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pulmonary tuberculosis manifesting as‘tree-in-bud’opacities on chest radiography

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Family Medicine and Community Health 2013年第1期1卷 53-55页

作者： RUMI R.KHAJOTIA SANGEETHA POOVANESWARAN Internal Medicine and Pulmonology International Medical University Clinical SchoolMalaysia Internal Medicine International Medical University Clinical SchoolMalaysia

Background The‘tree-in-bud’pattern is an appearance typically seen on HRCT or thin-section computed tomography(CT)chest *** is characterized by small centrilobular nodules of soft-tissue attenuation connected to mul... 详细信息

关键词： pulmonary tuberculosis Tree-in-Bud pattern HRCT chest scan

Analysis of MIF,FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population

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Journal of Genetics and Genomics 2010年第4期37卷 257-264页

作者： Khalid Sadki Hoda Lamsyah Blanca Rueda ELmahfoud Akil Abderrahim Sadak Javier Martin Rajae El Aouad Human Genomic Unit Laboratory of ImmunologyNational Institute of Hygiene Department of Biology Faculty of SciencesUniversity Mohammed V-Rabat Agdal 10000 Department of Immunology Instituto de Parasitología y Biomedicina López-NeyraCSIC National Reference Laboratory of tuberculosis National Institute of Hygiene Immunology and Virology Department National Institute of Hygiene

In order to investigate the influence of functional polymorphisms of macrophage migration inhibitory factor （M/F）, Fcg receptors CD16A （FCGR3A） and CD32A （FCGR2A） genes on susceptibility to pulmonary tuberculosis （PTB） in the Moroccan population, we analyzed 123 patients with PTB and 154 healthy controls. The genotyping for M/F-173 （G/C）（rs755622）, FCGR2A- 131H/R （rs 1801274） and FCGR3A-158V/F （rs396991） was carried out using TaqMan SNP Genotyping Assay method. We found a statistically significant in- crease of the MIF-173CC homozygote genotype and M/F-173＂C allele frequencies in PTB patients compared with healthy controls （17.07% versus 5.84%, P = 0.003; and 35.37% versus 26.30%, P = 0.02; respectively）. In contrast, no association was observed between FCGR2A-131H/R and FCGR3A-158V/F polymorphisms and tuberculosis disease. Our finding suggests that M/F-173℃ variant may play an important role in the development of active tuberculosis.

关键词： FCGR MIF polymorphism susceptibility pulmonary tuberculosis Moroccan

Interleukin 17-Producing γδ T Cells Increased in Patients with Active pulmonary tuberculosis

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Cellular & Molecular Immunology 2008年第3期5卷 203-208页

作者： Meiyu Peng Zhaohua Wang Chunyan Yao Lina Jiang Qili Jin Jing Wang Baiqing Li Department of Immunology Bengbu Medical College and Anhui KeyLaboratory of Infection and Immunity at Bengbu Med cal College 2600Dong hai Avenue Bengbu Anhui 233030 China The Infectious Disease Hospital of Bengbu 160 Third Hongqi RoadBengbu Anhui 233000 China Department of Immunology Bengbu Medical College 2600 Dong Hal Avenue Bengbu Anhui 233030 China

Although it has been known that γδ T cells may play an important role in the immune response to infection of Mycobacterium tuberculosis （M. tb）, the mechanisms by which the γδ T cells participate in the innate and/or acquired immunity to tuberculosis （TB） have not been full elucidated. In the present study, 27 patients with active pulmonary TB and 16 healthy donors （HD） were performed. We found that proportion of IL-17-producing cells among lymphocyte was similar between TB patients and HD, whereas the proportions of γδ T cells in IL-17-producing cells （59.2%） and IL-17-producing cells in γδ T cells （19.4%） in peripheral blood were markedly increased in TB patients when compared to those in HD （43.9% and 7.7%, respectively）. In addition, the proportions of IFN-T-producing γδ T cells in TB patients were obviously lower than that in HD. Upon re-stimulated with M. tb heat-treated antigen （M. tb-HAg） in vitro, fewer IL-17-producing γδ T cells were generated from HD and TB patients, whereas IFN-T-producing γδ T cells were increased in TB patients compared to that in HD. Our findings in TB patients and healthy human were consistent with other murine investigation that the IL-17- producing γδ T cells were main source of IL-17 in mouse model of BCG infection, suggesting that γδ T cells might be involved in the formation of tubercular granuloma in pulmonary TB patients, but need further identification.

