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Asian Pacific Journal of Tropical Medicine 2014年第1期7卷 9-15页

作者： Vivek K.Bajpai Ajay Sharma Sun Chul Kang Kwang-Hyun Baek School of Biotechnology Yeungnam UniversityGyeongsanGyeongbook 712-749Republic of Korea

Objective:To investigate the antioxidant enicacy of a biologically active dilerpenoid compound sugiol isolated from Metasequoia glyptostroboides(***)in various antioxidant ***:An abietane type diterpenoid sugiol,isolated from ethyl acetate extract of *** cones,was analyzed for its antioxidant efficacy as reducing power ability and lipid peroxidation inhibition as well as its ability to scavenge free radicals such as 1,1-diphenyl-2-picryl hydrazyl,nitric oxide,superoxide and hydroxyl ***:The sugiol showed significant and concentration-dependent antioxidant and free radical scavenging ***,the sugiol exerted lipid peroxidation inhibitory effect by 76.3%as compared to a-tocopherol(80.13%)and butylaled hydroxyanisole(76.59%).In addition,the sugiol had significant scavenging activities of l,l-diphenyl-2-picryl hydrazyl,nitric oxide,superoxide and hydroxyl free radicals in a concentration-dependent manner by 78.83%,72.42%,72.99%and 85.04%,when compared to the standard compound ascorbic acid(81.69%,74.62%,73.00%and 73.79%)and a-tocopherol/butylated hydroxyanisole(84.09%,78.61%,74.45%and 70.02%),***:These findings justify the biological and traditional uses of *** or its secondary metabolites as confirmed by its promising antioxidant efficacy.

关键词： Sugiol Diterpenoid Antioxidant Free radicals Lipid peroxidation

Phototoxic effect of UVR on wild type, ebony and yellow mutants of Drosophila melanogaster: Life Span, fertility, courtship and biochemical aspects

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Science China(Life Sciences) 2008年第10期51卷 885-893页

作者： WANG ZhePeng1,2, LIU RuiFang2, WANG AnRu3, DU LiLi1 & DENG XueMei1 1 College of Animal Science and Technology, China Agricultural University, Beijing 100094, China 2 Vocational and Technologic College, Inner Mongolia Agriculture University, Baotou 014109, China 3 College of Veterinary Medicine, China Agricultural University, Beijing 100094, China College of Animal Science and Technology China Agricultural University Beijing China Vocational and Technologic College Inner Mongolia Agriculture University Baotou China College of Veterinary Medicine China Agricultural University Beijing China

Melanin plays an important role in protecting organisms from ultraviolet radiation (UVR). Therefore, it is possible that differently colored strains can show different sensitivities to UVR. In the present work, life span, fertility and courtship behavior of wild type (w), ebony (e) and yellow (y) strains of Drosophila melanogaster were studied to evaluate their sensitivity to ultraviolet (UV). Because a range of photo- toxic effects of UVR are mediated through generation of free radicals, levels of free radicals, lipid per- oxide (malondialdehyde, MDA) and superoxide dismutase (SOD) activity of three strains were examined to indicate their antioxidant defending ability and oxidative status. It was shown that w always had the highest lifespan and fertility not only in the control but also in UV-exposed groups. Moreover, lifespan and fertility of e were significantly higher (P0.05). MDA levels were increased in the UV dose-dependent manner (P=0.0495). In con- clusion, our results suggested that UVR can decrease life span and fertility of flies and do harm to courtship, which may be due to oxidative damage to flies tissues (e.g. central nervous system) induced by free radicals. w had the highest tolerance to UVR, which may be ascribed to its advantage of survival under the natural condition and at high level of SOD activity. Then differences of pigment between e and y in absorbing UV, shielding agai

关键词： ultraviolet radiation Drosophila melanogaste free radicals pigment

Hepatoprotective and antioxidant capacity of Melochia corchorifolia extracts

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Asian Pacific Journal of Tropical Medicine 2013年第7期6卷 537-543页

作者： B Ganga Rao Y Venkateswara Rao T Mallikarjuna Rao A.U College of Pharmaceutical Sciences Andhra UniversityVisakhapatnamAndhra PradeshIndia-530003 Department of Botany College of Science and TechnologyAndhra University.VisakhapatnamAndhra PradeshIndia-530003

