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Acute toxicity study of Aspidopterys obcordata aqueous extract in Sprague-Dawley rats

Journal of Traditional Chinese Medicine 2016年第3期36卷 377-381页

作者： Li Yihang Li Guang Song Meifang Li Xuelan Zhan Xia Lu Juan Chen Xi Research Center for Pharmacology Yunnan Branch Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Jinghong 666100 China Key Laboratory of Dai and Southern Medicine of Xishuangbanna Dai Autonomous Prefecture Jinghong 666100 China School of Food and Chemical Engineering Beijing Technology and Business University Beijing 100048China Research Center for Pharmacology and Toxicology Institute of Medicinal Plant Development Chinese Academyof Medical Sciences Peking Union Medical College Beijing 100094 China

OBJECTIVE: To examine the acute toxicity of an aqueous extract of Aspidopterys obcordata(A. obcordata) in Sprague Dawley ***: The rats were orally administered a dose of 5000 mg/kg body weight and observed continuously for 6 h and then daily for 14 days. Control rats were administered distilled water. The effect of the extract on general behavior, body weight, and food and water intake were *** 14 days, the rats were sacrificed and their organs(liver, heart, spleen, lungs, kidney, adrenal glands, ovaries, and testes) were removed for macroscopic examination. The body and organ weights in addition to hematology(e.g., hemoglobin and white blood cell counts) and clinical blood biochemistry(e.g., albumin and bilirubin) were also ***: There were no deaths recorded, and the rats treated with A. obcordata showed no signs of toxicity. All measured parameters in rats treated with A. obcordata were unaffected when compared with those in control rats. The acute toxicity(LD_(50))was estimated to be > 5000 mg/kg body ***: Our results demonstrate the safety of an acute oral administration of an aqueous extract of A. obcordata in rats and indicate that future subacute and long-term toxicity testing of A. obcordata is warranted.

关键词： Aspidopterys obcordata Dai medicine Toxicity tests acute kidney calculi

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Bidirectional associations among gallstone disease,non-alcoholic fatty liver disease,kidney stone disease

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World Journal of Gastroenterology 2024年第46期30卷 4914-4928页

作者： Guo-Heng Jiang Sheng Li Hong-Yu Li Lin-Jun Xie Shi-Yi Li Zi-Tong Yan Wen-Qian Yu Jing Luo Xuan Bai Ling-Xi Kong Yan-Mei Lou Chi Zhang Guang-Can Li Xue-Feng Shan Min Mao Xin Wang Department of Epidemiology and Biostatistics West China School of Public Health and West China Fourth HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Health Management Beijing Xiaotangshan HospitalBeijing 102211China Department of Prevention Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Pharmacy The People’s Hospital of Kaizhou DistrictChongqing 405400China Department of Pharmacy Bishan Hospital of Chongqing Medical UniversityChongqing 402760China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND A body of evidence has suggested bidirectional relationships among gallstone disease(GSD),non-alcoholic fatty liver disease(NAFLD),and kidney stone disease(KSD).However,the results are inconsistent,and studies on this topic in China are relatively *** goal is to explore the bidirectional associations among these three diseases through a multicenter study,systematic review,and *** To explore the bidirectional associations among these three diseases through a multicenter study,systematic review,and *** results may help to investigate the etiology of these diseases and shed light on the individualized prevention of these three *** Subjects who participated in physical examinations in Beijing,Tianjin,Chongqing in China were *** logistic regression was employed to explore the bidirectional relationships among GSD,KSD,and *** review and meta-analysis were initiated to confirm the epidemiologic evidence from previous observational ***,trial sequential analysis(TSA)was conducted to evaluate whether the evidence was sufficient and *** Significant bidirectional associations were detected among the three diseases,independent of potential confounding *** pooled results of the systematic review and meta-analysis also corroborated the aforementioned *** combined evidence from the multicenter study and meta-analysis was significant[pooled odds ratio(OR)=1.42,95%CI:1.16-1.75,KSD→GSD;pooled OR=1.48,95%CI:1.31-1.67,GSD→KSD;pooled OR=1.31,95%CI:1.17-1.47,GSD→NAFLD;pooled OR=1.37,95%CI:1.26-1.50,NAFLD→GSD;pooled OR=1.28,95%CI:1.08-1.51,NAFLD→KSD;pooled OR=1.21,95%CI:1.16-1.25,KSD→NAFLD].TSA indicated that the evidence was sufficient and *** The present study presents relatively sufficient evidence for the positive bidirectional associations among GSD,KSD,and *** results may provide clues for investigating the etiology of these t