关键词： Mycobacterium tuberculosis γδ T cell IL-17 pulmonary tuberculosis

Cost Effectiveness of DOTS and Non-DOTS Strategies for Smear-positive pulmonary tuberculosis in Beijing

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Biomedical and Environmental Sciences 2000年第4期13卷 307-313页

作者： XU－QUN JINSHUI－GAO 等 Department of Preventive Medicine Jinzhou Medical Collegejinzhou 121001 China Information Center for Public Health Chinese Academy of Preventiv eMedicine Beijing 100050China

The cost effectiveness of DOTS (Directly Observed Treatment, short course) and non DOTS strategies for smear positive pulmonary tuberculosis in Beijing was evaluated. Cost calculation was based on the expenses of drugs, chest X ray films, sputum smears and cultures for the patients. Effectiveness of the intervention was assessed in two aspects: direct benefits to the patients treated and indirect benefits to the others through reduced transmission of tuberculosis; disability adjusted life of year (DALY) was used as an index. The results showed that one DALY could be saved with 45.7 Yuan by DOTS and 471.4 Yuan by non DOTS. DOTS is a good control strategy for smear positive tuberculosis.

关键词： pulmonary tuberculosis control strategy

3-to 24-month Follow-up on COVID-19 with pulmonary tuberculosis Survivors after Discharge:Results from a Prospective,Multicenter Study

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Biomedical and Environmental Sciences 2022年第12期35卷 1091-1099页

作者： WANG Jing Ya ZONG Xing Yu WU Gui Hui QI Yuan Lin LI Hui Zhen JI Xin Yu TONG Lin ZHANG Lei YANG Ming Bo YANG Pu Ye LI Ji Ke XIAO Fu Rong ZHANG Lin Song HU Yun Hong LIU Hong De XU Shou Fang SUN Sheng WU Wei MAO Ya LI Min Qing HOU Hao Hua GONG Zhao Yuan GUO Yang JIAO Li Wen QIN Jin WANG Ding Yi WANG Fang GUAN Li LIN Gang MA Yan WANG Yan Ping SHI Nan Nan Community Health Service Management Center Dongcheng DistrictBeijing 100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Public Health Clinical Center of Chengdu Chengdu 610066SichuanChina Yiyuan TCM Hospital Zibo 256199ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Xi’an Eighth Hospital Xi’an 710000ShaanxiChina Harbin Infectious Disease Hospital Harbin 150000HeilongjiangChina Hospital(T.C.M)Affiliated to Southwest Medical University Luzhou 646000SichuanChina Xingtai Hospital of Chinese Medicine Xingtai 054000HebeiChina Shijiazhuang Fifth Hospital Shijiazhuang 050000HebeiChina Jiamusi Infectious Disease Hospital Jiamusi 154000HeilongjiangChina Chengde Hospital of Traditional Chinese Medicine Chengde 067040HebeiChina Hanzhong Central Hospital Hanzhong 723000ShaanxiChina Ankang Hospital of Traditional Chinese Medicine Ankang 725000ShaanxiChina Department of Traditional Chinese medicine Dazhou Central HospitalDazhou 635000SichuanChina China National Medicines Corporation Ltd Beijing 100077China Beijing University of Chinese Medicine Beijing 101121China Infectious Disease Hospital of Heilongjiang Province Harbin 150030HeilongjiangChin

Objective Coronavirus disease 2019(COVID-19)and tuberculosis(TB)are major public health and social issues *** long-term follow-up of COVID-19 with pulmonary TB(PTB)survivors after discharge is *** study aimed to comprehensively describe clinical outcomes,including sequela and recurrence at 3,12,and 24 months after discharge,among COVID-19 with PTB *** From January 22,2020 to May 6,2022,with a follow-up by August 26,2022,a prospective,multicenter follow-up study was conducted on COVID-19 with PTB survivors after discharge in 13 hospitals from four provinces in *** outcomes,including sequela,recurrence of COVID-19,and PTB survivors,were collected via telephone and face-to-face interviews at 3,12,and 24 months after *** Thirty-two COVID-19 with PTB survivors were *** median age was 52(45,59)years,and 23(71.9%)were *** them,nearly two-thirds(62.5%)of the survivors were moderate,three(9.4%)were severe,and more than half(59.4%)had at least one comorbidity(PTB excluded).The proportion of COVID-19 survivors with at least one sequela symptom decreased from 40.6%at 3 months to 15.8%at 24 months,with anxiety having a higher proportion over a *** and amnesia recovered at the 12-month follow-up,while anxiety,fatigue,and trouble sleeping remained after ***,one(3.1%)case presented two recurrences of PTB and no re-positive COVID-19during the follow-up *** The proportion of long symptoms in COVID-19 with PTB survivors decreased over time,while nearly one in six still experience persistent symptoms with a higher proportion of *** recurrence of PTB and the psychological support of COVID-19 with PTB after discharge require more attention.

