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Optimal design of label-free silicon “lab on a chip” biosensors

Progress in Natural Science:Materials International 2013年第5期23卷 481-486页

作者： Yaping Zhang Faculty of Engineering The University of Nottingham Ningbo

This paper reported the optimal design of label-free silicon on insulator(SOI) "lab on a chip"*** devices are designed on the basis of the evanescent field detection principles and interferometer *** well-established silicon device process technology can be applied to fabricate and test these biosensor *** addition,these devices can be monolithically integrated with CMOS electronics and *** these biosensor devices,multi-mode interferometer(MMI) was employed to combine many stand-alone biosensors to form chip-level biosensor arrays,which enable realtime and label-free monitoring and parallel detection of various analytes in multiple test *** sensing and detection technology features the highest detection sensitivity,which can detect analytes at extremely low concentrations *** research can lead to innovative commercial development of the new generation of high sensitivity biosensors for a wide range of applications in many fields,such as environmental monitoring,food security control,medical and biological applications.

关键词： Mach-Zehnder interferometer Young interferometer lab on a chip Arrayed biosensors Evanescent field detection

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Toward integrated detection and graphene-based removal of contaminants in a lab-on-a-chip platform

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Nano Research 2017年第7期10卷 2296-2310页

作者： Andrzej Chalupniak Arben Merkoci Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Bellaterra 08193 Barcelona Spain ICREA Pg. Lluis Companys 23 08070 Barcelona Spain

A novel miniaturized microfluidic platform was developed for the simultaneous detection and removal of polybrominated diphenyl ethers （PBDEs）. The platform consists of a polydimethylsiloxane （PDMS） microfluidic chip for an immunoreaction step, a PDMS chip with an integrated screen-printed electrode （SPCE） for detection, and a PDMS-reduced graphene oxide （rGO） chip for physical adsorption and subsequent removal of PBDE residues. The detection was based on competitive immunoassay-linked binding between PBDE and PBDE modified with horseradish peroxidase （HRP-PBDE） followed by the monitoring of enzymatic oxidation of o-aminophenol （o-AP） using square wave anodic stripping voltammetry （SW-ASV）. PBDE was detected with good sensitivity and a limit of detection similar to that obtained with a commercial colorimetric test （0.018 ppb）, but with the advantage of using lower reagent volumes and a reduced analysis time. The use of microfluidic chips also provides improved linearity and a better reproducibility in comparison to those obtained with batch-based measurements using screen-printed electrodes. In order to design a detection system suitable for toxic compounds such as PBDEs, a reduced graphene oxide-PDMS composite was developed and optimized to obtain increased adsorption （based on both the hydrophobicity and rr-v~ stacking between rGO and PBDE molecules） compared to those of non-modified PDMS. To the best of our knowledge, this is the first demonstration of electrochemical detection of flame retardants and a novel application of the rGO-PDMS composite in a biosensing system. This system can be easily applied to detect any analyte using the appropriate immunoassay and it supports operation in complex matrices such as seawater.

关键词： electrochemistry microfluidics graphene oxide flame retardants lab on a chip polydimethylsiloxane

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Applications of biosensors for bacteria and virus detection in food and water–A systematic review

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Journal of Environmental Sciences 2022年第1期34卷 367-379页

作者： Zoi Kotsiri Jasmina Vidic Apostolos Vantarakis Environmental and Microbiology Unit Department of Public HealthMedical SchoolUniversity of Patras 26504Greece INRAE Agro Paris TechMicalis InstituteUniversity of Paris-Saclay78350 Jouy-en-JosasFrance

Biosensors for sensitive and specific detection of foodborne and waterborne pathogens are particularly valued for their portability,usability,relatively low cost,and real-time or near real-time *** application is widespread in several domains,including environmental *** main limitation of currently developed biosensors is a lack of sensitivity and specificity in complex *** to increased interest in biosensor development,we conducted a systematic review,complying with the PRISMA guidelines,covering the period from January 2010 to December *** review is focused on biosensor applications in the identification of foodborne and waterborne microorganisms based on research articles identified in the Pubmed,Science Direct,and Scopus search *** are still in progress to overcome detection limitations and to provide a rapid detection system which will safeguard water and food *** use of biosensors is an essential tool with applicability in the evaluation and monitoring of the environment and food,with great impact in public health.

