapeutic effect of acupuncture group was better than that of western medicine group （P〈0.05）. Conclusion The therapeutic effect of acupuncture combined with direct moxibustion with fine-strip moxa is remarkable. It can effectively control the development of herpes zoster, alleviate pain and shorten therapy periods. It is worthy to be promoted and applied.

关键词： herpes zoster acupuncture therapy fine-strip moxa randomizedcontrolled trial

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