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Fifty-five cases of hepatic alveolar echinococcosis combined with lymph node metastasis:A retrospective study

World Journal of Gastroenterology 2024年第23期30卷 2981-2990页

作者： Yilizhati Aimaitijiang Tie-Min Jiang Ying-Mei Shao Tuerganaili Aji State Key Laboratory on Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaThe First Clinical CollegeXinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina The First Ward of Hepatobiliary and Pancreatic Surgery Tumor Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina Department of Hepatobiliary&Hydatid Diseases Digestive&Vascular Surgery CenterThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Xinjiang Clinical Research Center for Echinococcosis and Hepatobiliary Diseases The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina

BACKGROUND lymph node metastasis is a specific type of metastasis in hepatic alveolar echinococcosis(AE).Currently,there is a scarcity of describing the clinical characteristics and lymph node metastasis rules of patients with hepatic AE combined with lymph node metastasis and its mechanism and management are still *** hepatectomy combined with regional lymph node dissection is a better *** To analyse the clinical features of hepatic AE combined with lymph node metastasis to explore its treatment and *** A total of 623 patients with hepatic AE admitted to the First Affiliated Hospital of Xinjiang Medical University from 1 January 2012 to 1 January 2022 were retrospectively ***-five patients with combined lymph node metastasis were analysed for their clinical data,diagnosis and treatment methods,follow-up efficacy,and characteristics of lymph node ***,we comparatively analysed the lymph node metastasis rates at different *** variables are expressed as frequencies and percentages,and the analysis of difference was performed using theχ2 *** Bonferroni method was used for pairwise comparisons when statistical differences existed between multiple categorical *** A lymph node metastasis rate of 8.8%(55/623)was reported in patients with hepatic AE,with a female predilection(69.1%)and a statistically significant sex difference(χ2=8.018,P=0.005).Of the 55 patients with lymph node metastasis,72.7%had a parasite lesion,neighbouring organ invasion,and metastasis stage of P3N1M0 and above,of which 67.3%,78.2%,and 34.5%of hepatic AE lesions invaded the bile ducts,blood vessels,and distant metastases,*** rates of lymph node metastasis of 16.4%,21.7%,and 34.2%were reported for a preoperative abdominal ultrasound,magnetic resonance imaging,and computed tomography *** patients were intraoperatively suspected with enlarged lymph nodes and underwent radica

关键词： Echinococcosis Radical hepatectomy lymph node metastasis lymph node dissection Alveolar echinococcosis Hepatic

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Leptin-mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer

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Cancer Communications 2024年第8期44卷 855-878页

作者： Jian Xiao Shuqing Cao Jiawei Wang Pengyu Li Quan Cheng Xinyi Zhou Jiacheng Dong Yuan Li Xinyu Zhao Zekuan Xu Li Yang Department of General Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China

Background:lymph node metastasis(LNM)is the primary mode of metastasis in gastric cancer(GC).However,the precise mechanisms underlying this process remain *** cells necessitate lipid metabolic reprogramming to facilitate metastasis,yet the role of lipoprotein lipase(LPL),a pivotal enzyme involved in exogenous lipid uptake,remains uncertain in tumor ***,the aim of this study was to investigate the presence of lipid metabolic reprogramming during LNM of GC as well as the role of LPL in this ***:Intracellular lipid levels were quantified using oil red O staining,BODIPY 493/503 staining,and flow *** analysis was employed to identify alterations in intracellular lipid composition following LPL *** expression levels were assessed through immunohistochemistry,Western blotting,and enzyme-linked immunosorbent *** mouse popliteal LNM model was utilized to investigate differences in *** and mass spectrometry were employed to examine protein *** vitro phosphorylation assays and Phos-tag sodium dodecyl-sulfate polyacrylamide gel electrophoresis assays were conducted to detect angiopoietin-like protein 4(ANGPTL4)***:We identified that an elevated intracellular lipid level represents a crucial characteristic of node-positive(N+)GC and further demonstrated that a high-fat diet can expedite *** was found to be significantly overexpressed in N+GC tissues and shown to facilitate LNM by mediating dietary lipid uptake within GC ***,an obesity-related hormone,intercepted the effect exerted by ANGPTL4/Furin on LPL *** leptin binding to the leptin receptor could induce the activation of inositol-requiring enzyme-1(IRE1)kinase,leading to the phosphorylation of ANGPTL4 at the serine 30 residue and subsequently reducing its binding affinity with ***,our research revealed that LPL disrupted lipid homeostasis by elevating intrace

