Development of nanocrystal formulation of mebendazole with improved dissolution and pharmacokinetic behaviors
Development of nanocrystal formulation of mebendazole with improved dissolution and pharmacokinetic behaviors作者机构：Setsunan University
出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)
年 卷 期：2016年第11卷第1期
页 面：122-123页
学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Mebendazole Nanocrystal Wet beads milling Oral absorption
摘 要：Nanosizing by wet beads milling is a method to improve the solubility of poorly water soluble compounds[1,2].Mebendazole(MBZ)is a well-known anthelmintic drug in wide clinical *** were some reports that MBZ had the anticancer effect in preclinical ***,the bioavailability of MEB is low(10%)due to the poor solubility in water(0.5μg/mL).The present study aimed to develop the nanocrystal formulations of MEB to improve dissolution behavior and enhance oral absorption.
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