Elevated peripheral blood lymphocyteto-monocyte ratio predicts a favorable prognosis in the patients with metastatic nasopharyngeal carcinoma

作     者：Rou Jiang Xiu-Yu Cai Zhong-Han Yang Yue Yan Xiong Zou Ling Guo Rui Sun Dong-Hua Luo Qiu-Yan Chen Pei-Yu Huang Yan-Qun Xiang Xing Lu Lin Wang Wei-Xiong Xia Hai-Qiang Mai Ming-Yuan Chen 

作者机构：Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine  4. Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center  5. Department of Cancer Prevention  6. Department of Medical Oncology Sun Yat-sen University Cancer Center Department of Biochemistry Zhongshan School of MedicineSun Yat-sen University 

出 版 物：《癌症》 (Chinese Journal of Cancer)

年 卷 期：2015年第34卷第6期

页      面：237-246页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from Sun Yat-sen University Clinical Research 5010 Program (201310) the National Natural Science Foundation of China (No. 81071890) 

主　　题：Metastatic nasopharyngeal carcinoma Lymphocyte count Monocyte count Lymphocyte-to-monocyte ratio Overall survival Prognosis 

摘      要：Introduction:Patients with metastatic nasopharyngeal carcinoma(NPC)have variable survival *** have previously shown that an elevated peripheral blood lymphocyte-to-monocyte ratio(LMR)is associated with an increased metastatic risk in patients with primary *** present study aimed to investigate the prognostic value of pretreatment LMR in a large cohort of metastatic NPC ***:Clinical data of 672 patients with metastatic NPC diagnosed between January 2003 and December2009 were *** peripheral lymphocyte and monocyte counts were retrieved,and LMR was *** operating characteristic(ROC)curve analysis and univariate and multivariate COX proportional hazards analyses were performed to evaluate the association of LMR with overall survival(OS).Results:Univariate analysis revealed that an elevated absolute lymphocyte count(≥1.390×109/L)and LMR(≥2.475)as well as a decreased monocyte count(0.665×109/L)were significantly associated with prolonged *** Cox proportional hazard analysis showed that LMR(hazard ratio[HR]=0.50,95%confidence interval[CI]=0.41–0.60,P0.001),absolute lymphocyte count(HR=0.77,95%CI=0.64–0.93,P=0.007),and monocyte count(HR=1.98,95%CI=1.63–2.41,P0.001)were independent prognostic *** stratification analyses,only LMR remained a significant predictor of ***:We identified pretreatment LMR as an independent prognostic factor for patients with metastatic *** validation of our findings is needed.