关键词： Biosensor Bacteria Viruses Food Water lab on a chip

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On-chip 3D rotation of oocyte based on a vibration-induced local whirling flow

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Microsystems & Nanoengineering 2015年第1期1卷 150-158页

作者： Takeshi Hayakawa Shinya Sakuma Fumihito Arai Department of Micro-Nano Systems Engineering Nagoya UniversityNagoya-CityAichi-Pref.JAPAN

We propose a novel on-chip 3D cell rotation method based on a vibration-induced *** circular vibration is applied to a microchip with micropillar patterns,a highly localized whirling flow is induced around the *** direction and velocity of this flow can be controlled by changing the direction and amplitude of the applied ***,this flow can be induced on an open chip *** this study,we adopted a microchip with three micropillars arranged in a triangular configuration and an xyz piezoelectric actuator to apply the circular *** the centre of the micropillars,the interference of the vibration-induced flows originating from the individual micropillars induces rotational ***,a biological cell placed at this centre rotates under the influence of the *** three-plane circular vibrations in the xy,xz or yz plane,the cell can rotate in both the focal and vertical planes of the *** this 3D cell rotation method,we measured the rotational speeds of mouse oocytes in the focal and vertical planes as 63.7±4.0°s^(−1) and 3.5±2.1°s^(−1),***,we demonstrated the transportation and rotation of the mouse oocytes and re-positioned their nuclei into a position observable by microscope.

关键词： lab on a chip cell manipulation vibration-induced flow acoustic streaming

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Low-cost and versatile integration of microwire electrodes and optical waveguides into silicone elastomeric devices using modified xurographic methods

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Microsystems & Nanoengineering 2017年第1期3卷 107-113页

作者： Juncong Liu James B Mahony Ponnambalam Ravi Selvaganapathy Department of Mechanical Engineering McMaster UniversityHamiltonOntario L8S 4L7Canada Department of Pathology and Molecular Medicine McMaster UniversityHamiltonOntario L8S 4K1Canada School of Biomedical Engineering McMaster UniversityHamiltonOntario L8S4K1Canada

Microelectrodes are used in microfluidic devices for a variety of purposes such as heating,applying electric fields,and electrochemical ***,they are still manufactured by expensive deposition techniques such as sputtering or evaporation and patterned using photolithography *** recently,alternate methods including nanoparticle sintering and use of liquid metal flowing through microchannels have been used to fabricate *** methods are limited in the material choices or require post processing to be integrated into *** we developed a low-cost and versatile method to integrate high-quality metal microwires into polydimethylsiloxane(PDMS)using *** microwire integration process includes cutting slit pattern on PDMS substrate and subsequent writing metal microwires into the slit pattern using a specialized *** the microwire-integrated PDMS was sealed/bonded using uncured PDMS *** method enables integration of metal microwires of diameter as small as 15μm into PDMS *** of multiple microwires with minimum spacing of 150μm has also been *** versatility of this method is demonstrated by the fabrication of metal microwire suspended in the middle of the microchannel,which is difficult to achieve using conventional electrode fabrication *** low-cost method avoids expensive clean room fabrication yet producing high-quality electrodes and can be used in a variety of microfluidic and MEMS applications.

关键词： lab on a chip microelectrode polydimethylsiloxane(PDMS) xurography

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Nanotechnology:fundamental research to product development

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Engineering Sciences 2012年第5期10卷 42-44页

作者： Graham J Davie Zahra F Rad Carl Anthony Philip Prewett Jing Peng Robert Nordon The University of New South Wales Sydney NSW 2025 Australi The University of Birmingham Birmingham B15 2TT UK Harbin Institute of Technology Harbin 150001 China

The concept of an integrated "lab on a chip" has long been a goal for the micro-electro-mechanical-systems(MEMS) *** would entail the integration of not only the sampling and analysis of various functions,but also the ability to transmit this information off the chip to a central *** paper describes the initial steps in the fabrication of a "lab on a chip" which would continually analyze blood sampled via microneedles using techniques such as nano plasmonics,specifically,concentrations of *** analysis could then be transmitted off the chip using digital signal *** paper describes the analysis and optimization of the microneedle shape and size and the fabrication of the resulting needles in silicon using deep reactive ion etching(DRIE).The paper also describes the opportunities for fabrication of such needles in alternative materials and describes the issues that still have to be overcome before such an integrated device is realized.

关键词： MEMS micro-needles lab on a chip nanotechnology

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