The effect of Jiangan Xiaozhi Formula on oxidative stress and inflammatory factors in patients with non-alcoholic fatty liver disease
作者机构：Yunnan University of Chinese MedicineKunming 650599China Department of EmergencyJiaxing Hospital of Traditional Chinese MedicineJiaxing 314001China.
出 版 物：《Clinical Research Communications》 (临床研究通讯)
年 卷 期：2024年第7卷第2期
页 面：23-26页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by National Natural Science Foundation of China,Youth Science Fund Project(82104820) Zhejiang Natural Science Foundation Project(LTGY23H270009) Applied Basic Research Project of Jiaxing Science and Technology Bureau(2023AY11035) Applied Basic Research Project of Jiaxing Science and Technology Bureau(2023AD11047)
主 题：Jiangan Xiaozhi Formula non-alcoholic fatty liver disease oxidative stress response inflammatory factors
摘 要：Objective:To investigate the effects of Jiangan Xiaozhi Formula(JGXZ)on oxidative stress and inflammatory factors in patients with non-alcoholic fatty liver disease(NAFLD).Methods:Between September 2022 and December 2023,our hospital admitted a total of 58 patients with *** patients were split into two groups at random:one for experimentation and the other for *** were 27 patients in the experimental group at the end,compared to 26 in the control group,reasonable exercise,weight management,lipid regulation,and oral polyene phosphatidylcholine capsules(PPC).The experimental group received JGXZ in addition to the above treatments for 12 consecutive *** in Traditional Chinese Medicine(TCM)syndrome scores,blood lipids,liver function indicators,the levels of oxidative stress markers,such as malondialdehyde(MDA),glutathione peroxidase(GSH-Px),and superoxide dismutase(SOD),as well as serum inflammatory factors,such as interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α),were measured both before and after ***:After treatment,both groups showed significant reductions in TCM syndrome scores(P0.05)and improvements in blood lipids,liver function indicators,inflammatory factors,and oxidative stress markers(P0.05).Improvements were noticeably better in the experimental group than in the control group.(P0.05).Conclusion:JGXZ can significantly improve clinical symptoms,regulate blood lipids,and protect liver function in patients with *** mechanism may be related to inhibiting inflammatory responses and regulating the balance of the oxidation-antioxidation system.
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