Objective:To evaluate bepato protective and antioxidant capacity of Melochia corchorifolia （***）aerial part ***:Antioxidant activitywas evaluated by using three free radicals（Superoxide,Hydroxyl and DPPH） and hepatoprotective activity was assessed against CCl4 induced liver intoxication in ***:The extracts produced concentration dependent percentage protection in decrease of serum enzymes and percentage inhibition on free *** all extracts methanol extract showed better activity with percentage protection of SGOT（78.98%）,SGPT（79.65%）,ALP（82.48%） and total bilirubin（80.0%）levels against CCl4 liver intoxication and also methanolic extract showed better activity with IC50 values on superoxide. hydroxyl and DPPH radicals were 127μg.240μg and 179μ***:From the results obtained during the study it could be concluded that *** aerial part extracts have antioxidant and hepaloprotective *** study is necessary for isolation and characterization of bioactive molecules which are responsible for hepatoprotective and antioxidant activity.

关键词： Melochia corchorifolia Aerial parts Free radicals Antioxidant Activity CCl4 Hepatoprotective activity

Training session intensity affects plasma redox status in amateur rhythmic gymnasts

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Journal of Sport and Health Science 2019年第6期8卷 561-566页

作者： Marianna Bellafiore Antonino Bianco Giuseppe Battaglia Maria Silvia Naccari Giovanni Caramazza Johnny Padulo Karim Chamari Antonio Paoli Antonio Palma Sport and Exercise Sciences Research Unit University of PalermoPalermo 90144Italy University"eCampus" Novedrate 22060Italy Faculty of Kinesiology University of SplitSplit 21000Croatia Athlete Health and Performance Research Centre ASPETARQatar Orthopaedic and Sports Medicine HospitalDoha 29222Qatar Department of Biomedical Sciences(DSB) University of PadovaPadova 35131Italy

Purpose:The aim of this study was to examine systemic responses of oxidant/antioxidant status following 2 training sessions of different intensity in amateur rhythmic ***:Before the experimental training,10 female gymnasts performed a gradually increased exercise test to assess maximal heart rate,maximal oxygen consumption,and anaerobic *** executed 2 intermittent training sessions separated by 48 h of recovery(48 h-post R):the first was performed at low-moderate intensity(LMI)and the second at high intensity(HI).Blood samples were collected immediately preand post-training and 48 h-post *** level(OxL)and total antioxidant capacity(TAC)were photometrically ***:OxL was significantly higher in post-training and 48 h-post R following HI than the same conditions after an LMI session(HI *** post-training:381.10±46.17(mean±SD)vs.344.18±27.94 Units Carratelli(***);48 h-post R:412.21±26.61 vs.373.80±36.08 ***).There was no change in TAC between the 2 training sessions *** LMI training,OxL significantly decreased in post-training and increased to reach the baseline at 48 h-post R,whereas TAC increased only at 48 h-post *** HI training,OxL significantly increased to reach a high oxidative stress 48 h-post R,whereas TAC was lower in post-training than ***:The pattern of OxL and TAC levels implies different regulation mechanisms by HI and LMI training *** oxidative stress induced by an HI protocol might be associated with both insufficient TAC and recovery time at 48 h necessary to restore redox balance.

关键词： Antioxidant capacity Exercise physiology Free radicals Oxidative stress Reactive oxygen species Rhythmic gymnastics Training intensity

Evidence for oxidative damage to prion protein in prion diseases

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Chinese Science Bulletin 2000年第17期45卷 1546-1554页

作者： YANG Chiming (Chi Ming Yang)Institute for Life Science and Health at UCSD, P. O. Box 12035, La Jolla, CA 92039, USA: College of Life Science & Biotechnology, Shanghai JiaoTong University. Shanghai 200030, China: College of Chemistry, Nankui University, Tianjin 300071, Institute for Life Science and Health at UCSD La Jolla USA Shanghai JiaoTong University College of Life Science & Biotechnology China Nankai University College of Chemistry China

In prion diseases the irreversible protein structural transformation process is completed in the brains of mammals within a few months, the uniformly generated infectivity displays extraordinary resistance to inactivation, suggesting that a vital energy source is required for the production of infectious particles. Considering the high oxygen-respiration rate in the brains, prion protein oxidative damage can be the crucial factor. Both theoretical consideration of the nature of protein radical reactions and a large body of previously unraveled feature of scrapie and prion diseases have provided multiple distinct lines of compelling evidence which persuasively support a suggestion that the infectious agents may be prion (free) radicals produced from protein oxidative damage. This paper describes that scrapie prions are most likely formed from prion radicals and oxidative species-mediated sequence-specific cross-linking of benign prion proteins.

