Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis
Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis作者机构:DepartmentsofCardiovascularMedicineNanjing210029China
出 版 物:《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期:2005年第26卷第9期
页 面:1057-1062页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金:the National Natural Science Foundation of China(No 30400173)
主 题:leukocyte count lymphocyte count monocyte count neutrophils coronary atherosclerosis Gensini’s score
摘 要:Aim:To explore the relationship between differential leucocyte count and coro-nary ***:The study population consisted of 507 consecu-tive patients(376 male and 131 female)who underwent coronary angiography forsuspected or known coronary *** patients’ smoking and drink-ing habits were investigated,and anthropometric measurements,serummeasurements,and hematological measurements were conducted for every *** severity of coronary atherosclerosis was defined by using Gensini’s ***-way ANOVA,Spearman’s correlation analysis,and multivariatestepwise linear regression analysis were employed to explore the relationshipbetween differential leucocyte count and coronary ***:One-way ANOVA indicated that the diastolic blood pressure,glucose,urea,creatinine,leukocyte count,neutrophil count,monocyte count,hemoglobin,and plateletcount differed among the groups according to Gensini’s score,the tertile valuesof which were used as cutoff ***’s correlation analysis suggestedthat Gensini’s score was significantly correlated with age,diastolic blood pressure,glucose,urea,creatinine,leukocyte count,neutrophil count,monocyte count,hemoglobin,and erythrocyte count,*** stepwise linearregression analysis show that neutrophil count(β=0.247,P=0.000),age(β=0.141,P=0.001),glucose(β=0.173,P=0.000),creatinine(β=0.088,P=0.063),hemoglobin(β=-0.168,P=0.013)and sex(men were coded as 1 and women were coded as 2;β=-0.121,P=0.012)were significantly independently associated with the Gensini’***:The independent association of neutrophil count with theangiographical characteristics of coronary atherosclerosis,as estimated byGensini’s score,strongly suggests that granulocytosis may play a role in thedevelopment of coronary atherosclerosis.