Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis

作     者：En-zhi JIA~(2,5) Zhi-jian YANG~2 Biao YUAN~3 Xiao-ling ZANG~4 Rong-hu WANG~4 Tie-bing ZHU~2 Lian-sheng WANG~2 Bo CHEN~2 Wen-zhu MA~22 Departments of Cardiovascular Medicine,3 Chest Surgery and4 Clinical Laboratory,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China 

作者机构：DepartmentsofCardiovascularMedicineNanjing210029China 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2005年第26卷第9期

页      面：1057-1062页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Natural Science Foundation of China(No 30400173) 

主　　题：leukocyte count lymphocyte count monocyte count neutrophils coronary atherosclerosis Gensini’s score 

摘      要：Aim:To explore the relationship between differential leucocyte count and coro-nary ***:The study population consisted of 507 consecu-tive patients(376 male and 131 female)who underwent coronary angiography forsuspected or known coronary *** patients’ smoking and drink-ing habits were investigated,and anthropometric measurements,serummeasurements,and hematological measurements were conducted for every *** severity of coronary atherosclerosis was defined by using Gensini’s ***-way ANOVA,Spearman’s correlation analysis,and multivariatestepwise linear regression analysis were employed to explore the relationshipbetween differential leucocyte count and coronary ***:One-way ANOVA indicated that the diastolic blood pressure,glucose,urea,creatinine,leukocyte count,neutrophil count,monocyte count,hemoglobin,and plateletcount differed among the groups according to Gensini’s score,the tertile valuesof which were used as cutoff ***’s correlation analysis suggestedthat Gensini’s score was significantly correlated with age,diastolic blood pressure,glucose,urea,creatinine,leukocyte count,neutrophil count,monocyte count,hemoglobin,and erythrocyte count,*** stepwise linearregression analysis show that neutrophil count(β=0.247,P=0.000),age(β=0.141,P=0.001),glucose(β=0.173,P=0.000),creatinine(β=0.088,P=0.063),hemoglobin(β=-0.168,P=0.013)and sex(men were coded as 1 and women were coded as 2;β=-0.121,P=0.012)were significantly independently associated with the Gensini’***:The independent association of neutrophil count with theangiographical characteristics of coronary atherosclerosis,as estimated byGensini’s score,strongly suggests that granulocytosis may play a role in thedevelopment of coronary atherosclerosis.