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Journal of Environmental Sciences 2023年第5期127卷 726-737页

作者： Jiahao Huang Lizi Liao Guowei Wang Zhongkun Du Zhengxing Wu Key Laboratory of Molecular Biophysics Ministry of EducationCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China School of Environmental Ecology and Biological Engineering Wuhan Institute of TechnologyWuhan 430205China Key Laboratory of Green Chemical Engineering Process of Ministry of Education Wuhan 430205China College of Resources and Environment Shandong Agricultural UniversityTaian 271018China

Fluoroquinolone antibiotics(FQs)that persist and bioaccumulate in the environment have aroused people’s great ***,we studied the adverse effects of FQs in soil animals of Caenorhabditis elegans via food-chronically *** result shows *** exposed to FQs exhibited reproductive toxicity with small-brood size and low-egg *** study the underlying mechanism,we conduct a deep investigation of enrofloxacin(ENR),one of the most frequently detected FQs,on nematodes which is one of commonly used animal indicator of soil *** concentration-effect curves simulated by the Hill model showed that the half effect concentrations(EC50)of ENR were(494.3±272.9)μmol/kg and(107.4±30.9)μmol/kg for the brood size and the hatchability,*** gene expression between the control and the ENR-exposure group enriched with the oxidative stress and cell apoptosis *** results together with the enzyme activity in oxidative stress and the cell corpses suggested that ENR-induced reproductive toxicity was related to germ cell apoptosis under oxidative *** risk quotients of some soil and livestock samples were calculated based on the threshold value of EC10 for the egg hatchability(2.65μmol/kg).The results indicated that there was possible reproductive toxicity on the nematodes in certain agricultural soils for the *** study suggested that chronic exposure to FQs at certain levels in environment would induce reproductive toxicity to the nematodes and might reduce the soil sustainability,alarming the environment risks of antibiotics abuse.

关键词： Environmental toxicity Nematodes Chronic exposure oxidative stress response Germ cell apoptosis

Bio-assembled smart nanocapsules for targeted delivery of KRAS shRNA and cancer cell bioimage

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Chinese Chemical Letters 2023年第1期34卷 270-273页

作者： Maonan Wang Zengchao Guo Jiayu Zeng Liu Liu Yihan Wang Jinpeng Wang Hongbing Lu Haijun Zhang Hui Jiang Xuemei Wang State Key Laboratory of Bioelectronics(Chien-Shiung Wu Lab) School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Department of Biomedical Engineering/Computer Application Fourth Military Medical UniversityXi’an 710032China Department of Oncology Zhongda HospitalMedical School of Southeast UniversityNanjing 210009China

The five-year survival rate for pancreatic cancer is less than 5%. However, the current clinical multimodal therapy combined with first-line chemotherapy drugs only increases the patient’s median survival from 5.0 months to 7.2 months. Consequently, a new strategy of cancer treatments is urgently needed to overcome this high-fatality disease. Through a series of biometric analyses, we found that KRAS is highly expressed in the tumor of pancreatic cancer patients, and this high expression is closely related to the poor prognosis of patients. It shows that inhibiting the expression of KRAS has great potential in gene therapy for pancreatic cancer. Given those above, we have exploited the possibility of targeted delivery of KRAS shRNA with the intelligent and bio-responsive nanomedicine to detect the special oxidative stress microenvironment of cancer cells and realize efficient cancer theranostics. Our observations demonstrate that by designing the smart self-assembled nanocapsules of melanin with fluorescent nanoclusters we can readily achieve the bio-recognition and bioimaging of cancer cells in biological solution or *** self-assembled nanocapsules can make a significant bio-response to the oxidative stress microenvironment of cancer cells and generate fluorescent zinc oxide Nanoclusters in situ for targeted cell bioimaging. Moreover, it can also readily facilitate cancer cell suppression through the targeted delivery of KRAS shRNA and low-temperature hyperthermia. This raises the possibility to provide a promising theranostics platform and self-assembled nanomedicine for targeted cancer diagnostics and treatments through special oxidative stress-responsive effects of cancer cells.

关键词： Smart bio-responsive nanocapsules Intelligent nanomedicine shRNA KRAS Fluorescent bioimaging oxidative stress response

Surviving the odds: From perception to survival of fungal phytopathogens under host-generated oxidative burst

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Plant Communications 2021年第3期2卷 38-54页

作者： Yeshveer Singh Athira Mohandas Nair Praveen Kumar Verma Plant Immunity Laboratory National Institute of Plant Genome ResearchAruna Asaf Ali MargNew Delhi 110067India School of Life Sciences Jawaharlal Nehru UniversityNew Delhi 110067India

Fungal phytopathogens pose a serious threat to global crop *** a handful of strategies are available to combat these fungal infections,and the increasing incidence of fungicide resistance is making the situation ***,the molecular understanding of plant–fungus interactions remains a primary focus of plant *** of the hallmarks of host–pathogen interactions is the overproduction of reactive oxygen species(ROS)as a plant defense mechanism,collectively termed the oxidative *** general,high accumulation of ROS restricts the growth of pathogenic organisms by causing localized cell death around the site of *** survive the oxidative burst and achieve successful host colonization,fungal phytopathogens employ intricate mechanisms for ROS perception,ROS neutralization,and protection from ROS-mediated ***,these countermeasures maintain the physiological redox homeostasis that is essential for cell *** addition to intracellular antioxidant systems,phytopathogenic fungi also deploy interesting effector-mediated mechanisms for extracellular ROS *** aspect of plant–pathogen interactions is significantly under-studied and provides enormous scope for future *** adaptive responses,broadly categorized into“escape”and“exploitation”mechanisms,are poorly *** this review,we discuss the oxidative stress response of filamentous fungi,their perception signaling,and recent insights that provide a comprehensive understanding of the distinct survival mechanisms of fungal pathogens in response to the host-generated oxidative burst.