关键词： COVID-19 pulmonary tuberculosis Long-term Sequela Recurrence Re-positive

Reliability of urinary tests for antibody to Helicobacterpylori in patients with pulmonary tuberculosis

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World Journal of Gastroenterology 2005年第3期11卷 412-414页

作者： Takatsugu Yamamoto Taro Ishii Tomotaka Kawakami Yoko Sase Chiaki Horikawa Nozomu Aoki Masaki Sanaka Yasushi Kuyama Department of Internal Medicine Hospital attached to the Institute of Chemotherapy

AIM: Although the quality of currently available urinary tests for detecting antibody to Helicobacter pylori(H pylori) have been proved in some populations, the accuracy has not been studied regarding patients who suffer from pulmonary tuberculosis with multi-drug treatments. The present study was conducted to evaluate the accuracy of these urinary tests for antibody to H pylori in these patients. METHODS: Serum samples from 61 inpatients with pulmonary tuberculosis were tested using enzyme immunoassay, and urine samples were assayed by enzyme-linked immunosorbent assay method (URINELISA) and immunochromatography method (RAPIRAN). Medicines prescribed to the patients were recorded for medical charts, to evaluate the influences on the results of urinary tests. RESULTS: The sensitivity, specificity, and consistency of URINELJSA against the serum test were 93.1%, 65.6%, and 78.6% respectively, and those of RAPIRAN were 86.2%, 93.7%, and 90.1% respectively, which were almost equal to the data previously reported. Prescribed medicines had little influence on the results. CONCLUSION: The two urinary tests for detecting H pylori antibody have a diagnostic accuracy in patients with pulmonary tuberculosis given multiple anti-tuberculosis drugs.

关键词： Helicobacter pylori pulmonary tuberculosis Helicobacter pylori antibody Urinary tests

Association between depression and malnutrition in pulmonary tuberculosis patients:A cross-sectional study

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World Journal of Clinical Cases 2022年第14期10卷 4395-4403页

作者： Xue-E Fang Dan-Ping Chen Ling-Ling Tang Yan-Jun Mao Department of tuberculosis Shanghai Pulmonary Hospital Affiliated to Tongji UniversityShanghai 200000Shanghai ProvinceChina Department of Nursing Shanghai Pulmonary Hospital Affiliated to Tongji UniversityShanghai 200000Shanghai ProvinceChina

BACKGROUND Depression has been reported to be prevalent in patients with pulmonary tuberculosis(PTB).Moreover,several clinical symptoms of PTB and depression overlap,such as loss of appetite and ***,the association between depression and malnutrition in TB patients has not been fully *** To explore the association between depression and malnutrition in patients with *** This hospital-based cross-sectional study included patients with PTB in Shanghai pulmonary Hospital Affiliated to Tongji University from April 2019 to July *** Patient Health Questionnaire-9(PHQ-9)scale was used to evaluate *** cut-off value was set at 10,and the nutritional state was determined by the body mass index(BMI).In addition,the Quality of Life Instruments for Chronic Diseases was employed to establish the quality of life(QOL).Univariable analysis and multivariable analysis(forward mode)were implemented to identify the independent factors associated with *** A total of 328 PTB patients were screened for *** were excluded for missing demographic data,four excluded for missing nutrition status,and sixteen for missing QOL ***,300 PTB patients were subjected to *** found that depressive state was present in 225 PTB patients(75%).The ratio of malnutrition in the depressive PTB patients was 45.33%.Our results revealed significantly lower BMI,hemoglobin,and prealbumin in the depression group than in the control group(P<0.05).Moreover,the social status differed significantly(P<0.05)between the *** addition,glutamic pyruvic transaminase and glutamic oxaloacetic transaminase in the depression group were significantly higher than those in the control group(P<0.05).Multivariable logistic regression analysis showed that BMI[odds ratio(OR)=1.21,95%confidence interval(CI):1.163-1.257,P<0.001]and poor social function(OR=0.95,95%CI:0.926-0.974,P=0.038)were independently associated with ***

关键词： Depression pulmonary tuberculosis Malnutrition Quality of life Comorbidity China

Comparison of LAMP,GeneXpert,Mycobacterial Culture,Smear Microscopy,***,TBAg/PHA Ratio for Diagnosis of pulmonary tuberculosis

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Current Medical Science 2021年第5期41卷 1023-1028页

