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Current status of the efficacy and effectiveness of albendazole and mebendazole for the treatment of Ascaris lumbricoides in North-Western Indonesia

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Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 605-609页

作者： Inke Nadia Diniyanti Lubis Syahril Pasaribu Chairuddin Panusunan Lubis Department of Paediatrics School of MedicineUniversity of North SumateraMedanIndonesia

Objective:To investigate the efficacy and effectiveness of albendazole and mebendazole in the treatment of Ascaris lumbricoides(***) in the North-Western ***: 229 primary school children who were positive for *** in their stool were recruited in the study.123 children received single-dose of 400 mg albendazole and 106 children received single-dose 500 mg of *** 1 week,their stools were examined for the cure rate (CR) and egg reduction rate(ERR).Egg culture was also performed and observation was made on week-1,-3,-***:have shown a non-significant difference in CR 96.7%vs.100%:and ERR of 99.3%vs.100.0%for albendazole and mebendazole groups respectively(P>0.05).In-vitro egg culture has shown trends of decrease in the percentage of the unfertilized eggs and in≥2 cell eggs in both treatment groups(Pmebendazole group has shown a constant increase during the whole 4 weeks of culture from 7.5%to 28.3%(Pmebendazole in sterilizing *** eggs.

关键词： Ascaris lumbricoides Albendazole mebendazole Drug resistance

Development of nanocrystal formulation of mebendazole with improved dissolution and pharmacokinetic behaviors

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 122-123页

作者： Naofumi Hashimoto Kayo Yuminoki Haruka Takeuchi Chiaki Okada Setsunan University

Nanosizing by wet beads milling is a method to improve the solubility of poorly water soluble compounds[1,2].mebendazole(MBZ)is a well-known anthelmintic drug in wide clinical *** were some reports that MBZ had the anticancer effect in preclinical ***,the bioavailability of MEB is low(<10%)due to the poor solubility in water(0.5μg/mL).The present study aimed to develop the nanocrystal formulations of MEB to improve dissolution behavior and enhance oral absorption.

关键词： mebendazole Nanocrystal Wet beads milling Oral absorption

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THE EVALUATION OF THE EFFECT OF mebendazole ON TREATING ASCARIS LUMBRICOIDES AND TRICHURIS TRICHURA INFECTION WITH TWO KINDS OF THERAPY

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Journal of Pharmaceutical Analysis 1994年第1期8卷 60-62,66页

作者：魏润民熊印纲魏平杜贤彦徐波 Department of Epidemiology Xi'an Medical University Xi'an 710061 China

A total of 309 cases infected with ascariasis and trichuriasis were selected as subjects, of whom 177 cases received mebendazole tablet 500mg/d for the treatment of ascariasis and trichuriais,132 cases received mebendazole tablet 200mg/d for three days, Before and after the treatment, all the patients' feces were examined with Kato's technique, the results indicated that the cure rate of ascariasis was 71. 4% (70/98) in the experiment group and 78. 6% (66/84) in the control group respectively; There was no difference between the two groups (P > 0. 05 ). The cure rate of trichuriasis infection was 87. 5% (14/16 ) in the experimental group and 93. 3% (14/15 ) in the control group;There was also no difference between the two groups (P= 0. 401 ). But the cure rate of mixed infection of ascariasis and trichuriasis was 54. 0% (34/63) and 75. 8% (25/33) respectively; The cure rate of the experimental group was apparently lower than the that of the control group (P mebendazole tablet should be used the three-day therapy with a total dose of 600mg or 1200mg.

关键词： Trichuris trichura ascaris lumbricoides mebendazole evaluation

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Physicochemical Characterization and Solubility Enhancement Studies of mebendazole Solid Dispersions in Solvent Mixtures

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Journal of Pharmacy and Pharmacology 2016年第7期4卷 351-358页

作者： Pefia Maria Angeles Escalera Begofia Torrado Guillermo Natalini Paola Department of Biomedical Science Facultad de Farmacia Universidad de Alcal~ Alcal6 de Henares Madrid Spain Planta Piloto de Ingenieria Quimica (Plapiqui-Uns-Conicet) Bahia Blanca Argentina

