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Acta Metallurgica Sinica(English Letters) 2013年第4期26卷 409-415页

作者： Ali Parsapour Saied Nouri Khorasani Mohammad Hossein Fathi Biomaterials Research Center Department of Chemical Engineering Isfahan University of Technology Department of Materials Engineering Isfahan University of Technology

The aim of this studies at simultaneous improvement of the corrosion behavior and biocompatibility of metallic implant and bone Osseointegration simultaneously. Stainless steel 316L （SS） was used as metallic substrate and after surface treatment with 15 vol.% sulfuric acid, it was coated with hydroxyapatite coating employing plasma - spraying process. Structure characterization techniques including XRD, SEM and EDX were also utilized to investigate the microstructure, morphology, and crystallinity of the coating. Electrochemical potentiodynamic tests were performed in two types of physiological solutions in order to determine and compare the corrosion resistance behavior of the coated and uncoated specimens as an indication of biocompatibility. The results indicate that the surface treatment and hydroxyapatite coating improve the corrosion resistance behavior of SS. The corrosion current density of the surface treated and the hydroxyapatite coated SS also decrease. These also show that surface treated and hydroxyapatite coated SS can be used as human body implants with the goals of corrosion resistance improvement （biocompatibility） and bone osseointegration.

关键词： Surface treatment hydroxyapatite coating Corrosion behavior Plasma spray Stainless steel 316L Human body implant

Biomimetic hydroxyapatite coating on the 3D-printed bioactive porous composite ceramic scaffolds promoted osteogenic differentiation via PI3K/AKT/mTOR signaling pathways and facilitated bone regeneration in vivo

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Journal of Materials Science & Technology 2023年第5期136卷 54-64页

作者： Bizhi Tan Naru Zhao Wei Guo Fangli Huang Hao Hu Yan Chen Jungang Li Zemin Ling Zhiyuan Zou Rongcheng Hu Chun Liu Tiansheng Zheng Gang Wang Xiao Liu Yingjun Wang Xuenong Zou Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology Department of Spine SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641China National Engineering Research Center for Tissue Restoration and Reconstruction Guangdong Province Key Laboratory of Biomedical EngineeringSouth China University of TechnologyGuangzhou 510006China Department of Orthopedics The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China

The architecture and surface modifications have been regarded as effective methods to enhance the bi-ological response of biomaterials in bone tissue *** porous architecture of the implanta-tion was essential conditions for bone ***,the design of biomimetic hydroxyap-atite(HAp)coating on porous scaffolds was demonstrated to strengthen the bioactivity and stimulate ***,bioactive bio-ceramics such asβ-tricalcium phosphate(β-TCP)and calcium sili-cate(CS)with superior apatite-forming ability were reported to present better osteogenic activity than that of *** in this study,3D-printed interconnected porous bioactive ceramicsβ-TCP/CS scaf-fold was fabricated and the biomimetic HAp apatite coating were constructed in situ via hydrothermal reaction,and the effects of HAp apatite layer on the fate of mouse bone mesenchymal stem cells(mBM-SCs)and the potential mechanisms were *** results indicated that HAp apatite coating en-hanced cell proliferation,alkaline phosphatase(ALP)activity,and osteogenic gene ***-more,PI3K/AKT/mTOR signaling pathway is proved to have an important impact on cellular *** present results demonstrated that the key molecules of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT)and mammalian target of rapamycin(mTOR)were activated after the biomimetic hydrox-yapatite coating were constructed on the 3D-printed ceramic ***,the activated influence on the protein expression of Runx2 and BMP2 could be suppressed after the treatment of inhibitor *** vivo studies showed that the constructed HAp coating promoted bone formation and strengthen the bone *** results suggest that biomimetic HAp coating constructed on the 3D-printed bioac-tive composite scaffolds could strengthen the bioactivity and the obtained biomimetic multi-structured scaffolds might be a potential alternative bone graft for bone regeneration.

关键词： Bioactive ceramics hydroxyapatite coating 3D-printed porous ceramic scaffold PI3K/AKT/mTOR signaling pathway Bone regeneration

Preparation and properties of a cerium-containing hydroxyapatite coating on commercially pure titanium by micro-arc oxidation

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Rare Metals 2008年第3期27卷 257-260页

作者： HUANG Yong WANG Yingjun NING Chengyun NAN Kaihui HAN Yong College of Materials Science and Engineering South China University of Technology Guangzhou 510641 China Key Laboratory of SpeciaUy Functional Materials Ministry of Education of China Guangzhou 510640 China State Key Laboratory for Mechanical Behavior of Materials Xi＇an Jiaotong University Xi ＇an 710049 China

A porous cerium-containing hydroxyapatite coating on commercially pure titanium was prepared by micro-arc oxidation （MAO） in an electrolytic solution containing calcium acetate, p-glycerol phosphate disodium salt pentahydrate （β-GP）, and cerium nitrate. The thickness, phase, composition morphology, and biocompatibility of the oxide coating were characterized by X-ray diffraction （XRD）, electron probe microanalysis （EPMA）, scanning electron microscopy （SEM） with energy dispersive X-ray spectrometer （EDS）, and cell culture. The thickness of the MAO film is about 15-25 ~tm, and the coating is porous and uneven, without any apparent interface to the titanium substrates. The results of XRD and EDS show that the porous coating is made up of hydroxyapatite （HA） film containing Ce. The favorable osteoblast cell affinity makes the Ce-HA film have a good biocompatibility. The Ce-HA film is expected to have significant medical applications as dental implants and artificial bone joints.