关键词： angiopoietin-like protein 4 leptin lipoprotein lipase lymph node metastasis prostaglandin E2

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Analysis of lymph node metastasis and survival prognosis in early gastric cancer patients: A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1637-1646页

作者： Dong-Yuan Liu Jin-Jin Hu Yong-Quan Zhou Ai-Rong Tan Department of General Surgery The 971st Hospital of Chinese People's Liberation ArmyQingdao 266071Shandong ProvinceChina Department of Chest Surgery Feicheng People's HospitalFeicheng 271600Shandong ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China Department of Oncology Qingdao Municipal HospitalQingdao 266000Shandong ProvinceChina

BACKGROUND Early gastric cancer(EGC)is a common malignant tumor of the digestive system,and its lymph node metastasis and survival prognosis have been *** retrospectively analyzing the clinical data of EGC patients,we can better under-stand the status of lymph node metastasis and its impact on survival and *** To evaluate the prognosis of EGC patients and the factors that affect lymph node METHODS The clinicopathological data of 1011 patients with EGC admitted to our hospital between January 2015 and December 2023 were collected in a retrospective cohort *** were 561 males and 450 *** mean age was 58±11 *** patient underwent radical *** status of lymph node metastasis in each group was determined according to the pathological examination results of surgical *** outcomes were as follows:(1)lymph node metastasis in EGC patients;(2)Analysis of influencing factors of lymph node metastasis in EGC;and(3)Analysis of prognostic factors in patients with *** distributed measurement data are expressed as mean±SD,and a t test was used for comparisons between *** data are expressed as absolute numbers or percentages,and the chi-square test was used for comparisons between *** data were compared using a nonparametric rank sum test.A log-rank test and a logistic regression model were used for univariate analysis.A logistic stepwise regression model and a Cox stepwise regression model were used for multivariate *** Kaplan-Meier method was used to calculate the survival rate and construct survival curves.A log-rank test was used for survival *** Analysis of influencing factors of lymph node metastasis in *** results of the multifactor analysis showed that tumor length and diameter,tumor site,tumor invasion depth,vascular thrombus,and tumor differentiation degree were independent influencing factors for lymph node metastasis in patients with EGC(odds ratios=1.80,1.49,2.6

关键词： Gastric neoplasms lymph node metastasis Prognosis Influencing factor Retrospective study

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Risk factors for lymph node metastasis in superficial esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第13期30卷 1810-1814页

作者： Yan-Bo Yu Department of Gastroenterology Laboratory of Translational GastroenterologyQilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina

In this editorial,we comment on the article by Wang et al published in the recent issue of the World Journal of Gastroenterology in *** focused on identifying risk factors for lymph node metastasis(LNM)in superficial esophageal squamous cell carcinoma(SESCC)patients and how to construct a simple and reliable clinical prediction model to assess the risk of LNM in SESCC patients,thereby helping to guide the selection of an appropriate treatment *** current standard treatment for SESCC is radical esophagectomy with lymph node ***,esophagectomy is associated with considerable morbidity and *** resection(ER)offers a safer and less invasive alternative to surgical resection and can enable the patient's quality of life to be maintained while providing a satisfactory ***,since ER is a localized treatment that does not allow for lymph node dissection,the risk of LNM in SESCC limits the effectiveness of *** LNM status can aid in determining whether patients with SESCC can be cured by ER without the need for additional *** studies have shown that tumor size,macroscopic type of tumor,degree of differentiation,depth of tumor invasion,and lymphovascular invasion are factors associated with LNM in patients with *** addition,tumor budding is commonly associated with LNM,recurrence,and distant metastasis,but this topic has been less covered in previous *** comprehensively evaluating the above risk factors for LNM,useful evidence can be obtained for doctors to select appropriate treatments for SESCC patients.