关键词： Gallstones Non-alcoholic fatty liver disease kidney calculi Cross-sectional study Meta-analysis

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Insights from exploring the interrelated dynamics of gallstone disease,non-alcoholic fatty liver disease,and kidney stone disease

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World Journal of Gastroenterology 2024年第46期30卷 4977-4982页

作者： Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article delved into the comprehensive study by Jiang et al,which meticulously examined the bidirectional relationships among gallstone disease,nonalcoholic fatty liver disease,and kidney stone disease through a multicenter study,systematic review,and *** study provides significant evidence supporting these associations,offering valuable insights into the etiology and potential prevention strategies for these interconnected *** clinical significance of these bidirectional relationships is profound,as they underscore the importance of recognizing these conditions not only as isolated diseases but as part of a complex network that can influence each *** results highlight the critical need for thorough screening and personalized prevention strategies for individuals with these interconnected *** implications for prevention strategies and early screening practices are crucial,as they can lead to early detection and intervention,significantly altering disease progression and ***,identifying potential therapeutic targets within these shared pathways may enhance treatment efficacy and patient outcomes,making this research highly relevant to clinical *** comprehending the common pathophysiological mechanisms and applying specific interventions,healthcare professionals can greatly enhance patient care and lessen the impact of these widespread diseases on global health.

关键词： Gallstones Non-alcoholic fatty liver disease kidney calculi Cross-sectional study Multidisciplinary screening Chronic disease prevention Individualized prevention strategies Systemic inflammation Insulin resistance Shared pathophysiology

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Education and training evolution in urolithiasis:A perspective from European School of Urology

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Asian Journal of Urology 2023年第3期10卷 281-288页

作者： Vaki Antoniou Vineet Gauhar Panagiotis Kallidonis Andreas Skolarikos Domenico Veneziano Evangelo Liatsikos Bhaskar K.Somani University Hospital Southampton SouthamptonUK Department of Urology Ng Teng Fong General Hospital(NUHS)SingaporeSingapore Department of Urology University of PatrasGreece The Smith Institute for Urology Northwell HealthNew YorkUSA

Objective:With the worldwide increase in urolithiasis prevalence,the present study aimed to delineate and summarise recent evolutions in training for the management of ***:A PubMed search using the key words“simulation”,“training”,“ureteroscopy”,“RIRS”,“URS”,“percutaneous nephrolithotomy”,“PCNL”,“virtual reality”,“augmented reality”,“artificial intelligence”,“healthcare”,“curriculum”,and“assessment”was used to examine how education and training in urolithiasis have adapted over recent *** was placed on the role of high-and low-fidelity simulation models,virtual reality and artificial intelligence,and standardised assessment and ***:This review supports the necessity to incorporate technology,simulation,and other skill enhancement training modalities into surgical ***,these cannot solely replace mentored training with an experienced professional *** technological and simulation advancements are likely to prove increasingly important in urolithiasis training,it is just as important for stratification of robust curricula with validated *** also propose a pathway for future ***:Endourology subspeciality training programmes have successfully incorporated simulation model-based training for skill acquisition,refinement,and improving operative *** is achieved by maintaining a delicate balance between machine and in person mentor-based training.A trainee-centred model that follows the proposed curriculum could aid this balance for the future generation of trainees.

关键词： Ureteroscopy Laser kidney calculi Simulation Education Curriculum Artificial intelligence

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Bilateral hematoma after tubeless percutaneous nephrolithotomy for unilateral horseshoe kidney stones:A case report

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World Journal of Clinical Cases 2021年第31期9卷 9623-9628页

作者： Cheng Zhou Ze-Jun Yan Yue Cheng Jun-Hui Jiang Department of Urology Ningbo First HospitalNingbo Hospital of Zhejiang UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND Bilateral perirenal hematoma is rarely reported in endoscopic management of horseshoe kidney stones,and there are few studies reporting the formation of bilateral hematoma following tubeless percutaneous nephrolithotomy(PCNL)for unilateral horseshoe kidney *** SUMMARY A 32-year-old man was admitted to our hospital because of repeated intermittent hematuria for 10 *** abdominal computed tomography(CT)scan revealed calculi in the horseshoe kidney;the largest being 2 cm in *** PCNL was performed to remove the *** days after the operation,the patient was discharged in a stable *** days after discharge,the patient presented to our emergency department because of right low back pain and *** CT scan revealed subcapsular and perirenal hematocele and exudates in both ***-guided puncture and drainage of perirenal effusion were *** the temperature stabilized,the patient received low-pressure injection of urokinase 100000 U for 3 *** routine blood indexes and the renal function returned to normal in 3 *** re-examination 3 mo after lithotripsy showed that the subcapsular and perirenal hematoma and exudates in both kidneys were significantly absorbed as compared with those *** patient was followed up for 1 year,during which no flank pain or hematuria *** This is the first case report on the formation of bilateral hematoma following tubeless PCNL for unilateral horseshoe kidney calculi.

