Lipid modification and meiotic cell cycle regulation
会议名称：《第三届细胞结构与功能的信号基础研讨会》
会议日期：2010年
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
关 键 词：acyl-CoA synthetase meiotic cell cycle Xenopus oocytes maternal
摘 要：Maternal factors play important roles during early animal *** of the major functions of maternal factors is to regulate meiotic cell cycle during *** report here a maternal gene Xlacs,whose mRNA is tightly localized in the vegetal cortex of Xenopus *** is a putative long chain fatty acyl-CoA synthetase,whose major products may include palmitoyl-CoA, myristoyl-CoA and *** of Xlacs mRNA by antisense oligos blocks the first cell cleavage of fertilized eggs,suggesting that Xlacs is essential for cell cycle *** blockage may be resulted from abnormal acceleration of G2/M transition during Xenopus meiosis,which was observed by the *** acceleration can be rescued by co-injection of in vitro transcribed Xlacs mRNAs, suggesting the enzyme activity of XLACS is required for controlled release G2 oocytes into M *** propose that XLACS may negatively regulate cell cycle progression during the meiosis in Xenopus.