关键词： Superficial esophageal squamous cell carcinoma Endoscopic resection lymph node metastasis Risk factors Tumor budding Predictive model

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GLI1 and PTTG1 expression in colorectal carcinoma patients undergoing radical surgery and their correlation with lymph node metastasis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1328-1335页

作者： Feng Cao Yang-Yan Chen Hong-Cheng Wang Department of Care Section Beijing Geriatric HospitalBeijing 100095China Research Department Shanghai Zhangjiang Institute of Medical InnovationShanghai 200000China Care Department Beijing Geriatric HospitalBeijing 100095China

BACKGROUND Few studies have investigated the expression of GLI1 and PTTG1 in patients undergoing radical surgery for colorectal carcinoma(CRC)and their association with lymph node metastasis(LNM).Therefore,more relevant studies and analyses need to be *** To explore GLI1 and PTTG1 expression in patients undergoing radical surgery for CRC and their correlation with *** This study selected 103 patients with CRC admitted to our hospital between April 2020 and April *** specimens of CRC and adjacent tissues were collected to determine the positive rates and expression levels of GLI1 and *** correlation of the two genes with patients’clinicopathological data(e.g.,LNM)was explored,and differences in GLI1 and PTTG1 expression between patients with LNM and those without were *** operating characteristic(ROC)curves were plotted to evaluate the predictive potential of the two genes for LNM in patients with *** Significantly higher positive rates and expression levels of GLI1 and PTTG1 wereobserved in CRC tissue samples compared with adjacent ***1 and PTTG1 were strongly linked to LNM in patients undergoing radical surgery for CRC,with higher GLI1 and PTTG1 levels found in patients with LNM than in those *** areas under the ROC curve of GLI1 and PTTG1 in assessing LNM in patients with CRC were 0.824 and 0.811,*** GLI1 and PTTG1 expression was upregulated in patients undergoing radical surgery for CRC and are significantly related to LNM in these ***,high GLI1 and PTTG1 expression can indicate LNM in patients with CRC undergoing radical *** expression of both genes has certain diagnostic and therapeutic significance.

关键词： Colorectal carcinoma GLI1 PTTG1 Radical resection lymph node metastasis

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Predictive value of machine learning models for lymph node metastasis in gastric cancer: A two-center study

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 85-94页

作者： Tong Lu Miao Lu Dong Wu Yuan-Yuan Ding Hao-Nan Liu Tao-Tao Li Da-Qing Song Department of Emergency Medicine Jining No.1 People’s HospitalJining 272000Shandong ProvinceChina Wuxi Mental Health Center Wuxi 214000Jiangsu ProvinceChina Department of Gastroenterology Jining No.1 People’s HospitalJining 272000Shandong ProvinceChina Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors in the digestive system,ranking sixth in incidence and fourth in mortality *** 42.5%of metastatic lymph nodes in gastric cancer belong to nodule type and peripheral type,the application of imaging diagnosis is *** To establish models for predicting the risk of lymph node metastasis in gastric cancer patients using machine learning(ML)algorithms and to evaluate their pre-dictive performance in clinical *** Data of a total of 369 patients who underwent radical gastrectomy at the Depart-ment of General Surgery of Affiliated Hospital of Xuzhou Medical University(Xuzhou,China)from March 2016 to November 2019 were collected and retro-spectively analyzed as the training *** addition,data of 123 patients who underwent radical gastrectomy at the Department of General Surgery of Jining First People’s Hospital(Jining,China)were collected and analyzed as the verifi-cation *** ML models,including decision tree,random forest,support vector machine(SVM),gradient boosting machine,naive Bayes,neural network,and logistic regression,were developed to evaluate the occurrence of lymph node metastasis in patients with gastric *** ML models were established fo-llowing ten cross-validation iterations using the training dataset,and subsequently,each model was assessed using the test *** models’performance was evaluated by comparing the area under the receiver operating characteristic curve of each *** Among the seven ML models,except for SVM,the other ones exhibited higher accuracy and reliability,and the influences of various risk factors on the models are *** The ML models developed exhibit strong predictive capabilities for lymph node metastasis in gastric cancer,which can aid in personalized clinical diagnosis and treatment.

