Fatty acyl-CoA synthetase and meiotic cell cycle regulation
会议名称：《“细胞活动生命活力”——中国细胞生物学学会全体会员代...》
会议日期：2011年
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
关 键 词：Fatty acyl-CoA synthetase meiotic cell cycle Xenopus oocytes maternal
摘 要：Maternal factors play important roles during early animal *** of the major functions of maternal factors is to regulate meiotic cell cycle during *** report here a maternal gene Xacsl, whose mRNA is tightly localized in the vegetal cortex of Xenopus *** is a putative long chain fatty acyl-CoA synthetase,whose major products may include palmitoyl-CoA,myristoyl-CoA and *** of Xacsl mRNA by antisense oligos blocks the first cell cleavage of fertilized eggs, suggesting that Xacsl is essential for cell cycle *** blockage may be resulted from abnormal acceleration of G2/M transition during Xenopus meiosis,which was observed by the *** acceleration can be rescued by co-injection of in vitro transcribed Xacsl mRNAs,suggesting the enzyme activity of Xacsl is required for controlled release G2 oocytes into M *** propose that Xacsl may negatively regulate cell cycle progression during the meiosis in Xenopus.