关键词： reactive oxygen species(ROS) oxidative stress response fungal effectors stress signaling plant-pathogen interactions

Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators

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World Journal of Stem Cells 2024年第6期16卷 670-689页

作者： Ying Gao Mei-Fang Liu Yang Li Xi Liu Yu-Jie Cao Qian-Fa Long Jun Yu Jian-Ying Li Department of Respiratory and Critical Care Medicine Shaanxi Provincial Rehabilitation HospitalXi’an 710000Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Ningxia Medical University(The First People’s Hospital of Yinchuan)Yinchuan 750001Ningxia Hui Autonomous RegionChina School of Clinical Medicine Xi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Neurosurgery Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Emergency Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina

BACKGROUND Pulmonary fibrosis(PF)is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation,causing structural damage and lung *** cell therapy and mesenchymal stem cells-extracellular vesicles(MSC-EVs)offer new hope for PF *** To investigate the therapeutic potential of MSC-EVs in alleviating fibrosis,oxidative stress,and immune inflammation in A549 cells and bleomycin(BLM)-induced mouse *** The effect of MSC-EVs on A549 cells was assessed by fibrosis markers[collagen I andα-smooth muscle actin(α-SMA),oxidative stress regulators[nuclear factor E2-related factor 2(Nrf2)and heme oxygenase-1(HO-1),and inflammatory regu-lators[nuclear factor-kappaB(NF-κB)p65,interleukin(IL)-1β,and IL-2].Similarly,they were assessed in the lungs of mice where PF was induced by BLM after MSC-EV ***-EVs ion PF mice were detected by pathological staining and western ***-cell RNA sequencing was performed to investigate the effects of the MSC-EVs on gene expression profiles of macrophages after modeling in *** Transforming growth factor(TGF)-β1 enhanced fibrosis in A549 cells,significantly increasing collagen I andα-SMA ***,treatment with MSC-EVs demonstrated a remarkable alleviation of these ***,the expression of oxidative stress regulators,such as Nrf2 and HO-1,along with inflammatory regulators,including NF-κB p65 and IL-1β,were mitigated by MSC-EV ***,in a parallel manner,MSC-EVs exhibited a downregulatory impact on collagen deposition,oxidative stress injuries,and inflammatory-related cytokines in the lungs of mice with ***,the mRNA sequencing results suggested that BLM may induce PF in mice by upregulating pulmonary collagen fiber deposition and triggering an immune inflammatory *** findings collectively highlight the potential therapeutic efficacy of MSC-EVs in ameliorating fibrotic processes,oxidative stres

关键词： Mesenchymal stem cells Extracellular vesicles Pulmonary fibrosis oxidative stress response Epithelial-mesenchymal transition

Pregnane X receptor in drug-induced liver injury: Friend or foe?

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Liver Research 2018年第4期2卷 173-179页

作者： Amina I.Shehu Xiaochao Ma Center for Pharmacogenetics Department of Pharmaceutical SciencesSchool of PharmacyUniversity of PittsburghPittsburghPAUSA

The pregnane X receptor(PXR)is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism,endobiotic metabolism,oxidative stress response,apoptosis,inflammation,cell proliferation and *** activation promotes drug-induced liver injury(DILI)through its ability to increase the expression of phaseⅠand phaseⅡdrug metabolizing *** PXR also increases lipid synthesis and fatty acid uptake into the liver,leading to lipid accumulation and *** recent years,PXR has been explored as an important target in DILI and liver *** review will highlight the roles of PXR in modulating *** polymorphisms that have been associated with DILI will also be discussed.

关键词： Pregnane X receptor(PXR) Drug-induced liver injury(DILI) Drug metabolism Endobiotic metabolism oxidative stress response Apoptosis Inflammation Cell proliferation Cell regeneration

The effect of Jiangan Xiaozhi Formula on oxidative stress and inflammatory factors in patients with non-alcoholic fatty liver disease

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Clinical Research Communications 2024年第2期7卷 23-26页

作者： Si Wang Jia Zhu Ning Wang Jia-Bao Liao Yunnan University of Chinese Medicine Kunming 650599China Department of Emergency Jiaxing Hospital of Traditional Chinese MedicineJiaxing 314001China.

Objective:To investigate the effects of Jiangan Xiaozhi Formula(JGXZ)on oxidative stress and inflammatory factors in patients with non-alcoholic fatty liver disease(NAFLD).Methods:Between September 2022 and December 2023,our hospital admitted a total of 58 patients with *** patients were split into two groups at random:one for experimentation and the other for *** were 27 patients in the experimental group at the end,compared to 26 in the control group,reasonable exercise,weight management,lipid regulation,and oral polyene phosphatidylcholine capsules(PPC).The experimental group received JGXZ in addition to the above treatments for 12 consecutive *** in Traditional Chinese Medicine(TCM)syndrome scores,blood lipids,liver function indicators,the levels of oxidative stress markers,such as malondialdehyde(MDA),glutathione peroxidase(GSH-Px),and superoxide dismutase(SOD),as well as serum inflammatory factors,such as interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α),were measured both before and after ***:After treatment,both groups showed significant reductions in TCM syndrome scores(Poxidative stress markers(Presponses and regulating the balance of the oxidation-antioxidation system.

关键词： Jiangan Xiaozhi Formula non-alcoholic fatty liver disease oxidative stress response inflammatory factors