关键词： Machine learning Prediction model Gastric cancer lymph node metastasis

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Targeted Micellar Phthalocyanine for lymph node metastasis Homing and Photothermal Therapy in an Orthotopic Colorectal Tumor Model

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Nano-Micro Letters 2021年第11期13卷 1-17页

作者： Hai‑Yi Feng Yihang Yuan Yunpeng Zhang Hai‑Jun Liu Xiao Dong Si‑Cong Yang Xue‑Liang Liu Xing Lai Mao‑Hua Zhu Jue Wang Qin Lu Quanjun Lin Hong‑Zhuan Chen Jonathan F.Lovell Peng Sun Chao Fang Hongqiao International Institute of Medicine Tongren Hospital and State Key Laboratory of Oncogenes and Related GenesDepartment of Pharmacology and Chemical BiologyShanghai Jiao Tong University School of Medicine(SJTU-SM)Shanghai 200025People’s Republic of China Department of General Surgery Tongren HospitalSJTU-SMShanghai 200336People’s Republic of China Institute of Interdisciplinary Integrative Biomedical Research Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203People’s Republic of China Department of Biomedical Engineering University at BuffaloState University of New YorkBuffaloNY 14260USA

Tumor lymph node(LN)metastasis seriously affects the treatment *** have shown that nanoparticles with size of sub-50 nm can directly penetrate into LN metastases after intravenous ***,we speculate through introducing targeting capacity,the nanoparticle accumulation in LN metastases would be further enhanced for improved local treatment such as photothermal *** micelles(<50 nm)were formulated using a unique surfactantstripping approach that yielded concentrated phthalocyanines with strong near-infrared *** micellar phthalocyanine(T-MP)was an effective photothermal transducer and ablated HT-29 cells in vitro.A HER2-expressing colorectal cancer cell line(HT-29)was used to establish an orthotopic mouse model that developed metastatic disease in mesenteric sentinel LN.T-MP accumulated more in the LN metastases compared to the micelles conjugated with control *** surgical resection of the primary tumor,minimally invasive photothermal treatment of the metastatic LN with T-MP,but not the control micelles,extended mouse *** findings demonstrate for the first time that targeted small-sized nanoparticles have potential to enable superior paradigms for dealing with LN metastases.

关键词： lymph node metastasis Photothermal therapy Trastuzumab Phthalocyanine Micelles

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Correlation between mitochondrial TRAP-1 expression and lymph node metastasis in colorectal cancer

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World Journal of Gastroenterology 2012年第41期18卷 5965-5971页

作者： Jing-Yan Gao Bao-Rong Song Jun-Jie Peng Yuan-Ming Lu Department of Colorectal Cancer Fudan University ShanghaiCancer Center Shanghai Medical College Fudan UniversityShanghai 200032 China Department of Human Anatomy and Histo-Em-bryology Shanghai Medical College Fudan University Shanghai200032 China Department of Oncology Shanghai MedicalCollege Fudan University Shanghai 200032 China

AIM： To evaluate the effect of mitochondrial tumor ne- crosis factor receptor-associated protein-1 （TRAP-l） on the lymph node metastasis （LNM） in Chinese colorectal cancer （CRC） patients, and develop potential LNM- associated biomarkers for CRC using quantitative real- time polymerase chain reaction （RT-PCR） analysis. METHODS： Differences in mitochondrial TRAP-1 gene expression between primary CRC with LNM （LNM CRC） and without LNM （non-LNM CRC） were assessed in 96 Chinese colorectal carcinoma samples using quantita- tive RT-PCR analysis, Western blotting, and confirmed with immunohistochemical assay. The relationship between clinicopathological parameters and potential diaclnostic biomarkers was also ***： TRAP-1 was significantly upregulated in LNM CRC compared with non-LNM CRC, which was confirmed by RT-PCR, Western blotting and immuno- histochemical assay. The expression of TRAP-1 in two different metastatic potential human colorectal cancer cell lines, LoVo and HT29, was analyzed with Western blotting. The expression level of TRAP-1 was dramati- cally higher in LoVo than in HT29. Overexpression of TRAP-1 was significantly associated with LNM （90.2% in LNM group vs 22% in non-LNM group, P 〈 0.001）, the advanced tumor node metastasis stage （89.1% in LNM group vs 26.9% in non-LNM group, P 〈 0.001）, the increased 5-year recurrence rate （82.7% in LNM group vs 22.6% in non-LNM group, P 〈 0.001） and the decreased 5-year overall survival rate （48.4% in LNM vs 83.2% in non-LNM group, P 〈 0.001）. Univariate and multivariate analyses indicated that TRAP-1 expression was an independent prognostic factor for recurrence and survival of CRC patients （Hazard ratio of 2.445 in recurrence, P = 0.017; 2.867 in survival, P = 0.028）. CONCLUSION： Mitochondria TRAP-1 affects the lymph node metastasis in CRC, and may be a potential bio- marker for LNM and a prognostic factor in CRC. Over- expression of TRAP-1 is a predictive factor for the poor outcome of colorectal cancer

