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Fatty acyl-CoA synthetase and meiotic cell cycle regulation

Fatty acyl-CoA synthetase and meiotic cell cycle regulation

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“细胞活动生命活力”——中国细胞生物学学会全体会员代...

作者： Huwei Wang,Jian Zhang Centre for Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing,China

Maternal factors play important roles during early animal *** of the major functions of maternal factors is to regulate meiotic cell cycle during *** report here a maternal gene Xacsl, whose mRNA is tightly localized in the vegetal cortex of Xenopus *** is a putative long chain fatty acyl-CoA synthetase,whose major products may include palmitoyl-CoA,myristoyl-CoA and *** of Xacsl mRNA by antisense oligos blocks the first cell cleavage of fertilized eggs, suggesting that Xacsl is essential for cell cycle *** blockage may be resulted from abnormal acceleration of G2/M transition during Xenopus meiosis,which was observed by the *** acceleration can be rescued by co-injection of in vitro transcribed Xacsl mRNAs,suggesting the enzyme activity of Xacsl is required for controlled release G2 oocytes into M *** propose that Xacsl may negatively regulate cell cycle progression during the meiosis in Xenopus.

关键词： Fatty acyl-CoA synthetase meiotic cell cycle Xenopus oocytes maternal

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Lipid modification and meiotic cell cycle regulation

Lipid modification and meiotic cell cycle regulation

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第三届细胞结构与功能的信号基础研讨会

作者： Huwei Wang and Jian Zhang Centre for developmental biology,Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

Maternal factors play important roles during early animal *** of the major functions of maternal factors is to regulate meiotic cell cycle during *** report here a maternal gene Xlacs,whose mRNA is tightly localized in the vegetal cortex of Xenopus *** is a putative long chain fatty acyl-CoA synthetase,whose major products may include palmitoyl-CoA, myristoyl-CoA and *** of Xlacs mRNA by antisense oligos blocks the first cell cleavage of fertilized eggs,suggesting that Xlacs is essential for cell cycle *** blockage may be resulted from abnormal acceleration of G2/M transition during Xenopus meiosis,which was observed by the *** acceleration can be rescued by co-injection of in vitro transcribed Xlacs mRNAs, suggesting the enzyme activity of XLACS is required for controlled release G2 oocytes into M *** propose that XLACS may negatively regulate cell cycle progression during the meiosis in Xenopus.

关键词： acyl-CoA synthetase meiotic cell cycle Xenopus oocytes maternal

来源： cnki会议评论

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