检索结果-南通市图书馆

Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第8期18卷 899-901页

作者： Chang Qing Shi Zhang Qin Liu Wen Qing Lin Yuan Wei Chen Key Laboratory of Asymmetric Synthesis ＆ Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

A variety of indole derivatives were designed, synthesized and preliminarily evaluated for their in vitro cytotoxic activity in the A431 and H460 cell lines. All the compounds examined conferred unusual potency in a tumor cell cytotoxicity assay. The findings showed the indole derivatives would be a promising candidate for the development of new anticancer agents.

关键词： indoles Synthesis Kinesin spindle protein inhibitor Cytotoxicity Cancer treatment

HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones from indoles and isatins

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2020年第9期31卷 2465-2468页

作者： Xiaohan Yuan Shuai Wang Jialing Cheng Bin Yu Hong-Min Liu School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Gordon Center for Medical Imaging Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02129United States State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

The first HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones(27 examples,up to 98% yield) from readily available indoles and isatin derivatives are *** protocol shows well tolerance of different functional groups and features mild reaction conditions such as short reaction time(~1 h),no usage of catalyst,easy operation and product *** particular intere st is the formation of two C-C bonds and one all-carbon quaternary *** protocol could serve as an alternative strategy to synthesize biologically important 3,3-di(indolyl)indolin-2-ones for biological testing.

关键词： indoles Isatins HFIP Catalyst-free synthesis 3,3-Di(indoly)indolin-2-ones

Conjugate Addition of indoles to α, β-Unsaturated Ketones （Chalcones） Catalyzed by KHSO4 under Ultrasonic Conditions

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2007年第12期25卷 1777-1780页

作者：曾晓飞纪顺俊沈舒苏 Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical Engineering Suzhou University Suzhou Jiangsu 215123 China

Conjugate addition of indoles to a variety of α,β-unsaturated ketones （chalcones） mediated by a catalytic amount of KHSO4 at room temperature under ultrasonic conditions to afford the corresponding Michael adducts... 详细信息

关键词： KHSO4 indoles α,β-unsaturated ketones conjugate addition reaction

A convenient one-pot three component synthesis of 3-aminoalkylated indoles catalyzed by 3-chlorophenylboronic acid

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2013年第5期24卷 422-424页

作者： Santosh V.Goswami Prashant.B.Thorat Vijay N.Kadam Sachin A.Khiste Sudhakar R.Bhusare Department of Chemistry Dnyanopasak College

An efficient protocol was developed for the synthesis of 3-aminoalkylated indoles using 3- chlorophenylboronic acid as a catalyst under ambient temperature *** three-component reaction of indoles,aromatic aldehydes and N-methyl aniline offered corresponding 3-aminoalkylated indoles in excellent *** protocol presents some remarkable features such as mild reaction conditions,simple workup procedure and excellent yields.

关键词： 3-Aminoalkylaed indoles 3-Chlorophenylboronic acid Aromatic aldehyde N-Methylaniline indoles

Catalytic Thiourea Promoted Electrophilic Thiocyanation of indoles and Aromatic Amines with NCS/NH4SCN

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2016年第11期34卷 1081-1085页

作者： Cancan Wang Zhonghao Wang Liang Wang Qun Chen Mingyang He School of Petrochemical Engineering Changzhou University Changzhou Jiangsu 213164 China

A simple and efficient protocol for the electrophilic thiocyanation of indoles and aromatic amines with thiourea/NCS/NH4SCN system has been developed. The major features of the present procedure are the mild conditions, good yields, short reaction times, and the use of inexpensive and readily available organocatalyst. Moreover, N-chlorosueeinimide （NCS） was found to be indispensable, and thiourea could greatly promote the reaction.

关键词： thiocyanation indoles aromatic amines catalytic thiourea N-chlorosuccinimide

Regioselective 2-alkylation of indoles withα-bromo esters catalyzed by Pd/P,P=O system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第1期33卷 197-200页

作者： Wei Tian Bowen Li Duanshuai Tian Wenjun Tang State Key Laboratory of Bio-Organic and Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesShanghai 200032China School of Chemistry and Material Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

A palladium-catalyzed 2-alkylation of indoles withα-bromo esters is developed by employing a P,P=O *** method features excellent regioselectivities,mild reaction conditions,and good functional group *** employment of the P,P=O ligand as well as 4 A molecular sieves were crucial for the success of the *** studies indicate the reaction proceed through a radical pathway.

