Current status of the efficacy and effectiveness of albendazole and mebendazole for the treatment of Ascaris lumbricoides in North-Western Indonesia

作     者：Inke Nadia Diniyanti Lubis Syahril Pasaribu Chairuddin Panusunan Lubis 

作者机构：Department of PaediatricsSchool of MedicineUniversity of North SumateraMedanIndonesia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第8期

页      面：605-609页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Ascaris lumbricoides Albendazole Mebendazole Drug resistance 

摘      要：Objective:To investigate the efficacy and effectiveness of albendazole and mebendazole in the treatment of Ascaris lumbricoides(***) in the North-Western ***: 229 primary school children who were positive for *** in their stool were recruited in the study.123 children received single-dose of 400 mg albendazole and 106 children received single-dose 500 mg of *** 1 week,their stools were examined for the cure rate (CR) and egg reduction rate(ERR).Egg culture was also performed and observation was made on week-1,-3,-***:have shown a non-significant difference in CR 96.7%vs.100%:and ERR of 99.3%vs.100.0%for albendazole and mebendazole groups respectively(P0.05).In-vitro egg culture has shown trends of decrease in the percentage of the unfertilized eggs and in≥2 cell eggs in both treatment groups(P0.05).The embryonated eggs from the albendazole groups has shown an increase from 7.3%on week-1 to 13.8%on week-4,whilst the mebendazole group has shown a constant increase during the whole 4 weeks of culture from 7.5%to 28.3%(P0.01). Conclusions:No evidence of drug resistance is noted so far from the area of North-Western part of *** addition,although both drugs showed incomplete ovicidal effects,single-dose albendazole is better than mebendazole in sterilizing *** eggs.