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Pretransplant absolute monocyte count in peripheral blood predicts posttransplant tumor prognosis in patients undergoing liver transplantation for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2014年第3期13卷 250-258页

作者： Young-Kyu Kim Seong Hoon Kim Seung-Duk Lee Soon-ae Lee Sang-Jae Park Center for Liver Cancer National Cancer Center323 Ilsan-ro Ilsandong-gu Goyang-si Gyeonggi-do Republic of Korea Department of Surgery College of Medicine Kangwon National University 1 Kangwondaehak-gilChuncheon-si Gangwon-do 200-701 Republic of Korea

BACKGROUND: Preoperative absolute monocyte count in peripheral blood(AMCPB) is closely associated with prognoses in not only various malignancies but also hepatocellular carcinoma(HCC). The purpose of this study was to evaluate whether pretransplant AMCPB predicts posttransplant outcomes in patients with HCC undergoing liver transplantation(LT).METHOD: We retrospectively analyzed relationships between clinicopathologic factors involving pretransplant AMCPB and tumor recurrence or survival in 256 patients who had undergone LT for HCC between January 2005 and April ***: ROC curve analysis showed that AMCPB >200/mm3was a risk factor for tumor recurrence; 43 patients showed higher AMCPB(>200/mm3), whereas 213 showed lower AMCPB(≤200/mm3) at the time of LT. On multivariate analysis,pretransplant high AMCPB, positive findings in pretransplant18F-FDG PET/CT, pathological maximal tumor size >5 cm,intrahepatic metastasis, moderately or poorly differentiated tumor and microvascular invasion were independent factors affecting recurrence-free survival. When we performed subgroup analysis based on the Milan criteria, high AMCPB was an independent factor for predicting HCC recurrence in patients with tumor beyond the Milan criteria(P=0.004), and not for patients within the ***: This study demonstrated that pretransplant AMCPB could predict tumor recurrence after LT for HCC,especially in patients with tumor beyond the Milan criteria.

关键词： liver transplantation hepatocellular carcinoma recurrence survival monocyte count

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Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis

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Acta Pharmacologica Sinica 2005年第9期26卷 1057-1062页

作者： En-zhi JIA~(2,5) Zhi-jian YANG~2 Biao YUAN~3 Xiao-ling ZANG~4 Rong-hu WANG~4 Tie-bing ZHU~2 Lian-sheng WANG~2 Bo CHEN~2 Wen-zhu MA~22 Departments of Cardiovascular Medicine,3 Chest Surgery and4 Clinical Laboratory,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China DepartmentsofCardiovascularMedicine Nanjing210029China

Aim:To explore the relationship between differential leucocyte count and coro-nary ***:The study population consisted of 507 consecu-tive patients(376 male and 131 female)who underwent coronary angiography forsuspected or known coronary *** patients’ smoking and drink-ing habits were investigated,and anthropometric measurements,serummeasurements,and hematological measurements were conducted for every *** severity of coronary atherosclerosis was defined by using Gensini’s ***-way ANOVA,Spearman’s correlation analysis,and multivariatestepwise linear regression analysis were employed to explore the relationshipbetween differential leucocyte count and coronary ***:One-way ANOVA indicated that the diastolic blood pressure,glucose,urea,creatinine,leukocyte count,neutrophil count,monocyte count,hemoglobin,and plateletcount differed among the groups according to Gensini’s score,the tertile valuesof which were used as cutoff ***’s correlation analysis suggestedthat Gensini’s score was significantly correlated with age,diastolic blood pressure,glucose,urea,creatinine,leukocyte count,neutrophil count,monocyte count,hemoglobin,and erythrocyte count,*** stepwise linearregression analysis show that neutrophil count(β=0.247,P=0.000),age(β=0.141,P=0.001),glucose(β=0.173,P=0.000),creatinine(β=0.088,P=0.063),hemoglobin(β=-0.168,P=0.013)and sex(men were coded as 1 and women were coded as 2;β=-0.121,P=0.012)were significantly independently associated with the Gensini’***:The independent association of neutrophil count with theangiographical characteristics of coronary atherosclerosis,as estimated byGensini’s score,strongly suggests that granulocytosis may play a role in thedevelopment of coronary atherosclerosis.

