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Prevalence of HIV indeterminate Western Blot Tests and Follow-up of HIV Antibody Sero-Conversion in Southeastern China

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Virologica Sinica 2019年第4期34卷 358-366页

作者： Shouli Wu Min Gao Jian Zheng Pingping Yan Wei Wang Xiaoli Lu Yuefeng Qiu Yansheng Yan Fujian Provincial Center for Disease Control and Prevention Fuzhou 350001China Fujian Provincial Key Laboratory of Zoonosis Research Fuzhou 350001China School of Public Health Fujian Medical UniversityFuzhou 350004China Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou 350025China Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention Wuxi 214064China Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology Wuxi 214064China Jiangsu Institute of Parasitic Diseases Wuxi 214064China

HIV-indeterminate Western blotting(WB)results are typically obtained in WB confirmatory assays,and the number of indeterminate samples may increase with the detection of HIV infections,which will present considerable challenges for the management of HIV/*** acid detection has been used as a laboratory test for screening suspected or indeterminate ***,the effectiveness of these assays for the differential diagnosis of HIV-indeterminate WB samples remained *** this study,210 subjects with HIV-indeterminate WB results were detected from 6360 positive HIV screening samples between 2015 and 2016 in southeastern China,in which HIV-indeterminate WB results accounted for 3.30%.The highest proportion of indeterminate results was observed in pregnant and lying-in women receiving physical examinations(16.67%),followed by that in voluntary blood donors(8.82%).The most common WB band patterns were p24,gpl60 and p24,and *** follow-up study revealed that the highest negative and positive conversion rates of HIV antibodies were in samples with a single p24 band(80.28%),and with gpl60 and p24 bands(86.21%),*** the Env,Gag,and Pol antibodies,samples with a Gag band showed the highest negative conversion rate(81.25%),whereas the highest positive conversion rate was observed in samples with an Env band(56.76%).In addition,quantitative and qualitative HIV nucleic acid testing exhibited the highest sensitivity(96.3%)and specificity(97.85%),*** results indicate a lower proportion of HIV indeterminate WB results in southeastern China compared to previous reports,and the follow-up re-examination of patients with HIV indeterminate results should be *** acid testing facilitates the identification of HIV infections.

关键词： Human immunodeficiency virus(HIV) HIV indeterminate result Western blotting Nucleic acid test Differential diagnosis

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indeterminate pulmonary nodules in colorectal cancer

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World Journal of Gastroenterology 2015年第10期21卷 2967-2972页

作者： Eun-Joo Jung Su-Ran Kim Chun-Geun Ryu Jin Hee Paik Jeong Geun Yi Dae-Yong Hwang Department of Surgery Colorectal Cancer Center Konkuk University Medical Center Konkuk University School of Medicine Department of Radiology Konkuk University Medical Center Konkuk University School of Medicine

AIM:To investigate the clinicopathologic parameters of pulmonary metastasis in colorectal cancer(CRC) patients after lung operation of indeterminate pulmonary nodules(IPNs).METHODS:From a prospective database of CRCpatients,40 cases that underwent lung operation between November 2008 and December 2012 for suspicious metastatic pulmonary nodules on chest computed tomography(CT)were *** decision to perform a lung operation was made if the patient met the following criteria:(1)completely resected or resectable primary CRC;(2)completely resectable IPNs;(3)controlled or controllable extrapulmonary metastasis;and(4)adequate general condition and pulmonary function to tolerate pulmonary *** operation was performed by a thoracic surgeon without CT-guided biopsy for pathologic ***:A total of 40 cases of lung resection was performed in 29 *** patients underwent repeated lung *** final pathology result showed metastasis from the CRC in 30 cases(75%)and benign pathology in 10 cases(25%).The primary tumor site was the rectum in 26/30(86.6%)cases with pulmonary metastasis,but only 3/10(30%)cases in the benign group had a primary rectal cancer(P=0.001).Positron emission tomography(PET)-CT was performed for 22/30(73.4%)patients in the lung metastasis group and for 6/10(60.0%)patients in the benign ***-CT revealed hot uptake of18fluorine 2-fluoro-2-deoxy-D-glucose with all IPNs in both *** group with pulmonary metastasis had a higher incidence of primary rectal cancer(P=0.001),a more advanced tumor stage(P=0.011),and more frequent lymphatic invasion of tumor cells(P=0.005).Six cases with previous liver metastasectomy were present in the lung metastasis *** carcinoembryonic antigen levels before lung operation were not elevated in any of the ***:The stage and location of the primary tumor and tumor cell infiltration of lymphatics provide useful indicators for deciding on lung resection of IP

关键词： Colorectal neoplasm Lung neoplasm indeterminate pu

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Influence of the Interaction of the Mutant Inl Gene and the Type of Fruiting Branches ss on the Anatomical Features of the Stem in the indeterminate and Determinant Forms of G. hirsutumL.

