检索结果-南通市图书馆

Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors

Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 48-55页

作者： Yeming Wang Li Guo Guohui Fan Yang Han Qiao Zhang Lili Ren Hui Zhang Geng Wang Xueyang Zhang Tingxuan Huang Weiyang Wang Lan Chen Lixue Huang Xiaoying Gu Xinming Wang Jingchuan Zhong Ying Wang Hui Li Jiapei Yu Zhibo Liu Chaolin Huang Bin Cao Jianwei Wang National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesChina-Japan Friendship HospitalBeijing 100029China National Health Commission Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 102629China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical SciencesBeijing 100029China School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeState Key Laboratory of Respiratory Health and MultimorbidityKey Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College)Ministry of EducationBeijing 100730China National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Clinical research and Data managementCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Jin Yin-tan Hospital WuhanHubei 430023China Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Rheumatology and Clinical Immunology Chinese Academy of Medical Sciences&Peking Union Medical CollegeNational Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID)Ministry of Science&TechnologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College Hospital(PUMCH)Key Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospsitalInstitute of Respiratory MedicineChinese

Background:The impact of corticosteroids on humoral responses in coronavirus disease 2019(COVID-19)sur-vivors during the acute phase and subsequent 6-month period remains *** study aimed to determine how the use of corticosteroids influences the initiation and duration of humoral responses in COVID-19 survivors 6 months after infection ***:We used kinetic antibody data from the lopinavir-ritonavir trial conducted at Jin Yin-Tan Hospital in January 2020,which involved adults hospitalized with severe COVID-19(LOTUS,ChiCTR2000029308).Anti-body samples were collected from 192 patients during hospitalization,and kinetic antibodies were monitored at all available time points after ***,plasma samples were collected from 101 COVID-19 survivors for comprehensive humoral immune measurement at the half-year follow-up *** main focus was comparing the humoral responses between patients treated with systemic corticosteroid therapy and the non-corticosteroid ***:From illness onset to day 30,the median antibody titre areas under the receiver operating characteristic curve(AUCs)of nucleoprotein(N),spike protein(S),and receptor-binding domain(RBD)immunoglobulin G(IgG)were significantly lower in the corticosteroids *** AUCs of N-,S-,and RBD-IgM as well as neutralizing antibodies(NAbs)were numerically lower in the corticosteroids group compared with the non-corticosteroid ***,peak titres of N,S,RBD-IgM and-IgG and NAbs were not influenced by *** 6-month follow-up,we observed a delayed decline for most binding antibodies,except N-IgM(𝛽−0.05,95%CI[−0.10,0.00])in the corticosteroids group,though not reaching statistical *** significant difference was observed for ***,for the half-year seropositive rate,corticosteroids significantly accelerated the decay of IgA and IgM but made no difference to N-,S-,and RBD-IgG or ***,corticosteroids group showed a trend towards d

关键词： COVID-19 Corticosteroid Immunity Antibody humoral response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

humoral response and Tolerance of Vaccination against SARS-CoV-2 in Adults Senegalese Patients Undergoing Hemodialysis: A Multicenter Prospective Study

引用

Open Journal of Nephrology 2024年第1期14卷 70-80页

作者： Lot Nehemie Motoula Latou Moustapha Mbow Modou Ndongo Gnagna Faye Gora Lo Sidy Mohamed Seck Department of Nephrology and Dialysis Military Hospital of Ouakam Dakar Senegal Immunology Laboratory Military Hospital of Ouakam Dakar Senegal Department of Nephrology and Dialysis Regional Hospital of Kedougou Kedougou Senegal Department of Nephrology Idrissa Pouye General Hospital Dakar Senegal Bacterioloy and Virology Laboratory CMIA Dakar Senegal IRL-3189 ESS/UGB/CNRS/UCAD/CNRST/USTB Faculty of Health Sciences University Gaston Berger Saint-Louis Senegal