关键词： leukocyte count lymphocyte count monocyte count neutrophils coronary atherosclerosis Gensini’s score

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Elevated peripheral blood lymphocyteto-monocyte ratio predicts a favorable prognosis in the patients with metastatic nasopharyngeal carcinoma

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癌症 2015年第6期34卷 237-246页

作者： Rou Jiang Xiu-Yu Cai Zhong-Han Yang Yue Yan Xiong Zou Ling Guo Rui Sun Dong-Hua Luo Qiu-Yan Chen Pei-Yu Huang Yan-Qun Xiang Xing Lu Lin Wang Wei-Xiong Xia Hai-Qiang Mai Ming-Yuan Chen Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine 4. Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center 5. Department of Cancer Prevention 6. Department of Medical Oncology Sun Yat-sen University Cancer Center Department of Biochemistry Zhongshan School of MedicineSun Yat-sen University

Introduction:Patients with metastatic nasopharyngeal carcinoma(NPC)have variable survival *** have previously shown that an elevated peripheral blood lymphocyte-to-monocyte ratio(LMR)is associated with an increased metastatic risk in patients with primary *** present study aimed to investigate the prognostic value of pretreatment LMR in a large cohort of metastatic NPC ***:Clinical data of 672 patients with metastatic NPC diagnosed between January 2003 and December2009 were *** peripheral lymphocyte and monocyte counts were retrieved,and LMR was *** operating characteristic(ROC)curve analysis and univariate and multivariate COX proportional hazards analyses were performed to evaluate the association of LMR with overall survival(OS).Results:Univariate analysis revealed that an elevated absolute lymphocyte count(≥1.390×109/L)and LMR(≥2.475)as well as a decreased monocyte count(count(HR=0.77,95%CI=0.64–0.93,P=0.007),and monocyte count(HR=1.98,95%CI=1.63–2.41,P<0.001)were independent prognostic *** stratification analyses,only LMR remained a significant predictor of ***:We identified pretreatment LMR as an independent prognostic factor for patients with metastatic *** validation of our findings is needed.

关键词： Metastatic nasopharyngeal carcinoma Lymphocyte count monocyte count Lymphocyte-to-monocyte ratio Overall survival Prognosis

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monocyte-to-lymphocyte ratio as a prognostic factor in peripheral whole blood samples of colorectal cancer patients

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World Journal of Gastroenterology 2020年第31期26卷 4639-4655页

作者： Katarzyna Jakubowska Mariusz Koda Małgorzata Grudzinska Luiza Kanczuga-Koda Waldemar Famulski Department of Pathomorphology Comprehensive Cancer CentreBialystok 15027Poland Department of General Pathomorphology Medical University of BialystokBialystok 15027Poland Department of Medical Pathomorphology Medical University of BialystokBialystok 15027Poland

BACKGROUND Colorectal cancer is the third most common malignancy ***,it is critically important to identify new useful markers that can be easily obtained in routine *** is a crucial issue in the pathogenesis and development of *** To evaluate the prognostic value of absolute monocyte count,monocyte to lymphocyte ratio(MLR),the combination of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio(NLR-PLR),and combined platelet and neutrophilto-lymphocyte ratio(PLT-NLR)in peripheral blood samples of patients with colorectal cancer undergoing *** We conducted a retrospective study of 160 patients with colorectal cancer who underwent surgery,and 42 healthy *** status of absolute monocyte count,MLR,NLR-PLR and PLT-NLR was calculated on the basis of blood samples obtained before and after *** factors were examined in correlation with the type of tumour growth,tumour size,histological type,percentage of mucinous component,grade of malignancy,Tumour-Node-Metastasis stage,venous,lymphatic and perineural invasion of cancer cells,status of lymph node invasion and the presence of cancer cell *** Kaplan-Meier method and the long-rank test were used to compare survival *** determine independent prognostic factors,univariate and multivariate Cox proportional hazards regression models were *** The PLT-NLR status was correlated with tumour size and the presence of perineural invasion(P=0.015;P=-0.174,P=0.037).Moreover,high NLR-PLR and PLR-NLR ratios in the blood samples obtained after surgery were positively associated with histological type of cancer and percentage of the mucinous component(NLR-PLR:P=0.002;P=0.009;PLR-NLR status:P=0.002;P=0.007).The analysis of 5-year disease-free survival showed that the MLR of whole blood obtained after surgery[HR=2.903,95%CI:(1.368-6.158),P=0.005]and the status of lymph node metastasis[HR=0.813,95%CI:(0.653-1.013),P=0.050]were inde

关键词： monocyte count monocyte to lymphocyte ratio Platelet Neutrophil-tolymphocyte ratio Colorectal cancer Prognosis

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