关键词： prion oxidative damage sequence-specific free radicals variant of Creutzfeldt-Jakob disease (v CJD).

Radical scavenging and antibacterial activity of Arnebia benthamii methanol extract

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Asian Pacific Journal of Tropical Medicine 2012年第10期5卷 766-772页

作者： Showkat A Ganie Asima Jan Sabeera Muzaffar Bilal A Zargar Rabia Hamid M Afzal Zargar Department of Biochemistry University of Kashmir Department of Food Science and Technology University of Kashmir Department of Pharmaceutical Sciences University of Kashmir

Objective:To evaluate in vitro antioxidant and antibacterial activity of methanolic extract of Arnebia benthamii（***） whole ***:Plasmid damage was analyzed by agarose gell *** thymus DNA was monitored by TBARS ***, reducing power and lipid peroxidation was evaluated by using standard *** assay was monitored by disc diffusion ***:DPPH radical scavenging and hydroxyl radical scavenging potential of the plant revealed that the extract to be active radical ***(Fe3+-Fe2+) power and lipid peroxidation inhibition efficiency（TBARS assay） of the extract was also evaluated and the extract showed promising activity in preventing lipid peroxidation and might prevent oxidative damages to *** extract offered a significant protection against plasmid and calf thymus UNA damage induced by hydroxyl radicals. The extract was also evaluated on different bacterial strains and the maximum antibacterial activity was exhibited against Escherichia coli（***） when compared with standard drug. Conclusions:These findings demonstrate that the methanol extract of *** has excellent anti-oxidant activities and could be considered as a potential source of lead molecules for pharmaceutical industries.

关键词： Free radicals Lipid peroxidation DPPH TBARS DNA damage Antibacterial activity Arnebia benthamii

Exercise-induced oxidative stress:Friend or foe?

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Journal of Sport and Health Science 2020年第5期9卷 415-425页

作者： Scott K.Powers Rafael Deminice Mustafa Ozdemir Toshinori Yoshihara Matthew P.Bomkamp Hayden Hyatt Department of Applied Physiology and Kinesiology University of FloridaGainesvilleFL32608USA Department of Physical Education State University of LondrinaLondrina10011Brazil Department of Exercise and Sport Sciences Hacettepe UniversityAnkara06800Turkey Department of Exercise Physiology Juntendo UniversityTokyo270-1695Japan

The first report demonstrating that prolonged endurance exercise promotes oxidative stress in humans was published more than 4 decades *** this discovery,many ensuing investigations have corroborated the fact that muscular exercise increases the production of reactive oxygen species(ROS)and results in oxidative stress in numerous tissues including blood and skeletal *** several tissues may contribute to exercise-induced ROS production,it is predicted that muscular contractions stimulate ROS production in active muscle fibers and that skeletal muscle is a primary source of ROS production during *** contraction-induced ROS generation is associated with(1)oxidant damage in several tissues(e.g.,increased protein oxidation and lipid peroxidation),(2)accelerated muscle fatigue,and(3)activation of biochemical signaling pathways that contribute to exercise-induced adaptation in the contracting muscle *** our understanding of exercise and oxidative stress has advanced rapidly during the last decades,questions remain about whether exercise-induced increases in ROS production are beneficial or harmful to *** review addresses this issue by discussing the site(s)of oxidant production during exercise and detailing the health consequences of exercise-induced ROS production.

