GLI1 and PTTG1 expression in colorectal carcinoma patients undergoing radical surgery and their correlation with lymph node metastasis
作者机构：Department of Care SectionBeijing Geriatric HospitalBeijing 100095China Research DepartmentShanghai Zhangjiang Institute of Medical InnovationShanghai 200000China Care DepartmentBeijing Geriatric HospitalBeijing 100095China
出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)
年 卷 期：2024年第16卷第5期
页 面：1328-1335页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Colorectal carcinoma GLI1 PTTG1 Radical resection Lymph node metastasis
摘 要：BACKGROUND Few studies have investigated the expression of GLI1 and PTTG1 in patients undergoing radical surgery for colorectal carcinoma(CRC)and their association with lymph node metastasis(LNM).Therefore,more relevant studies and analyses need to be *** To explore GLI1 and PTTG1 expression in patients undergoing radical surgery for CRC and their correlation with *** This study selected 103 patients with CRC admitted to our hospital between April 2020 and April *** specimens of CRC and adjacent tissues were collected to determine the positive rates and expression levels of GLI1 and *** correlation of the two genes with patients’clinicopathological data(e.g.,LNM)was explored,and differences in GLI1 and PTTG1 expression between patients with LNM and those without were *** operating characteristic(ROC)curves were plotted to evaluate the predictive potential of the two genes for LNM in patients with *** Significantly higher positive rates and expression levels of GLI1 and PTTG1 wereobserved in CRC tissue samples compared with adjacent ***1 and PTTG1 were strongly linked to LNM in patients undergoing radical surgery for CRC,with higher GLI1 and PTTG1 levels found in patients with LNM than in those *** areas under the ROC curve of GLI1 and PTTG1 in assessing LNM in patients with CRC were 0.824 and 0.811,*** GLI1 and PTTG1 expression was upregulated in patients undergoing radical surgery for CRC and are significantly related to LNM in these ***,high GLI1 and PTTG1 expression can indicate LNM in patients with CRC undergoing radical *** expression of both genes has certain diagnostic and therapeutic significance.
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