Introduction: Following the COVID-19 pandemic, vaccination has been proposed in several countries as the main preventive measure despite very limited data, particularly in dialysis patients. We conducted this study to assess the immunological response to vaccination in Senegalese hemodialysis patients. Patients and Methods: We conducted a prospective study, in two dialysis centers in Dakar from March 30th to August 30th, 2021 including patients on hemodialysis for >6 months, vaccinated against SARS-CoV-2 according to the vaccination schedule recommended by WHO. A vaccine response was considered positive when seroconversion was observed after one dose of vaccine. The clinical efficacy of immunization was defined as the absence of new COVID-19 infection in patients who received a complete vaccination. Results: Among the 81 patients included in the study, 7.4% had anti-Spike IgM antibodies before their first vaccination. Seroprevalence of IgM antibodies was 38.3% one month after the first vaccine dose (at M1) and 8.6% one month after the second dose (at M4). Anti-Spike IgG antibodies were present in 40.3% of patients before vaccination, in 90.1% at M1, and in 59.7% at M4. Among patients previously infected with SARS-CoV-2, 10.2% had IgM antibodies at M0, 31.6% at M1, and 10.5% at M4 post-vaccination. Similarly, seroprevalences of IgG antibodies in this subgroup were 31.5%, 61.3%, and 50.0% respectively at M0, M1, and M4 post-vaccination. A comparison of seroconversion rates between M0 and M4 showed significant differences only for IgG in COVID-19 naive patients. Mean duration in dialysis and the existence of previous COVID-19 infection were associated with patients’ vaccinal response after the two doses. Age, gender and the use of immunosuppressive treatment did not influence post-vaccinal antibody production. Conclusion: Vaccination against COVID-19 in Senegalese hemodialysis patients induced a low seroconversion rate but it was well tolerated. M

关键词： SARS-Cov2 Vaccination humoral response Tolerance Hemodialysis Senegal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

humoral response to Toxoplasma gondii in Pregnant Women in Bangui Central African Republic

引用

Open Journal of Immunology 2022年第4期12卷 122-129页

作者： Wilfrid Sylvain Nambei Junior Ouefio Nguerenam Edwige Régina Kodia-Lenguetama Arsène Gbamonza Department of Science Biomedical Faculty of Health Science University of Bangui Bangui Central African Republic National Center of Blood Donor’s Ministry of Public Health Bangui Central African Republic Community Hospital of Bangui Bangui Central African Republic

Toxoplasmosis is a cosmopolitan antrhropozoonosis widespread in mammals and birds. Normally asymptomatic in the subject health, it can have serious consequences for the fetus in the first trimester of pregnancy in the pregnant woman. It is in this context that we propose to assess the immune response to T. gondii in pregnant women in Bangui. This was a retrospective analytical study that consulted the records of pregnant women received in prenatal consultations at the Bangui Community Hospital Maternity ward from January 2019 to December 2019. Socio-demographic and laboratory data (IgM, IgG response to T. gondii) and results of HIV serology were collected from January to June 2021. Chi2 test was used. A total of 307 pregnant women were analyzed. The average age of the women included was 28 (±6) years. The average parity of the entire sample was 2.18 (±1.93). Toxoplasmosis infectious was 14.65%. Women with a positive IgM response accounted for 17.58% and those with an IgG-positive response for 42.99%. Patients with a positive HIV were 5.86%. Patients aged 20 - 29 had a serological profile suggesting a probable ongoing infection (p = 0.010). The paucipares were more represented with no statistically significant difference (p = 0.23). Pregnant women were not significantly exposed to toxoplasmosis infectious (p = 0.96). Immunized and non-immunized subjects were similarly exposed [OR = 0.97;CI 95% 0.4 = 6 - 2.05]. Toxoplasmosis remains particularly serious during pregnancy. Seroprevalence was significantly higher in the 20 - 24 year age group. Women were similarly exposed depending on whether they were immunized or not. This requires the establishment of a specific prevention program against this disease.