关键词： Hormesis Oxidants radicals Reactive oxygen species Skeletal muscle

Comparative investigation of the free radical scavenging potential and anticancer property of Diospyros blancoi(Ebenaceae)

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 410-417页

作者： Muhammad Ali Khan Mahbubur Rahman Nazmul Sardar Saiful Islam Arman Badrul Islam Jahangir Alam Khandakar Mamunur Rashid Golam Sadik AHM Khurshid Alam Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Department of Pharmacy University of Rajshahi Drugs and Toxins Research Division Bangladesh Council of Scientific and Industrial Research Product Development and Validation Department Square Pharmaceutical Limited Laboratory of Genetics Graduate School of BiostudiesKyoto University

Objective: To investigate the comparative effects of Diospyros blancoi(Ebenaceae)leaves(DBL), root bark(DBRB) and stem bark(DBSB) on free radicals and ***: The polyphenol contents, antioxidant and free radical scavenging properties were determined using standard spectrophotometric methods. Cytotoxicity and anticancer activities were performed on brine shrimp nauplii and Ehrlich ascite carcinoma cells, ***: Among the extracts, DBSB showed the highest total antioxidant capacity and reducing capacity on ferrous ion. Based on 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radical scavenging activities, DBSB showed(95.760 ± 0.343)% and(67.460 ± 2.641)%scavenging with IC50of(3.10 ± 0.17) and(50.00 ± 3.11) mg/m L, respectively. The IC50 values of standard butylated hydroxytoluene and catechin(CA) for 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals were(8.50 ± 0.25) and(75.00 ± 0.14) mg/m L,respectively suggesting that DBSB had a significant(P DBRB > CA > ***, the phenolic [(139.91 ± 3.924) mg gallic acid equivalent/g] and flavonoid contents[(412.00 ± 16.70) mg catechin equivalent/g)] of DBSB were higher than that of other extracts. In addition, the DBSB showed the moderate cytotoxic and anticancer ***: Our results indicate that Diospyros blancoi stem bark had the significant highest antioxidant and free radical scavenging properties as well as moderate anticancer ***, we assume that the anticancer activity of this plant can be, at least in part, attributed to its content in phenolic compounds as well as its significant free radical scavenging properties.

关键词： Diospyros blancoi Free radicals Polyphenols Antioxidant Cytotoxicity Anticancer

Investigation of antioxidant and anti-inflammatory activity of leaves of Dalbergia paniculata(Roxb)

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Asian Pacific Journal of Tropical Medicine 2012年第6期5卷 455-458页

作者： Ganga Rao B Madhu Kiran P Vijaya Raju AD Pharmacognosy and Phytochemistry A.U College of Pharmaceutical SciencesAndhra UniversityVisakhapatnamA.P.India-530 003 A.U College of Pharmaceutical Sciences Andhra UniversityVisakhapatnamA.PIndia-530 003

Objective:To investigate the antioxidant and anti-inflammatory activity of orally administered methanolic leaf extract of Dalbergia paniculala(***) in Carrageenan induced inflammation in ***:In vitro antioxidant activity was evaluated for superoxide radical, Hydroxyl radical and DPPH radical scavenging *** doses 200 mg/kg,400 mg/kg and 800 mg/kg of *** were tested for anti-inflammatory activity in Carrageenan induced rat paw edema model and paw thickness was measured every one hour up to 6 h. Results:The melhanolic leaf extract of *** produced dose dependent inhibition of Superoxide radical,Hydroxyl radical and OPPH *** Carrageenan induced inflammation model,all three doses produced significant percentage inhibition of rat paw edema and 800 mg/kg dose produced maximum percent inhibition of rat paw edema(47.83%) at 3h compared to control ***:In the present study we found that methanolic leaf extract of *** showed good in vitro antioxidant activity and in vivo anti-inflammatory activity in rats.

关键词： Anti-inflammatory activity Antioxidant activity Dalbergia paniculata Free radicals Carragenan Inflammation Edema

Photo-induced Electron Transfer Between Hypocrellins and BNAH

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Chinese Science Bulletin 1993年第14期38卷 1171-1176页

作者：安静仪蒋丽金 Institute of Photographic Chemistry Academia Sinica Beijing 100101 PRC

1 Introduction Much research work has been done on the mechanism of photo-induced reduction of quinone dyes by electron donors with visible light. Two ways to obtain the net two-electron reduction product QH^- bave been proposed. One is the direct two-electron transfer (electron-proton-electron transfer) within the complex and the other is the disproportionatioh of the semiquinone radical QH·formed by one-electron transfer.

关键词： hypocrellins hypocrellin semiquinone radicals electron transfer BNAH.