Abstract： The objective was to obtain solid dispersion to improve the dissolution rate, solubility and oral absorption of MB （mebendazole）, poor water-soluble drugs. The new formulation was characterized by DSC （differential scanning calorimetry）, PXRD （powder X-ray diffraction）, FT-1R （fourier transform infrared spectroscopy） and STEM （scanning transmission electron microscopy） methods. Solid dispersions of MB with polyvinylpyrrolidone K-30 （PVP K30） were prepared by solvent evaporation method. The solubility of MB （original powder） and that of the solid dispersions was measured at 25℃ in ethanol-water. The aqueous solubility of MB was favoured by the presence of the polymer in solvent mixtures. Combination of solid dispersions with co-solvents increased the water solubility of MB in a larger extent that each method separately. Solubility parameter （o） was used to relate to solubility profiles. MB and the solid dispersions show a solubility curve with a single peak at 51 = 30.78 MPav2. Solid state characterizations indicated that the solid dispersion exist an amorphous material entrapped in polymer matrix getting highest improvement in wettability and solubility.

关键词： mebendazole PVP K30 solubility solid dispersion solubility parameter.

Effect of Albendazole and mebendazole on Hydatid Cyst of Mice

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Open Journal of Epidemiology 2017年第4期7卷 307-316页

作者： Ekram Ismail Fagiree Ismail Mohammed Bahaa Eldeen Ahmed Saad Aisha Abass Elsadig Department of Biology Alzaem Alazhari University Khartoum Sudan Alahlia University Khartoum Sudan Department of Radioisotopes of the Veterinary Research Center Khartoum Sudan

In the current study, hydatid cysts from livers and lungs of camels were obtained from Tambool slaughter house and protoscoleces were separated aseptically. 36-weeks-old Swiss mice (25 - 30 gram body weight males and females) were divided into two groups of 6 each: a prophylactic group dosed with 150 ml/kg of albendazole and mebendazole was given directly after injection with 2000 protoscoleces intraperitoneally for 10 consecutive days. The treated group was given a dose of 300 ml/kg of albendazole and mebendazole for 24 days with 4 days interval separated by 2 days and after 6 months of inoculation with protoscoleces, the two groups in addition to the control group were sacrificed and necropsied. The results revealed a significant difference in the development of hydatid cyst (p mebendazole compared to the control group, however, albendazole was highly efficacious than the mebendazole where the efficiency of albendazole reached 97% while the mebendazole efficiency rate was almost 50% which indicates that albendazole could be considered the drug of choice in the treatment of hydatid cyst.

关键词： Hydatid Cyst mebendazole Albendazole

Study on the interaction between palladium chloride and mebendazole by resonance Rayleigh scattering,second-order scattering and frequency doubling scattering spectra

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Study on the interaction between palladium chloride and Mebe...

Resonance Rayleigh scattering,frequency doubling scattering and absorption spectrum of the interaction between mebendazole and 12-tungstophosphoric acid and its analytical applications

第十七届全国光散射学术会议

作者： Jidong Yang Fengling Tian Wei Huang School of Chemistry and Chemical Engineering Southwest University School of Chemistry and Enviromental Engineering Chongqing Three Gorges University

＜正＞In pH 6.8～7.0 BR buffer solution,mebendazole（MBZ）could react with Pd（Ⅱ）to form a 1:1 ion-association complexes,which resulted in a significant enhancement of resonance Rayleigh scattering（RRS）, second-order scattering（SOS）and frequency doubling scattering（FDS）*** a certain range,the increments of scattering intensity（△I）were directly proportional to the concentrations of *** detection limits（3a）of MBZ were 1.55μg/L（RRS）,3.84μg/L（SOS）and 6.02μg/L（FDS）,*** method was applied to the determination of MBZ in tablets and human urine samples with satisfactory results.

关键词： mebendazole palladium chloride resonance Rayleigh scattering second-order scattering frequency doubling scattering

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Resonance Rayleigh scattering,frequency doubling scattering ...

