^(68)Ga-labeled amphiphilic polymer nanoparticles for PET imaging of sentinel lymph node metastasis

作     者：Qin Chen Xiaomin Fu Huawei Cai Shengxiang Fu Zhongyuan Cai Mufeng Li Xiaoai Wu Rong Tian Hua Ai 

作者机构：National Engineering Research Center for BiomaterialsSichuan UniversityChengdu 610064China Department of Nuclear MedicineWest China HospitalSichuan UniversityChengdu 610041China Department of RadiologyWest China HospitalSichuan UniversityChengdu 610041China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2023年第10卷第1期

页      面：799-807页

核心收录：

学科分类：1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(NSFC,Nos.51903174 and 52073192) Innovative Research Groups of the National Natural Science Foundation of China(81621003) 

主　　题：amphiphilic alternating copolymers rigidity PET lymph node metastasis labeling efficiency 

摘      要：Precise diagnosis of lymph node metastasis is important for therapeutic regimen planning,prognosis analysis and probably better outcomes for cancer *** this work,^(68)Ga-labeled amphiphilic alternating copolymers nanoparticles with different rigid ligands were synthesized as positron emission tomography(PET)probes for lymph node metastasis *** labeling efficiency and stability of nanoparticles was improved with increased rigidity of coordination ***(^(68)Ga-L-MDI-PEG)nanoparticles(PU(^(68)Ga-L-MDI-PEG)NPs)with the strongest rigidity of coordination unit exhibited the lowest critical micelle concentration,the best^(68)Ga labeling efficiency and *** in vivo lymph node metastasis imaging,PU(^(68)Ga-L-MDI-PEG)NPs led to different accumulations in normal lymph nodes(N-LN)and tumor metastasized sentinel lymph nodes(T-SLN),which resulted in different PET signal presentation,making it feasible to differentiate N-LN from *** comparison,small molecule probe^(68)GaL had poor lymph node accumulation,not only making it difficult to find lymph nodes on PET/computed tomography scan,but also tough to distinguish N-LN from metastatic ***,this work provides a reference for design of^(68)Ga labeled polymeric nanoparticles with high chelation efficiency and stability,as sensitive PET probes for lymph node imaging.