关键词： surface cerium hydroxyapatite coating micro-arc oxidation titanium porosity

Hydrothermal synthesis of hydroxyapatite coating on the surface of medical magnesium alloy and its corrosion resistance

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Progress in Natural Science:Materials International 2021年第2期31卷 324-333页

作者： Shifeng Wen Xianglei Liu Jiahui Ding Yulai Liu Ziting Lan Zimeng Zhang Guangmeng Chen School of Mechanics and Civil & Architecture Northwestern Polytechnical University

The early corrosion control of biomedical magnesium alloy is an important measure to determine its good performance during implantation into human body. The deposition of calcium phosphate biological coating is the most effective solution at present. In this paper, hydroxyapatite（HAP） coating was hydrothermal synthesized on the surface of AZ31 B magnesium alloy, and the influence mechanism of hydrothermal synthesis temperature, time and solution concentration was investigated. The synthesis conditions and deposition mechanism of hydroxyapatite coating without DCPA（CaHPO4） were proposed. The surface morphology of the coating was observed by field emission electron scanning microscope（FESEM）. The types and contents of microelements in the material were analyzed by energy disperse spectroscopy（EDS）. Fourier transform infrared spectroscopy（FTIR） was used to analyze the functional group information of the coating surface. The corrosion resistance of different experimental groups was studied by electrochemical test. The results showed that when the calcium phosphate solution concentration was 0.1 mol/L and the calcium/phosphorus ratio was 1.67, the coating had better morphology structure and corrosion resistance, and the calcium/phosphorus ratio of HAP crystals reached 1.58, the epit of the prepared AZ31 B-HAP coating by bare metal increased from -1.51 V to -1.18 V, the impedance value reached 1.0×10～5Ω·cm2, and the early corrosion of magnesium alloy substrate was effectively delayed.

关键词： Medical magnesium alloy hydroxyapatite coating Corrosion property Electrochemistry

Influence of Zirconia on hydroxyapatite coating on Ti-Alloy by Laser Cladding

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Transactions of Tianjin University 2003年第4期9卷 292-295页

作者：杜海燕霍伟荣高海王丽娟邱世鹏刘家臣 Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education

coating titanium alloy with the bioceramic material hydroxyapatite(HAP) has been used to improve the poor osteoinductive properties of pure titanium alloy. But in clinical applications, the mechanical failure of HAP-coated titanium alloy implant suffered at the interface of the HAP coatings and titanium alloy substrate will be a potential weakness in prosthesis. Yttria-stablized zirconia (YSZ) is expected to enhance the mechanical properties of the HAP coating and reduce the coefficient of thermal expansion difference between the coated layer and the substrate. These may reinforce the bonding strength between the coatings and the substrate. In this paper, HAP/YSZ composite coatings were cladded by laser. The effects of zirconia on the microstructure, mechanical properties and formation of tricalcium phosphate (TCP, Ca 3(PO 4) 2) of the HAP/YSZ composite coatings were evaluated. XRD, SEM and TEM were used to investigate the phase composition, microstructure and morphology of the coatings. The experimental results showed that adding YSZ in coatings was favorable to the composition and stability of HAP, and to the improvement of the adhesion strength, microhardness and microtoughness. A well uniform, crack-free coating of HAP/YSZ composites was formed on Ti-alloy substrate by laser cladding.

关键词： hydroxyapatite coating zirconia laser cladding titanium alloy

Study on the subsonic speed flame spraying coating of hydroxyapatite

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Rare Metals 2003年第2期22卷 116-120页

作者： MA Chen, LI Muqin, SHANG Dashan, and CHEN HongtaoKey Laboratory of Biomaterials, Jiamusi University, Heilongjiang Province, Jiamusi 154007, China (Received 2002-03-23) Jiamusi University Key Laboratory of Biomaterials 黑龙江 Jiamusi 154007

A new method of preparation of biomaterial composite coating by the techniqueof subsonic thermal spraying was discussed in this paper. Ti_6Al_4V and pure Ti were chosen assubstrate and sublayer material respectively and the working layer was sprayed with biomaterialhydroxyapatite (HAP), forming the composite coating. The experiments of heat shock and tensilestrength showed that the bonding strength between coating and substrate is almost as same as that ofspecimen in which Ni/Al powder was adopted as sublayer. The phases of TiN, TiO_2, and Ti_2O_3 wereformed in the sublayer, which are free of toxic and have no side effects. The powder of workinglayer HAP was decomposed partly during spraying, but it can be solved by later treatment.

