Analysis of MIF,FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population

作     者：Khalid Sadki Hoda Lamsyah Blanca Rueda ELmahfoud Akil Abderrahim Sadak Javier Martin Rajae El Aouad 

作者机构：Human Genomic UnitLaboratory of ImmunologyNational Institute of Hygiene Department of BiologyFaculty of SciencesUniversity Mohammed V-Rabat Agdal 10000 Department of ImmunologyInstituto de Parasitología y Biomedicina López-NeyraCSIC National Reference Laboratory of TuberculosisNational Institute of Hygiene Immunology and Virology DepartmentNational Institute of Hygiene 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2010年第37卷第4期

页      面：257-264页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported in part by the grants SAF06-00398/CTS1880,Spain in another part by the National Institute of Hygiene,Rabat,Morocco 

主　　题：FCGR MIF polymorphism susceptibility pulmonary tuberculosis Moroccan 

摘      要：In order to investigate the influence of functional polymorphisms of macrophage migration inhibitory factor （M/F）, Fcg receptors CD16A （FCGR3A） and CD32A （FCGR2A） genes on susceptibility to pulmonary tuberculosis （PTB） in the Moroccan population, we analyzed 123 patients with PTB and 154 healthy controls. The genotyping for M/F-173 （G/C） （rs755622）, FCGR2A- 131H/R （rs 1801274） and FCGR3A-158V/F （rs396991） was carried out using TaqMan SNP Genotyping Assay method. We found a statistically significant in- crease of the MIF-173CC homozygote genotype and M/F-173＂C allele frequencies in PTB patients compared with healthy controls （17.07% versus 5.84%, P = 0.003; and 35.37% versus 26.30%, P = 0.02; respectively）. In contrast, no association was observed between FCGR2A-131H/R and FCGR3A-158V/F polymorphisms and tuberculosis disease. Our finding suggests that M/F-173℃ variant may play an important role in the development of active tuberculosis.