Effects of lemon-tomato juice consumption on crystal formation in the urine of patients with calcium oxalate stones:A randomized crossover clinical trial
作者机构：Department of UrologyGovernment Medical College ThiruvananthapuramKerala686008India Department of BiochemistryGovernment Medical College KottayamKeralaIndia Department of General SurgeryGovernment Medical College KonniKeralaIndia
出 版 物：《Current Urology》 (当代泌尿学（英文）)
年 卷 期：2023年第17卷第1期
页 面：25-29页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 070301[理学-无机化学]
基 金：grant from the State Board for Medical Research Government Medical College Thiruvananthapuram Kerala India a government funding agency under grant number A2/SBMR(2016-2017)/27717/2016/MCT
主 题：Calcium oxalate Dietary supplements Fruit and vegetable juices Kidney calculi Urolithiasis
摘 要：Background:Dietary supplementation with citrate-containing juices may serve as an effective alternative to potassium citrate therapy for preventing calcium oxalate stone *** study was performed to evaluate whether consumption of lemon-tomato juice can decrease the tendency for stone formation in the urine of calcium oxalate stone *** and methods:The study was conducted as a prospective interventional randomized crossover clinical trial with a repeated-measures ***-two patients with calcium oxalate stones and no metabolic abnormalities in the urine treated with lithotripsy at a tertiary care center from August 2017 to July 2018 were *** a 14-hour overnight fasting,urine samples were collected after the patients consumed either milk only or milk and lemon-tomato *** urine was tested for multiple parameters,including urine pH,specific gravity,calcium-creatinine ratio,and supersaturation with sodium oxalate,followed by optical density measurement via ***:There were no significant differences in the background characteristics between the 2 *** optical density of the urine samples obtained after consumption of milk only was significantly higher than that after consumption of milk and lemon-tomato juice(mean=0.131 for milk only vs.0.053 for milk and lemon-tomato juice,p0.001).The urine calcium-creatinine ratio was similar between the groups(mean=0.141 for milk only vs.0.076 for milk and lemon-tomato juice,p=0.019).Conclusions:The addition of lemon-tomato juice as a source of citrate in the diet significantly decreases the established risk factors for calcium oxalate stone formation in *** study was prospectively registered at CTRI under number CTRI/2017/04/008312 on April 7,2017.
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