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Histological Assessment of Bone Regeneration in the Maxilla with homologous Bone Graft:A Feasible Option for Maxillary Bone Reconstruction

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Journal of Renewable Materials 2024年第1期12卷 131-148页

作者： Sergio Henrique Gonçalves Motta Ana Paula Ramos Soares Juliana Campos Hasse Fernandes Gustavo Vicentis Oliveira Fernandes Graduate Center of Faculdade Redentor CLIVORio de JaneiroBrazil Periodontics and Oral Medicine Department University of Michigan School of DentistryAnn ArborMI48109USA Centre for Interdisciplinary Research in Health(CIIS) Universidade Católica PortuguesaViseu3504-505Portugal

Bone biomaterials have been increasingly used to reconstruct maxillary atrophic ridges.Thus,the aim of this study was to evaluate bone reconstruction in the maxilla using a homologous cortico-cancellous FFB(lyophilized)graft and verify its reliability.Eight individuals were included from 2014 to 2018.The first surgery was performed to install homologous bone blocks in the maxilla.The period of the second intervention varied between 5 months and 15 days to 11 months(≈7.93 months).The biopsies were taken from the central region of the matured graft during the surgery for implant placement.All patients presented clinical and radiographic conditions for the installation of dental implants.There was a 100%of survival rate.The histological assessment showed that the homologous block bone graft was an osteoconductive biomaterial,with connective tissue present,and newly formed bone juxtaposed on its surface.There were bone trabeculae with osteocytes and active osteoblasts with connective tissue in the mineralization process;the remodeling process can be found through the reverse lines.A limited focus of necrosis with fibrosis was detected,with small resorption and areas of inflammatory infiltrate,but without clinical significance.The homologous block bone graft can be considered a feasible option to substitute the autogenous bone graft(gold standard),with predictable clinical and favorable histological results.The patients had a shorter surgical period,low morbidity,and an unlimited amount of biomaterial available at an accessible cost.

关键词： Regeneration bone graft histology homologous allogenous autogenous

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homologous gradient heterostructure-based artificial synapses for neuromorphic computation

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InfoMat 2023年第1期5卷 95-105页

作者： Changjiu Teng Qiangmin Yu Yujie Sun Baofu Ding Wenjun Chen Zehao Zhang Bilu Liu Hui-Ming Cheng Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen Institute and Institute of Materials ResearchShenzhen International Graduate SchoolTsinghua UniversityShenzhenPeople's Republic of China Faculty of Materials Science and Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of ScienceShenzhenPeople's Republic of China School of Electronic and Information Engineering Foshan UniversityFoshanPeople's Republic of China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyangPeople's Republic of China

Gradient heterostructure is one of fundamental interfaces and provides an effective platform to achieve gradually changed properties in mechanics,optics,and electronics.Among different types of heterostructures,the gradient one may provide multiple resistive states and immobilized conductive fila-ments,offering great prospect for fabricating memristors with both high neuromorphic computation capability and repeatability.Here,we invent a memristor based on a homologous gradient heterostructure(HGHS),compris-ing a conductive transition metal dichalcogenide and an insulating homolo-gous metal oxide.Memristor made of Ta–TaS_(x)O_(y)–TaS 2 HGHS exhibits continuous potentiation/depression behavior and repeatable forward/backward scanning in the read-voltage range,which are dominated by multi-ple resistive states and immobilized conductive filaments in HGHS,respec-tively.Moreover,the continuous potentiation/depression behavior makes the memristor serve as a synapse,featuring broad-frequency response(10^(-1)–10^(5) Hz,covering 106 frequency range)and multiple-mode learning(enhanced,depressed,and random-level modes)based on its natural and moti-vated forgetting behaviors.Such HGHS-based memristor also shows good unifor-mity for 5?7 device arrays.Our work paves a way to achieve high-performance integrated memristors for future artificial neuromorphic computation.