作者： Yan DENG Yi-fei DUAN Shu-pei GAO Jian-miao WANG Department of Respiratory and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Infection Control Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:To investigate the application value of loop-mediated isothermal amplification(LAMP),GeneXpert,mycobacterial culture,smear microscopy,***(TSPOT),ratio of TB-specific antigen to phytohemagglutinin(TBAg/PHA ratio)in the detection of mycobacterium tuberculosis in the bronchoalveolar lavage ***:A retrospective analysis was performed on the patients who underwent bronchoscopy from December 2018 to November 2019 in Tongji *** patients with positive tuberculosis culture or positive GeneXpert in bronchoalveolar lavage fluid were selected as the case group,and those without tuberculosis served as the control *** receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of LAMP,GeneXpert,culture,smear microscopy,TSPOT,and TBAg/PHA ***:For the patients with positive cultures as case,the sensitivity of LAMP,GeneXpert,smear microscopy,TSPOT and TBAg/PHA ratio was 73.49%,89.16%,25.30%,80.00%,33.85%,respectively,the specificity was 99.00%,100.00%,99.00%,86.00%,100.00%,respectively,the area under the ROC curve(AUC)was 0.849,0.938,0.633,0.830,0.669,*** the patients with positive GeneXpert as case,the sensitivity of LAMP,mycobacterial culture,smear microscopy,TSPOT and TBAg/PHA ratio was 73.20%,74.23%,22.68%,68.92%,29.73%,respectively,the specificity was 99.00%,100.00%,99.00%,86.00%,100.00%,respectively,the AUC was 0.853,0.878,0.623,0.775,0.649,***:The sensitivity of GeneXpert was *** sensitivity and diagnostic value of LAMP were slightly lower than those of GeneXpert,and were similar to tuberculosis *** sensitivity of smear microscopy was *** specificity of TSPOT was *** TBAg/PHA ratio>0.2 was used as a diagnostic index,the specificity was improved,but the sensitivity was low.

关键词： pulmonary tuberculosis bronchoalveolar lavage fluid loop-mediated isothermal amplification GeneXpert TSPOT

Prevalence and correlates of depressive symptoms in adult patients with pulmonary tuberculosis in the Southwest Region of Cameroon

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Infectious Diseases of Poverty 2016年第1期5卷 432-439页

作者： Jules Kehbila Cyril Jabea Ekabe Leopold Ndemnge Aminde Jean Jacques NNoubiap Peter Nde Fon Gottlieb Lobe Monekosso Department of Medicine Faculty of Health SciencesUniversity of BueaBueaCameroon Clinical Research Education Networking and ConsultancyBP 3480 DoualaCameroon School of Public Health Faculty of Medicine and Biomedical SciencesUniversity of QueenslandBrisbaneAustralia Department of Medicine Groote Schuur Hospital and University of Cape TownCape TownSouth Africa Medical Diagnostic Center YaoundéCameroon Department of Public Health and Hygiene Faculty of Health SciencesUniversity of BueaBueaCameroon Department of Medicine Faculty of Health SciencesUniversity of Buea and Global Health Dialogue FoundationBueaCameroon

Background:tuberculosis(TB)remains a global health challenge and depression is a significant contributor to the global burden of *** evidence suggests that there is an association between depressive symptoms and TB,lower adherence to treatment,and increased morbidity and ***,there is paucity of data regarding these associations in *** study aimed to determine the prevalence and correlates of depression in adult patients with pulmonary TB(PTB)in the Southwest Region of ***:A hospital-based cross-sectional study involving 265 patients with PTB was conducted from 2nd January to 31st March 2015 in the Limbe Regional Hospital and the Kumba District *** was diagnosed using the standard nine-item Patient Health Questionnaire,and classified as none,mild or *** regressions were used to investigate correlates of depression in these ***:Of the 265 patients(mean age 36.9±10 years)studied,136(51.3%)were *** prevalence of depression was 61.1%(95%CI:55.1–66.8),with a significant proportion(36.6%)having mild *** logistic regression analysis showed that being female(aOR=3.0,95%CI(1.7–5.5),P0.05),being on retreatment for TB(aOR=11.2,95%CI:5.2–31.1,P<0.001),having discontinued treatment(aOR=8.2,95%CI:1.1–23.3,P<0.05)and having a HIV/TB co-infection(aOR=2.5,95%CI:1.2–6.5,P<0.001)were factors associated with having a higher chance of being ***:Our study suggests that there is a high prevalence of depression among PTB patients,with more than one in two patients *** care for TB patients involving mental health practitioners is highly encouraged,especially for high-risk groups.

关键词： Prevalence Correlates Depression pulmonary tuberculosis Cameroon