关键词： Cross-coupling Alkylation indoles Palladium catalysis

Metal, iodine and oxidant-free electrosynthesis of substituted indoles from 1-(2-aminophenyl)alcohols

在线全文

学校读者我要写书评

暂无评论

Green Synthesis and Catalysis 2023年第4期4卷 311-315页

作者： Chengcheng Yuan Xiangxing Huang Yi Lu Zheng Fang Chengkou Liu Beining Chen Kai Guo College of Biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjing 211816China Department of Chemistry University of SheffieldSheffield S37HFUK State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech UniversityNanjing 211816China

A green and straightforward electrosynthesis of substituted indoles has been developed through dehydration and intramolecular dehydrogenative C–N bond-forming radical cross-coupling from 1-(2-aminophenyl)alcohols under metal,iodine and oxidant-free *** electrochemical indole synthesis strategy has an excellent functional group,water and air ***,a possible cyclization process was proposed based on the radicaltrapping,intermediate verification,cyclic voltammetry,EPR and control experiments.

关键词： Electrosynthesis Metal Iodine and oxidant-free C-N coupling indoles N-centered radicals

Reactivity of indoles through the Eyes of a Charge-Transfer Partitioning Analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

物理化学学报 2018年第6期34卷 692-698页

作者： OROZCO-VALENCIA Ulises GáZQUEZ José L. VELA Alberto Departamento de Quimica Centro de Investigacion y de Estudios Avanzados Av. Instituto Politecnico Nacional 2508 Colonia San Pedro Zacatenco Ciudad de Mexico 07360 Mexico. Departamento de Quimica Universidad Autonoma Metropolitana-Iztapalapa

A global and local charge transfer partitioning model,based on the cornerstone theory developed by Robert *** and Robert ***,which introduces two charge transfer channels(one for accepting electrons(electrophilic) and another for donating(nucleophilic)),is applied to the reaction of a set of indoles with 4,*** global analysis indicates that the prevalent electron transfer mechanism in the reaction is a nucleophilic one on the indoles,i.e.,the indoles under consideration transfer electrons to 4,*** the reactivity descriptorswith exchange-correlation functionals including exact exchange(global hybrids) yields slightly better correlations than those obtained with generalized gradient-approximated functionals;however,the trends are *** the trend obtained with the number of electrons donated by the indoles,and predicted by the partitioning model,with that observed experimentally based on the measured rate constants,we propose that the number of electrons transferred through this channel can be used as a nucleophilicity scale to order the reactivity of indoles towards 4,*** approach to obtain reactivity scales has the advantage of depending on the intrinsic properties of the two reacting species;therefore,it opens the possibility that the same group of molecules may show different reactivity trends depending on the species with which they are *** local model allows systematic incorporation of the reactive atoms based on the their decreasing condensed Fukui functions,and the correlations obtained by increasing the number of reactive atoms participating in the local analysis of the transferred nucleophilic charge improve,reaching an optimal correlation,which in the present case indicates keeping three atoms from the indoles and two from 4,*** atoms selected by this procedure provide valuable information about the local reactivity of the indoles.W

关键词： Chemical reactivity Conceptual DFT Charge transfer Nucleophilicity indoles Transition state prediction

Conjugate Addition of indoles to <i>α,β</i>-Unsaturated Ketones Using Bismuth (III) Bromide

在线全文

学校读者我要写书评

暂无评论

Green and Sustainable Chemistry 2019年第3期9卷 79-84页

作者： Tyler J. Rauwolf Zhijia Geng Zachary P. Kinney Jared L. Renfroe Jack H. Roireau Lauren T. Yep Ram S. Mohan Laboratory for Environmentally Friendly Organic Synthesis Department of Chemistry Illinois Wesleyan University Bloomington IL USA

An efficient method for the conjugate addition of indoles to a variety of chalcones using BiBr3 in ethanol (190 proof) is reported. Products are isolated by a simple procedure that avoids an aqueous work up and extensive chromatography, thus minimizing waste. Bismuth (III) compounds are especially attractive from a green chemistry perspective because they are remarkably nontoxic, non-corrosive and relatively inexpensive.

关键词： Bismuth Bismuth Bromide Conjugate Addition Green Chemistry indoles