关键词： metal matrix composites bio-ceramics subsonic speed flame spraying hydroxyapatite coating

hydroxyapatite coatings on Titanium Prepared by Electrodeposition in a Modified Simulated Body Fluid

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Chinese Journal of Chemical Engineering 2009年第4期17卷 667-671页

作者：赵旭辉杨灵芳左禹熊金平 School of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China

hydroxyapatite coatings were directly prepared on anodized titanium by electro-deposition method in a modified simulated body *** configuration,structure and bioactivity of the coating were investigated with scanning electron microscopy(SEM),X-ray diffraction analyzer(XRD)and Fourier transform infrared spectros-copy(FTIR)*** results demonstrated that pure and homogeneous hydroxyapatite coating can be obtained without any *** prepared coating showed good bioactivity in simulated body fluid(SBF).The time required for a fully covered dense hydroxyapatite coatings was 4 days immersion in SBF.

关键词： hydroxyapatite coating electro-deposition modified simulated body fluid titanium anodization

Influence of Different Chelating Agents on Corrosion Performance of Microstructured hydroxyapatite coatings on AZ91D Magnesium Alloy

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Journal of Wuhan University of Technology(Materials Science) 2017年第1期32卷 179-185页

作者：赵丹丹孙瑞雪 CHEN Kezheng College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China

To improve the bioactivity and corrosion resistance of AZ91 D magnesium alloy,hydroxyapatite（HAp） coatings with novel microstructured morphologies were prepared successfully on AZ91 D substrates via a facile hydrothermal *** chelating agents including polyaspartic acid（PASP） and ethylenediaminetetraacetic acid（EDTA） were introduced to investigate their effects on the morphology and corrosion resistance of the coated magnesium *** results revealed that the coating prepared with PASP was composed of many uniform urchin-like microspheres,while the coating prepared with EDTA consisted of many flower-like ***,the crystallinity of the coating prepared with EDTA was much higher than that of the coating prepared with *** tests revealed that the corrosion resistance of the substrate was significantly improved after being coated with each *** test of the coated samples in simulated body fluid（SBF） demonstrated that the coatings could be biodegraded gradually and induce the formation of calcium phosphate particles.

关键词： magnesium alloy hydroxyapatite coating chelating agent corrosion resistance

Effects of zinc-substituted nano-hydroxyapatite coatings on bone integration with implant surfaces

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 518-525页

作者： Shi-fang ZHAO Wen-jing DONG Qiao-hong JIANG Fu-ming HE Xiao-xiang WANG Guo-li YANG Department of Oral Implantology Affiliated Stomatology HospitalSchool of MedicineZhejiang University

Objective:The purpose of this study was to investigate the effects of a zinc-substituted nano-hydroxyapatite(Zn-HA) coating,applied by an electrochemical process,on implant osseointegraton in a rabbit ***:A Zn-HA coating or an HA coating was deposited using an electrochemical *** morphology was examined using field-emission scanning electron *** crystal structure and chemical composition of the coatings were examined using an X-ray diffractometer(XRD) and Fourier transform infrared spectroscopy(FTIR).A total of 78 implants were inserted into femurs and tibias of *** two,four,and eight weeks,femurs and tibias were retrieved and prepared for histomorphometric evaluation and removal torque(RTQ) ***:Rod-like HA crystals appeared on both implant *** dimensions of the Zn-HA crystals seemed to be smaller than those of *** patterns showed that the peaks of both coatings matched well with standard HA *** spectra showed that both coatings consisted of HA *** Zn-HA coating significantly improved the bone area within all threads after four and eight weeks(Pcoating has potential for improving bone integration with an implant surface.

关键词： Zinc hydroxyapatite coating Electrochemical process Osseointegration Implant

hydroxyapatite Bioceramic coatings Prepared by Hydrothermal-electrochemical Deposition Method

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Journal of Wuhan University of Technology(Materials Science) 2014年第2期29卷 398-400页

作者：何代华 LIU Ping LIU Xinkuan CHEN Xiaohong MA Fengcang LI Wei ZHAO Caixia TU Jieyuan School of Materials Science & Engineering University of Shanghai for Science and Technology

The hydroxyapatite（HA） ceramic coating was successfully prepared on Ti6A14V alloy by the hydrothermal-electrochemical deposition method with constant voltage model. The phases of deposits were analyzed by X-ray diffraction. The releationship between crystallinity and depositing temperature was discussed. The microstructures of hydroxyapatite coating were observed by scanning electron microscope. The experimental results showed that the phases, crystaUinity and morphologies of deposits were influenced by depositing temperature （100℃, 120℃, 140℃, 160℃, 180℃ and 200℃, respectively）. The special hydrothermal environment can lower the crystallization temperature of HA. The crystallinity of HA increases firstly and then decreases with the increase of temperature. There is little hydroxyapatite deposited on the Ti6A14V surface when the depositing temperature is 100℃. The HA deposition increases with the increase of the depositing temperature. And the HA morphologies are influenced by the depositing temperature.

关键词： hydroxyapatite coating hydrotlaermal-electrochemieal depositing temperature crystallinity