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American Journal of Plant Sciences 2020年第4期11卷 538-548页

作者： Akmal A.Yuldashev Guljan M.Duschanova Miradkham F.Abzalov Gayrat N.Jurakulov Department of Ecology and Botany of Andijan State University AndijanUzbekistan Tashkent Botanical Garden Named after Acad.F.N.Rusanova at the Institute of Botany of the Academy of Sciences of the Republic of Uzbekistan TashkentUzbekistan Institute of Genetics and Experimental Plant Biology Academy of Sciences of the Republic of UzbekistanTashkentUzbekistan

For the first time, a comparative analysis of the structure of the apical meristem and the node of the main shoot of two forms of the indeterminate kind Namangan-77 and the determinant line of Determinant-2 and Determinant-3 of G. hirsutum in the kidney ding phase was carried out. In the apical meristem of the indeterminate form Namangan-77 is characterized by the recessive homozygous state of the mutant gene (inlinl) and the dominant homozygous, heterozygous state of the fruiting branch gene S-s: inlinlSS, inlinlSs, inlinlss—more pronounced vegetative, vegetative, with this, this form is predominated by the continuation of first-order shoots and the monopodial branching type with unlimited apical growth, accompanied by a uniform elongation of the internodes. In the apical meristem, in the forms of the determinant lines, Determinant-2 and Determinant-3 are characterized by the dominant homozygous state of the mutant gene (InlInl) and the recessive homozygous state of the allelic gene (ss)—InlInlss—there is a generative collateral kidney in the axillary leaf axial sinus, which is why these forms of the vegetative apex of the shoot when they transit to the reproductive state turn into a floral apical meristem and a sympodial branching type what happens through the development of inflorescences. Obviously, this is a consequence of a change in the phytohormonal status in the apical part of the stem as a result of the interaction of the mutant gene Inl and gene S. The node of the main stem in all forms was also studied, and a three-beam-three-lacuna type of structure was revealed, which is a fairly persistent characterizing feature of large taxa and can be used in their taxonomy.

关键词： Mutant Gene Allele Anatomy Stem indeterminate Determinant Monopodial Sympodial

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Least Squares Hermitian Problem of Matrix Equation (AXB, CXD) = (E, F) Associated with indeterminate Admittance Matrices

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Journal of Applied Mathematics and Physics 2018年第6期6卷 1199-1214页

作者： Yanfang Liang Shifang Yuan Yong Tian Mingzhao Li School of Mathematics and Computational Science Wuyi University Jiangmen China KaiQiao Middle School in KaiPing City Jiangmen China

For A∈CmΧn, if the sum of the elements in each row and the sum of the elements in each column are both equal to 0, then A is called an indeterminate admittance matrix. If A is an indeterminate admittance matrix and a Hermitian matrix, then A is called a Hermitian indeterminate admittance matrix. In this paper, we provide two methods to study the least squares Hermitian indeterminate admittance problem of complex matrix equation (AXB,CXD)=(E,F), and give the explicit expressions of least squares Hermitian indeterminate admittance solution with the least norm in each method. We mainly adopt the Moore-Penrose generalized inverse and Kronecker product in Method I and a matrix-vector product in Method II, respectively.

关键词： Matrix Equation Least Squares Solution Least Norm Solution Hermitian indeterminate Admittance Matrices

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Tumor-Associated Autoantibodies: Re-Optimization of EarlyCDT-Lung Diagnostic Performance and Its Application to indeterminate Pulmonary Nodules

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Journal of Cancer Therapy 2017年第5期8卷 506-517页

作者： Graham F. Healey Isabel K. Macdonald Chris Reynolds Jared Allen Andrea Murray Oncimmune Holdings plc Nottingham City Hospital Nottingham UK