关键词： Colorectal cancer lymph node metastasis Prognosis Quantitative real-time polymerase chain reaction analysis Hsp90 family Mitochondria tumor necrosis factor receptor-associated protein-1

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^(68)Ga-labeled amphiphilic polymer nanoparticles for PET imaging of sentinel lymph node metastasis

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Regenerative Biomaterials 2023年第1期10卷 799-807页

作者： Qin Chen Xiaomin Fu Huawei Cai Shengxiang Fu Zhongyuan Cai Mufeng Li Xiaoai Wu Rong Tian Hua Ai National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Nuclear Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Radiology West China HospitalSichuan UniversityChengdu 610041China

Precise diagnosis of lymph node metastasis is important for therapeutic regimen planning,prognosis analysis and probably better outcomes for cancer *** this work,^(68)Ga-labeled amphiphilic alternating copolymers nanoparticles with different rigid ligands were synthesized as positron emission tomography(PET)probes for lymph node metastasis *** labeling efficiency and stability of nanoparticles was improved with increased rigidity of coordination ***(^(68)Ga-L-MDI-PEG)nanoparticles(PU(^(68)Ga-L-MDI-PEG)NPs)with the strongest rigidity of coordination unit exhibited the lowest critical micelle concentration,the best^(68)Ga labeling efficiency and *** in vivo lymph node metastasis imaging,PU(^(68)Ga-L-MDI-PEG)NPs led to different accumulations in normal lymph nodes(N-LN)and tumor metastasized sentinel lymph nodes(T-SLN),which resulted in different PET signal presentation,making it feasible to differentiate N-LN from *** comparison,small molecule probe^(68)GaL had poor lymph node accumulation,not only making it difficult to find lymph nodes on PET/computed tomography scan,but also tough to distinguish N-LN from metastatic ***,this work provides a reference for design of^(68)Ga labeled polymeric nanoparticles with high chelation efficiency and stability,as sensitive PET probes for lymph node imaging.

关键词： amphiphilic alternating copolymers rigidity PET lymph node metastasis labeling efficiency

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STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer

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World Journal of Gastroenterology 2010年第42期16卷 5380-5387页

作者： Jing-Yu Deng Xiang-Yu Liu Han Liang Dan Sun Yi Pan Depar tment of Gastric Oncology Division Tianjin Medical University Cancer Hospital and City Key Laboratory of Tianjin Cance r CenterTianjin 300060China Lung Cancer Institute Tianjin Medical University GeneralHospitalTianjin 300060China Department of Pathology Tianjin Medical Unive rsityCancer HospitalTianjin 300060China

AIM:To investigate the correlation between gastric cancer growth and signal transducer and activator of transcription-3(STAT3) ***:We assessed the expressions of STAT3,phosphor-STAT3(pSTAT3),suppressor of cytokine signaling-1(SOCS-1),survivin and Bcl-2 in gastric cancer patients after gastrectomy by immunohistochemical *** addition,in situ hybridization was used to further demonstrate the mRNA expression of STAT3 in gastric ***:With the univariate analysis,expressions of STAT3,pSTAT3,SOCS-1,survivin and Bcl-2,the size of primary tumor and the lymph node metastasis were found to be associated with the overall survival(OS) of gastric cancer ***,only pSTAT3 expression and the lymph node metastasis were identified as the independent factors of OS of gastric cancer with multivariate ***3 expression was correlated with the lymph node *** were positive correlations between expressions of STAT3,survivin,Bcl-2 and pSTAT3 in gastric cancer,whereas there was negative correlation between STAT3 expression and SOCS-1 expression in gastric ***:STAT3 can transform into pSTAT3 to promote the survival and inhibit the apoptosis of gastric cancer ***-1 might be the valid molecular antagonist to inhibit the STAT3 expression in gastric cancer.

关键词： Gastric cancer Signal transducer and activator of transcription-3 lymph node metastasis Apoptosis Survival analysis

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