关键词： Horseshoe kidney kidney calculi Tubeless percutaneous nephrolithotomy Urokinase Case report

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Indications and contraindications for shock wave lithotripsy and how to improve outcomes

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Asian Journal of Urology 2018年第4期5卷 256-263页

作者： Luke F.Reynolds Tad Kroczak Kenneth T.Pace Division of Urology St.Michael’s HospitalTorontoCanada

For over 35 years shock wave lithotripsy has proven to be an effective,safe and truly minimally invasive option for the treatment of *** technical factors as well as patient selection can impact the success of the *** used published work focusing on outcomes of shock wave lithotripsy,risk of complications,and strategies for improving stone fragmentation to create this *** patient and technical factors have been found to impact success of *** to stone distance,stone density and composition,size and location of the stone within the urinary system all influence stone free rates.A slower rate with a gradual increasing voltage,precise targeting,proper coupling will improve stone fragmentation and decrease risk of *** selection of appropriate patients through a shared decision making process and attention to the technical factors that improve stone free rates is key to providing an effective treatment and patient satisfaction.

关键词： kidney calculi Nephrolithiasis Urolithiasis Extracorporeal shock wave therapy Lithotripsy

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Role of simulation in kidney stone disease:A systematic review of literature trends in the 26 years

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World Journal of Nephrology 2023年第4期12卷 104-111页

作者： Carlotta Nedbal Victoria Jahrreiss Clara Cerrato Amelia Pietropaolo Andrea Galosi Domenico Veneziano Panagiotis Kallidonis Bhaskar K Somani Department of Urology University Hospital Southampton NHS Foundation TrustSouthampton SO166YDUnited Kingdom Department of Urology Azienda Ospedaliero-Universitaria delle MarchePolytechnic University of MarcheAncona 60121Italy Department of Urology The Smith Institute for UrologyNorthwell HealthNew YorkNY 11042United States Department of Urology University of PatrasPatras 26500Greece

BACKGROUND Minimally invasive techniques for treatment of urinary stones requires expertise,experience and endoscopic *** provide a low-stress and low-risk environment while providing a realistic set-up and training *** To report the publication trend of‘simulation in urolithiasis’over the last 26 *** Research of all published papers on“Simulation in Urolithiasis”was performed through PubMed database over the last 26 years,from January 1997 to December *** were labelled and divided in three subgroups:(1)Training papers;(2)Clinical simulation application or surgical procedures;and(3)Diagnostic radiology *** subgroup was then divided into two 13-year time periods to compare and identify the contrast of different decades:period-1(1997-2009)and period-2(2010-2022).RESULTS A total of 168 articles published on the application of simulation in urolithiasis over the last 26 years(training:n=94,surgical procedures:n=66,and radiology:n=8).The overall number of papers published in simulation in urolithiasis was 35 in Period-1 and 129 in Period-2,an increase of+269%(P=0.0002).Each subgroup shows a growing trend of publications from Period-1 to Period-2:training papers+279%(P=0.001),surgical simulations+264%(P=0.0180)and radiological simulations+200%(P=0.2105).CONCLUSION In the last decades there has been a step up of papers regarding training protocols with the aid of various simulation devices,with simulators now a part of training *** the development of 3D-printed and high-fidelity models,simulation for surgical procedure planning and patients counseling is also a growing field and this trend will continue to rise in the next few years.

关键词： kidney calculi Urolithiasis Simulation Ureteroscopy Percutaneous nephrolithotomy Artificial intelligence

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Role of virtual reality in improving the spatial perception of the kidney during flexible ureteroscopy:A feasibility study using virtual reality simulators and 3D models

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Current Urology 2024年第1期18卷 24-29页

作者： Ali Talyshinskii Bm Zeeshan Hameed Ulanbek Zhanbyrbekuly Mesrur Selcuk Silay Nithesh Naik Milap Shah Anshuman Singh Bakhman Guliev Patrick Juliebø-Jones Bhaskar Kumar Somani Department of Urology Astana Medical UniversityAstanaKazakhstan Department of Urology Father Muller Medical CollegeMangaloreKarnatakaIndia Department of Urology Istanbul Medeniyet UniversityIstanbulTurkey Department of Mechanical and Industrial Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnatakaIndia Department of Urology Aarogyam Hospital AhmedabadIndia Department of Urology Kasturba Medical CollegeManipalManipal Academy of Higher EducationManipalKarnatakaIndia Department of Urology Maninsky HospitalSaint PetersburgRussia Department of Urology Haukeland University HospitalBergenNorway Department of Urology University Hospital Southampton NHS TrustSouthamptonUK