Background: Low-dose computed tomography (CT) screening reduces lung cancer mortality but costs are prohibitive for most healthcare budgets due to high false positive rates. An adjunctive test able to distinguish malignant from benign pulmonary nodules would be hugely beneficial. EarlyCDT-Lung measures serum autoantibodies to tumor-associated antigens and has found clinical acceptance to aid early detection of lung cancer for high risk patients. However performance was optimized for screening. The construction of a receiver-operating characteristic (ROC) curve would enable optimization of performance for alternative settings, including nodule malignancy. Methods: A Monte-Carlo search method was used to construct a ROC curve using a case-control cohort, enabling high and low specificity versions of EarlyCDT-Lung to be determined. These were used for a theoretical evaluation of a nodule cohort, and positive predictive value (PPV) was calculated under the assumption of independence of risk source. Patients or their nodules are typically classified into three risk groups: low (0% - 10%), intermediate (10% - 65%) and high (>65%) risk of malignancy. The predicted shift in risk group by application of the high and low specificity versions, along with the current commercial EarlyCDT-Lung, was then estimated. Results: The ROC curve, with an area under the curve of 0.743, was constructed. The high specificity (98%), low specificity (49%) and current commercial (91% specificity) versions of EarlyCDT-Lung re-classified 27%, 23% and 26% of intermediate nodules, respectively, to either a higher (10%, 8% and 10%) or lower (17%, 15% and 16%) risk group. Conclusion: A ROC curve was constructed to allow performance prediction of EarlyCDT-Lung at different specificities in the indeterminate nodule setting. This enabled risk re-classification of intermediate risk nodules, and could therefore facilitate alternative more appropriate intervention. We have shown how a multivariate biomarke

关键词： Tumor-Associated Autoantibodies indeterminate Pulmonary Nodules Diagnostic Screening Computed Tomography ROC Curve

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IMPACT MODEL RESOLUTION ON PAINLEV'S PARADOX

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Acta Mechanica Sinica 2004年第6期20卷 649-660页

作者：赵振陈滨刘才山金海 Department of Mechanics and Engineering Science Peking UniversityBeijing 100871China

Painlevé's paradox is one of the basic difficulties for solving LCP of dynamic systems subjected to unilateral constraints.A bi-nonlinear parameterized impact model,consistent with dy- namic principles and experimental results,is established on the localized and quasi-static impact model *** simulations are carried out on the dynamic motion of Painlevé's *** re- sults confirm'impact without collision'in the inconsistent states of the system.A'critical normal force'which brings an important effect on the future movement of the system in the indeterminate states is *** the motion pattern for the impact process is obtained from numerical results, a rule of the velocity's jump that incorporates the tangential impact process is deduced by using an approximate impulse theory and the coefficient of restitution defined by *** results of the jump rule are quite precise if the system rigidity is big enough.

关键词： Painlevé's paradox inconsistent indeterminate impact without collision tangential impact

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Comparison of the use of wireless capsule endoscopy with magnetic resonance enterography in children with inflammatory bowel disease

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World Journal of Gastroenterology 2019年第28期25卷 3808-3822页

作者： Nadia Mazen Hijaz Thomas Mario Attard Jennifer Marie Colombo Neil Joseph Mardis Craig Alan Friesen Division of Gastroenterology Hepatology and Nutrition University of Missouri Kansas City Children’s Mercy Hospital Kansas City

BACKGROUND Magnetic resonance enterography (MRE) and wireless capsule endoscopy (WCE) are equally accepted modalities for noninvasive screening of small bowel involvement (SBI) in children with Crohn’s disease (CD) and indeterminate colitis (IC) albeit there is a paucity of data comparing the two and thereby guiding the clinician in selecting the ideal diagnostic approach. Therefore, the goal of this study is to provide additional evidence for capsule endoscopy role in the evaluation of established Crohn’s disease exacerbation compared to MRE in relation to Pediatric Crohn's Disease Activity Index (PCDAI), and histological indices. AIM To prospectively compare the findings of MRE and WCE and their agreement with PCDAI or histology in children with CD or IC. METHODS Consecutive patients diagnosed with CD and IC were screened for inclusion. After informed consent, patient’s demographic and clinical data was abstracted. The current pediatric disease activity index (PCDAI) and endoscopic findings were included. Patients underwent MRE and WCE including preprocedural patency capsule within a maximum of 7 d of each other. Pathological presence of active small bowel disease in ileal and duodenal biopsies were collected if the endoscopy was performed within 2 mo of the WCE study. Patients who failed to pass the PC were excluded from the study. WCE was read by two different experienced gastroenterologists (Attard TM and Colombo JM) blinded to each other's findings and to the findings on MRE (Mardis NJ). Agreement between WCE reviewers, WCE and MRE findings and concordance between positive PCDAI and SBI based on MRE compared with WCE was computed. RESULTS Forty-five patients were included in the study, 18 withdrew and 27 (20 males and 20 CD), mean age (standard deviation) 13.46 (2.4) years, completed the study protocol. There were no instances of capsule retention. Concordance between gastroenterologist reviewers was excellent for the diagnosis of small intestinal CD with good

关键词： Crohn’s disease Wireless capsule endoscopy Inflammatory bowel disease Magnetic resonance enterography Small bowel involvement Small bowel disease indeterminate colitis Pediatric Children