关键词： artificial synapses broad-frequency range gradient heterostructures homologous memristors neuromorphic computation

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Does the homologous booster with the inactivated coronavirus disease 2019 vaccine work for the omicron variant?Real-world evidence from Jilin,China

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Chinese Medical Journal 2023年第23期136卷 2892-2894页

作者： Jun Guo Lei Zha Kai Zeng Mingyu Shao Dan Chen Bing Wang Yun Zhou Gang Yang Xue Zhang Xia Zou Yan Zhang Yan Kang Department of Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610000China Intensive Care Unit Conch Hospital of Anhui Medical UniversityWuhuAnhui 241000China Institute of Infection and Global Health University of LiverpoolL697BELiverpoolUK Critical Care Unit The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150000China Hospital Administration Office Jilin Central General HospitalJilinJilin 132000China Medical Administration Department Jilin Central General HospitalJilinJilin 132000China Department of Cardiology Jilin Central General HospitalJilinJilin 132000China Department of Pulmonary and Critical Care Wuhu HospitalEast China Normal UniversityWuhuAnhui 241000China Department of Clinical Research Management West China HospitalSichuan UniversityChengduSichuan 610000China

To the Editor:The latest variant of concern,Omicron,has become the dominant global variant immediately after it was first reported in November 2021.[1]It contains>30 mutations in the spike protein,with 17 mutations in the receptor-binding domain,rendering it with increased transmissibility and capacity for immune evasion.[1,2]Moreover,the waning of protection has been observed over time since the coronavirus disease 2019(COVID-19)vaccination.[3]Therefore,a booster is highly recommended.A large-scale study in the UK assessing the effectiveness of the booster vaccination with either the BNT162b2 or mRNA-1273 indicated that the booster shot substantially increased protection against symptomatic infection in patients with the confirmed Omicron variant infection.[3]However,although the laboratory study has illustrated that the homologous booster with the inactivated COVID-19 vaccine could also yield potent neutralizing activity against the Omicron variant,[4]clinical evidence regarding the effectiveness of this vaccination program is limited.

关键词： vaccination homologous rendering

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Fibrillarin promotes homologous recombination repair by facilitating the recruitment of recombinase RAD51 to DNA damage sites

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第12期24卷 1165-1173页

作者： Yanhua MU Jinhua HAN Mingjie WU Zongfang LI Ke DU Yameng WEI Mengjie WU Jun HUANG National-Local Joint Engineering Research Center of Biodiagnosis&Biotherapy The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China The MOE Key Laboratory of Biosystems Homeostasis&Protection and Innovation Centerfor Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhou 310058China Zhejiang Provincial Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province Department of GeriatricsZhejiang Hospital.Hangzhou310030China Trauma Center The First Afiliated HospitalZhejiang University School of MedicineHangzhou 310003China The Afiliated Hospitalof Stomatology Schoolof StomatologyZhejiang University Schoolof MedicineKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhou 310006China Zhejiang Provincial Key Labratoryof Cancer Molecular Cell Biology Life Sciences InstituteZhejiang UniversityHangzhou 30058China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Eukaryotic organisms constantly face a wide range of internal and external factors that cause damage to their DNA.Failure to accurately and efficiently repair these DNA lesions can result in genomic instability and the development of tumors(Canela et al.,2017).Among the various forms of DNA damage,DNA doublestrand breaks(DSBs)are particularly harmful.Two major pathways,non-homologous end joining(NHEJ)and homologous recombination(HR),are primarily responsible for repairing DSBs(Katsuki et al.,2020;Li and Yuan,2021;Zhang and Gong,2021;Xiang et al.,2023).NHEJ is an error-prone repair mechanism that simply joins the broken ends together(Blunt et al.,1995;Hartley et al.,1995).

关键词： damage homologous

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Double versus single homologous intrauterine insemination for male factor infertility： a systematic review and meta-analysis

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Asian Journal of Andrology 2013年第4期15卷 533-538,I0010页

作者： Apostolos Zavos Alexandros Daoonte Antonios Garas Christina Verykouki Evangelos Papanikolao~ Georgios Anifandis Nikolaos P Polyzos Obstetrics and Gynecology University Hospital of Larissa Larissa 41110 Greece Aristotle University of Thessaloniki Assisted Reproduction Unit 1st OB-GYN Department Thessaloniki 56429 Greece and University Hospital Dutch-Speaking Free University of Brussels Brussels City 1090 Belgium