Background:The aims were to describe a software-based reconstruction of the patient-specific kidney cavity intraluminal appearance via a head-mounted device and to estimate its feasibility for training *** and methods:In total,15 novices were *** novice was shown a three-dimensional reconstruction of a patient's computed tomography scan,whose kidney was *** then joined the surgeon in the operating room and assisted them in detecting the stone during flexible ureteroscopy on the printed ***,each participant did a 7-day virtual reality(VR)study followed by virtual navigation of the printed kidney model and came to the operating room to help the surgeon with ureteroscope *** length of the procedure and the number of attempts to find the targeted calyx were ***:With VR training,the length of the procedure(p=0.0001)and the number of small calyces that were incorrectly identified as containing stones were significantly reduced(p=0.0001).All the novices become highly motivated to improve their endourological skills *** noticed minimal values for nausea and for ***,oculomotor-related side effects were defined as *** specialists noticed a good similarity between the VR kidney cavity representation and the real picture,strengthening the potential for the novice's education via VR ***:Virtual reality simulation allowed for improved spatial orientation within the kidney cavity by the novices and could be a valuable option for future endourological training and curricula.

关键词： Ureteroscopy kidney calculi Virtual reality Endourology Training Nephroscopy 3D

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Effects of lemon-tomato juice consumption on crystal formation in the urine of patients with calcium oxalate stones:A randomized crossover clinical trial

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Current Urology 2023年第1期17卷 25-29页

作者： Sathish K.Gopala Jim Joe Jithesh Chandran Department of Urology Government Medical College ThiruvananthapuramKerala686008India Department of Biochemistry Government Medical College KottayamKeralaIndia Department of General Surgery Government Medical College KonniKeralaIndia

Background:Dietary supplementation with citrate-containing juices may serve as an effective alternative to potassium citrate therapy for preventing calcium oxalate stone *** study was performed to evaluate whether consumption of lemon-tomato juice can decrease the tendency for stone formation in the urine of calcium oxalate stone *** and methods:The study was conducted as a prospective interventional randomized crossover clinical trial with a repeated-measures ***-two patients with calcium oxalate stones and no metabolic abnormalities in the urine treated with lithotripsy at a tertiary care center from August 2017 to July 2018 were *** a 14-hour overnight fasting,urine samples were collected after the patients consumed either milk only or milk and lemon-tomato *** urine was tested for multiple parameters,including urine pH,specific gravity,calcium-creatinine ratio,and supersaturation with sodium oxalate,followed by optical density measurement via ***:There were no significant differences in the background characteristics between the 2 *** optical density of the urine samples obtained after consumption of milk only was significantly higher than that after consumption of milk and lemon-tomato juice(mean=0.131 for milk only vs.0.053 for milk and lemon-tomato juice,p<0.001).The urine calcium-creatinine ratio was similar between the groups(mean=0.141 for milk only vs.0.076 for milk and lemon-tomato juice,p=0.019).Conclusions:The addition of lemon-tomato juice as a source of citrate in the diet significantly decreases the established risk factors for calcium oxalate stone formation in *** study was prospectively registered at CTRI under number CTRI/2017/04/008312 on April 7,2017.

关键词： Calcium oxalate Dietary supplements Fruit and vegetable juices kidney calculi Urolithiasis

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Advances in percutaneous stone surgery

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Asian Journal of Urology 2015年第1期2卷 26-32页

作者： Christopher Hartman Nikhil Gupta David Leavitt David Hoenig Zeph Okeke Arthur Smith Hofstra North Shore-LIJ School of Medicine The Arthur Smith Institute for UrologyNew Hyde ParkNYUSA

Treatment of large renal stones has changed considerably in recent *** increasing prevalence of nephrolithiasis has mandated that urologists perform more surgeries for large renal calculi than before,and this has been met with improvements in percutaneous stone *** this review paper,we examine recent developments in percutaneous stone surgery,including advances in diagnosis and preoperative planning,renal access,patient position,tract dilation,nephroscopes,lithotripsy,exit strategies,and post-operative antibiotic prophylaxis.

关键词： Nephrolithiasis kidney calculi Percutaneous nephrolithotomy

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