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Reaction Forces on a Fixed Ladder in Static Equilibrium: Analysis and Definitive Experimental Test of the Ladder Problem

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World Journal of Mechanics 2018年第9期8卷 311-342页

作者： M. P. Silverman Department of Physics Trinity College Hartford USA

The development of a theoretical model to predict the four equilibrium forces of reaction on a simple ladder of non-adjustable length leaning against a wall has long remained an unresolved matter. The difficulty is that the problem is statically indeterminate and therefore requires complementary information to obtain a unique solution. This paper reports 1) a comprehensive theoretical analysis of the three fundamental models based on treating the ladder as a single Euler-Bernoulli beam, and 2) a detailed experimental investigation of the forces of reaction as a function of applied load and location of load. In contrast to previous untested proposals that the solution to the ladder problem lay in the axial constraint on compression or the transverse constraint on flexure, the experimental outcome of the present work showed unambiguously that 1) the ladder could be modeled the best by a pinned support at the base (on the ground) and a roller support at the top (at the wall), and 2) the only complementary relation needed to resolve the static indeterminacy is the force of friction at the wall. Measurements were also made on the impact loading of a ladder by rapid ascent and descent of a climber. The results obtained were consistent with a simple dynamical model of the ladder as a linear elastic medium subject to a pulse perturbation. The solution to the ladder problem herein presented provides a basis for theoretical extension to other types of ladders. Of particular importance, given that accidents involving ladders in the workplace comprise a significant fraction of all industrial accidents, the theoretical relations reported here can help determine whether a collapsed structure, against which a ladder was applied, met regulatory safety limits or not.

关键词： Reaction Forces on a Ladder Reaction Forces on a Beam Impulse Load on a Ladder Ladder in Static Equilibrium Statically indeterminate Forces

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Cardiomyopathy protection in Chagas Disease

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World Journal of Cardiovascular Diseases 2013年第7期3卷 442-447页

作者： Jorge E. Mitelman Luisa Gimenez Instituto Centenario Buenos Aires Argentine Chagas Disease of the Inter-American Society of Cardiology Buenos Aires Argentine Department of Chagas the University Institute of Health Science Foundation H A Barcelo Buenos Aires Argentine Teodoro Alvarez Hospital Buenos Aires Argentine Cardiology in Northern Province of Buenos Aires Buenos Aires Argentine Chagas in the City of Buenos Aires Buenos Aires Argentine University Institute of Health Science Foundation H A Barcelo Buenos Aires Argentine

There is some published evidence suggesting micro vascular endothelial dysfunction and dysautonomia involvement in Chagas disease in association with cardiomyocyte changes favoring disease progression. The combined treatment between angiotensin converting enzyme (ACE) inhibitor drugs;Simvastatin, muscarinic antibody immunoadsorbent together with fungicidal drugs would open therapeutic possibilities in this disease.

关键词： Chagas Disease Chronic Period without Demonstrable Pathology Ex indeterminate Phase Endothelial Dysfunction Cardiac Dysautonomia Simvastatin ACE (Angiotensin Converting Enzyme) Inhibitor Muscarinic Antibody

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The Role of Friction in the Static Equilibrium of a Fixed Ladder: Theoretical Analysis and Experimental Test

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World Journal of Mechanics 2018年第12期8卷 445-463页

作者： M. P. Silverman Department of Physics Trinity College Hartford CT USA

In a recent publication the author derived and experimentally tested several theoretical models, distinguished by different boundary conditions at the contacts with horizontal and vertical supports, that predicted the forces of reaction on a fixed (i.e. inextensible) ladder. This problem is statically indeterminate since there are 4 forces of reaction and only 3 equations of static equilibrium. The model that predicted the empirical reactions correctly used a law of static friction to complement the equations of static equilibrium. The present paper examines in greater theoretical and experimental detail the role of friction in accounting for the forces of reaction on a fixed ladder. The reported measurements confirm that forces parallel and normal to the support at the top of the ladder are linearly proportional with a constant coefficient of friction irrespective of the magnitude or location of the load, as assumed in the theoretical model. However, measurements of forces parallel and normal to the support at the base of the ladder are linearly proportional with coefficients that depend sensitively on the location (although not the magnitude) of the load. This paper accounts quantitatively for the different effects of friction at the top and base of the ladder under conditions of usual use whereby friction at the vertical support alone is insufficient to keep the ladder from sliding. A theoretical model is also proposed for the unusual circumstance in which friction at the vertical support can keep the ladder from sliding.

关键词： Forces on a Ladder Static Equilibrium Law of Static Friction Statically indeterminate Forces of Reaction

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