甲苯咪唑(mebendazole)治疗旋毛虫病的疗效观察

第十七届全国光散射学术会议

作者： Fengling Tian Jidong Yang Wei Huang Shang Zhou Gengyang Yao School of Chemistry and Chemical Engineering Southwest University School of Chemistry and Chemical Engineering Yangtze Normal University School of Chemistry and Enviromental Engineering Chongqing Three Gorges University School of Chemistry and Chemical Engineering Yangtze Normal University

＜正＞In pH 1.0 HCI medium,mebendazole（MBZ）could react with TP to form 3:1 ion-association complex,which resulted in a significant enhancement of resonance Rayleigh scattering（RRS）,frequency doubling scattering（FDS）and absorption *** a certain range,the increments of scattering intensity（△I） and absorption（△A）were directly proportional to the concentrations of *** detection limits（3σ）of RRS, FDS and absorption are 0.56,0.86 and 130.16 ng/mL,*** method was applied to the determination of MBZ in tablets and human urine samples with satisfactory results.

关键词： mebendazole 12-tungstophosphoric acid(TP) Resonance Rayleigh scattering Frequency doubling scattering Absorption

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哈尔滨医科大学学报 1983年第4期 29-30页

作者：汪珏徐之杰李季哈尔滨医科大学二院传染科

旋毛虫病是人畜共患的传染病,国内云南西藏等地曾有报导。1980年春哈尔滨市100余人因吃“涮羊肉”而致本病流行。国外有人曾用甲苯咪唑治疗旋毛虫病获满意疗效。我们在国内首次试用国产甲苯咪唑治疗旋毛虫病,也获得良好效果,现将观察结... 详细信息

旋毛虫病是人畜共患的传染病,国内云南西藏等地曾有报导。1980年春哈尔滨市100余人因吃“涮羊肉”而致本病流行。国外有人曾用甲苯咪唑治疗旋毛虫病获满意疗效。我们在国内首次试用国产甲苯咪唑治疗旋毛虫病,也获得良好效果,现将观察结果报告如下。一、旋毛虫病的诊断依据 1、发病2～3周前有吃“涮羊肉”史; 2、有旋毛虫病主要临床表现,如发热、浮肿、肌痛、皮疹、无力等; 3、末梢血象嗜酸粒细胞增高; 4、血清旋毛虫环蚴试验阳性。

关键词：旋毛虫病疗效咪哩人畜共患病 mebendazole 甲苯咪哇

甲苯咪唑(mebendazole)糊剂对随机来源的猫的抗蠕虫作用

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实验动物科学 1985年第3期 99-100页

作者： Richaord E Bradley Larry J Peters 王玉阁

甲苯咪唑糊剂,剂量分别为22mg/kg,33mg/kg,口服三天,驱除猫自然感染的喇叭钩虫(Ancy los toma tabae forme)有高效。22mg/kg剂量疗效最高(精计驱虫率95.5％,虫体减少率98％)。同一产品,剂量分别为11mg/kg,22mg/kg和33mg/kg,对驱除自然... 详细信息

甲苯咪唑糊剂,剂量分别为22mg/kg,33mg/kg,口服三天,驱除猫自然感染的喇叭钩虫(Ancy los toma tabae forme)有高效。22mg/kg剂量疗效最高(精计驱虫率95.5％,虫体减少率98％)。同一产品,剂量分别为11mg/kg,22mg/kg和33mg/kg,对驱除自然感染的猫弓首蛔虫(Toxocara cati)疗效达100％。11mg/kg和22mg/kg,对常见丝虫一犬复孔绦虫(Dipylidium caninum)有高效。实验过程中,所有的猫均未见毒副作用或临床病状。作为医学生物学研究用的猫,大部分来源于控制饲养的和随机来源的猫。这些动物,几乎都存在各种肠道蠕虫感染。在将这些动物作为无病实验动物进行研究时,适当地治疗这些感染是关键的一步。甲苯咪唑(甲基—5—苯甲酰基—苯并咪唑—2—氨基甲酸盐酯)是一种苯并咪唑的衍生物,已作为一种广谱抗蠕虫药用于人和动物。已经证明,其作用方式是不可逆地阻断了线虫葡萄糖的摄取,但不影响哺乳动物的血糖水平作为马和猫的抗蠕虫药,甲苯咪唑在美国已有出售。

关键词：甲苯咪哇驱虫率 mebendazole 甲苯咪唑甲苯达唑犬复孔绦虫剖检虫体蛔虫减少率糊剂肠道蠕虫