Regioselective 2-alkylation of indoles withα-bromo esters catalyzed by Pd/P,P=O system

作     者：Wei Tian Bowen Li Duanshuai Tian Wenjun Tang Wei Tian;Bowen Li;Duanshuai Tian;Wenjun Tang

作者机构：State Key Laboratory of Bio-Organic and Natural Products ChemistryCenter for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesShanghai 200032China School of Chemistry and Material SciencesHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第1期

页      面：197-200页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000) CAS(No.QYZDY-SSW-SLH029) National Natural Science Foundation of China(Nos.21725205,21432007,21572246) STCSM-18520712200 K.C.Wong Education Foundation。 

主　　题：Cross-coupling Alkylation Indoles Palladium catalysis 

摘      要：A palladium-catalyzed 2-alkylation of indoles withα-bromo esters is developed by employing a P,P=O ligand.The method features excellent regioselectivities,mild reaction conditions,and good functional group compatibility.The employment of the P,P=O ligand as well as 4 A molecular sieves were crucial for the success of the transformation.Mechanistic studies indicate the reaction proceed through a radical pathway.