关键词： T. gondii humoral response HIV Pregnant Women Central African Republic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Significant reduction of humoral response to SARS-CoV-2 4 months after the diagnosis of COVID-19

引用

Precision Clinical Medicine 2021年第1期4卷 73-76页

作者： Kang Zhang Zhen-Guo Ma Lei Yang Wei Kang Yun Yin Johnson Yiu-Nam Lau University Hospital and Faculty of Medicine Macao University of Science and TechnologyMacao SARChina Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060China Hubei Key Laboratory of Metabolic and Chronic Diseases Wuhan 430060China The First affiliated Hospital Sun Yat-Sen UniversityGuangzhou 510080China School of Business Macao University of Science and TechnologyMacao SARChina Department of Applied Biology and Chemical Technology Hong Kong Polytechnic UniversityHong Kong SARChina

Editor’s note A commentary on“humoral immune response to SARS-CoV-2 in Iceland”.humoral response to COVID-19 disease,including IgM and IgG antibodies against SARS-CoV-2 virus,is well documented.1,2 Neutralizing activities against SARS-CoV-2 virus have also been confirmed in patients who have recovered from COVID-19.2 These observations form the basis for the assumption that SARS-CoV-2 vaccines can be developed through stimulation of the host immune system to generate neutralizing antibodies to SARS-CoV-2 virus.

关键词： humoral response antibodies COVID-19 SARS-CoV-2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Temporal pattern of humoral immune response in mild cases of COVID-19

引用

World Journal of Biological Chemistry 2023年第2期14卷 40-51页

作者： Isadora Maria Pilati Campos Milena Marques Gabrielle Caroline Peiter Ana Paula Carneiro Brandalize Mauricio Bedim dos Santos Fabrício Freire de Melo Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Campus Anísio Teixeira Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND Understanding the humoral response pattern of coronavirus disease 2019(COVID-19)is one of the essential factors to better characterize the immune memory of patients,which allows understanding the temporality of reinfection,provides answers about the efficacy and durability of protection against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),and consequently helps in global public health and vaccination *** the patients who became infected with SARS-CoV-2,the majority who did not progress to death were those who developed the mild COVID-19,so understanding the pattern and temporality of the antibody response of these patients is certainly *** To investigate the temporal pattern of humoral response of specific immunoglobulin G(IgG)in mild cases of *** Blood samples from 191 COVID-19 real-time reverse transcriptase-polymerase chain reaction(RT-qPCR)-positive volunteers from the municipality of Toledo/Paraná/Brazil,underwent two distinct serological tests,enzyme-linked immunosorbent assay,and detection of anti-nucleocapsid *** samples and clinicoepidemiological data of the volunteers were collected between November 2020 and February *** assays were performed in duplicate and the manufacturers'recommendations were strictly *** data were statistically analyzed using multiple logistic regression;the variables were selected by applying the P<0.05 *** Serological tests to detect specific IgG were performed on serum samples from volunteers who were diagnosed as being positive by RT-qPCR for COVID-19 or had disease onset in the time interval from less than 1 mo to 7 *** time periods when the highest number of participants with detectable IgG was observed were 1,2 and 3 *** was observed that 9.42%of participants no longer had detectable IgG antibodies 1 mo only after being infected with SARS-CoV-2 and 1.57%were also IgG negative at less than 1 *** 5 mo,3.14%of volunteers were IgG n

关键词： humoral response Immunoglobulin G antibody Immune memory Mild cases COVID-19 SARS-CoV-2 infection Serological test

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune responses in Wild-type Mice Against Prion Proteins Induced Using a DNA Prime-Protein Boost Strategy

引用

Biomedical and Environmental Sciences 2011年第5期24卷 523-529页

作者： HAN YanLing LI Yuan SONG Juan WANG Ying SHI Qi CHEN Cao ZHANG BaoYun GUO Yan LI ChaoPing HAN Jun DONG XiaoPing State Key Laboratory for Infectious Disease Prevention and Control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Medical School Anhui University of Science and TechnologyHuainan 231001China

Objective To break immune tolerance to prion （PrP） proteins using DNA *** Four different human prion DNA vaccine candidates were constructed based on the pcDNA3.1 vector：PrP‐WT expressing wild‐type PrP,Ubiq‐PrP expressing PrP fused to ubiquitin,PrP‐LII expressing PrP fused to the lysosomal integral membrane protein type II lysosome‐targeting signal,and PrP‐ER expressing PrP locating the *** a prime‐boost strategy,three‐doses of DNA vaccine were injected intramuscularly into Balb/c mice,followed by two doses of PrP *** weeks after the last immunization,sera and spleens were collected and PrP‐specific humoral and cellular immune responses evaluated by ELISA and ELISPOT *** Higher levels of serum PrP antibodies were detected in mice vaccinated using the strategy of DNA priming followed by protein *** these,WT‐PrP,Ubiq‐PrP,and PrP‐LII induced significantly higher humoral *** tests showed markedly increased numbers of IFN‐γ‐secreting T cells in mice vaccinated using the strategy of DNA priming followed by protein boosting after stimulation with recombinant PrP23‐90 and PrP23‐***‐ER inducedthe strongest T‐cell *** Prion vaccines can break tolerance to PrP proteins and induce PrP‐specific humoral and cellular immune responses.

关键词： Prion DNA vaccine humoral response T‐cell response Prime‐boosting regime.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity

引用

Cellular & Molecular Immunology 2021年第2期18卷 318-327页

作者： Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto CIRI–Centre International de Recherche en Infectiologie Team EVIRUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Universitéde Lyon VetAgro SupMarcy-l’ÉtoileFrance Department of Infectious Agents and Hygiene University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Immunology University-Hospital of Saint-EtienneSaint-EtienneFrance CIRI–Centre International de Recherche en Infectiologie Team GIMAPUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Department of Infectious Diseases University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Occupational Medicine University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Intensive Care and Resuscitation(Réanimation G) University-Hospital of Saint-EtienneSaint-EtienneFrance Laboratoire Interuniversitaire de Biologie de la Motricité Universitéde LyonUniversitéJean MonnetSaint-EtienneFrance Department of Anesthesiology and Critical Care University-Hospital of Saint-EtienneSaint-EtienneFrance

Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for *** this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive *** show that nAb titers correlated strongly with disease severity and with anti-spike IgG ***,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low *** found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other ***,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against ***,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization ***,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted.

关键词： Antibody Pathogenesis humoral response COVID-19 SARS-CoV-2v

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Abnormal shift in B memory cell profile associated with Tfh cells during acute HIV-1 infection

Abnormal shift in B memory cell profile associated with Tfh ...

引用

第十三届全国免疫学学术大会

作者： Xiaofan Lu Xin Zhang Huan Xia Zhen Li Lifeng Liu Rui Wang Hao Wu Tong Zhang Li Liu Bin Su Beijing Key Laboratory for HIV/AIDS Research Center for Infectious Diseases Beijing You'an Hospital Capital Medical University AIDS Institute Research Center for Infection and Immunity Department of Microbiology Li Ka Shing Faculty of Medicine University of Hong Kong

Background: AIDS(acquired immunodeficiency syndrome) patients characteristically display systemic CD4 T-cell depletion and chronic immune activation, resulting in an ineffective cell-mediated and humoral response to HIV-1 *** between T follicular helper(Tfh) cells and germinal center B cells are essential for the differentiation and subsequent antibody responses of B ***, the extent to which HIV-1 infection affects the dynamic interplay between the two cell populations remains *** investigated the immunophenotypes of Tfh cells and B cells in individuals with acute and chronic HIV-1 ***: Study subjects used in this study were enrolled from the Beijing PRIMO clinical Cohort, a prospective study cohort of HIV-1-negative MSM to identify AHI at Beijing You’an hospital.26 acute HIV-1 infection(AHI) and 26 chronic HIV-1 infection(CHI) patients were recruited *** AHI individuals belonged were classified as having Fiebig stage Ⅲ-Ⅵ disease after the diagnosis of HIV-1 *** of the subjects studied received antiretroviral therapy at either the acute or chronic *** and functional characterization of Tfh-cell and B-cell subsets were analyzed by the multicolor flow ***: Our dissection of the changes in Tfh-cell and B-cell subsets in peripheral blood revealed a positive correlation between plasmablasts and Tfh cells in patients with acute and chronic HIV infection, whereas no correlation was found for other descendants of B cells in either set of ***: These findings have potential implications for the regulation of humoral homoeostasis during HIV-1 infection and may guide the design of efficient strategies for restoring immunity in HIV-infected patients.

关键词： B cells Tfh cells humoral response acute HIV-1 infection

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：