Male factor infertility affects 30%-50% of infertile couples worldwide, and there is an increasing interest in the optimal management of these patients. In studies comparing double and single intrauterine insemination （IUI）, a trend towards higher pregnancy rates in couples with male factor infertility was observed. Therefore, we set out to perform a meta-analysis to examine the superiority of double versus single IUI with the male partner＇s sperm in couples with male factor infertility. An odds ratio （OR） of 95% confidence intervals （CIs） was calculated for the pregnancy rate. Outcomes were analysed by using the ManteI-Haesel or DerSimonian-Laird model accordingto the heterogeneity of the results. Overall, five trials involving 1125 IUI cycles were included in the meta-analysis. There was a two-fold increase in pregnancies after a cycle with a double IUI compared with a cycle with a single IUI （OR. 2.0; 95% CI. 1.07-3.75; P〈O.03）. Nevertheless, this result was mainly attributed to the presence of a large trial that weighted as almost 50% in the overall analysis. Sensitivity analysis, excluding this large trial, revealed only a trend towards higher pregnancy rates among double IUI cycles （OR. 1.58; 95% CI. 0.59-4.21）, but without statistical significance （P=0.20）. Our systematic review highlights that the available evidence regarding the use of double IUI in couples with male factor infertility is fragmentary and weak. Although there may be a trend towards higher pregnancy rates when the number of IUIs per cycle is increased, further large and well-designed randomized trials are needed to provide solid evidence toide current clinical practice.

关键词： homologous intrauterine insemination male infertility meta-analysis systematic review

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miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis

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Chinese Journal of Cancer 2015年第11期34卷 485-487页

作者： Guoyan Liu Fengxia Xue Wei Zhang Department of Gynecology and Obstetrics Tianjin Medical University General Hospital Department of Pathology The University of Texas MD Anderson Cancer Center

Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem afecting prognosis. Our recent study established that micro RNA-506(mi R-506) expression was closely associated with progression-free survival and overall survival in two independent patient cohorts totaling 598 epithelial ovarian cancer cases. Further functional study demonstrated that mi R-506 could augment the response to cisplatin and olaparib through targeting RAD51 and suppressing homologous recombination in a panel of ovarian cancer cell lines. Systemic delivery of mi R-506 in an orthotopic ovarian cancer mouse model signiicantly augmented the cisplatin response, thus recapitulating the clinical observation. Therefore, mi R-506 plays a functionally important role in homologous recombination and has important therapeutic value for sensitizing cancer cells to chemotherapy, especially in chemo-resistant patients with attenuated expression of mi R-506.

关键词： MicroRNA-506, homologous recombination, Drug sensitivity, Synthetic lethality, RAD51

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Inhibition of KU70 and KU80 by CRISPR interference,not NgAgo interference,increases the efficiency of homologous recombination in pig fetal fibroblasts

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Journal of Integrative Agriculture 2019年第2期18卷 438-448页

作者： LI Guo-ling QUAN Rong WANG Hao-qiang RUAN Xiao-fang MO Jian-xin ZHONG Cui-li YANG Huaqiang LI Zi-cong GU Ting LIU De-wu WU Zhen-fang CAI Geng-yuan ZHANG Xian-wei National Engineering Research Center for Breeding Swine Industry College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642P.R.China Wens Foodstuff Group Co. Ltd.Yunfu 527400P.R.China

Non-homologous end-joining(NHEJ) is a predominant pathway for the repair of DNA double-strand breaks(DSB). It inhibits the efficiency of homologous recombination(HR) by competing for DSB targets. To improve the efficiency of HR, multiple CRISPR interference(CRISPRi) and Natronobacterium gregoryi Argonaute(NgAgo) interference(NgAgoi) systems have been designed for the knockdown of NHEJ key molecules, KU70, KU80, polynucleotide kinase/phosphatase(PNKP), DNA ligase IV(LIG4), and NHEJ1. Suppression of KU70 and KU80 by CRISPRi dramatically promoted(P0.05) HR efficiency. Interestingly, although the NgAgoi system significantly suppressed(P0.05) HR efficiency in primary fetal fibroblasts. Our result showed that both NgAgo and catalytically inactive Cas9(dCas9) could interfere with the expression of target genes, but the downstream factors appear to be more active following CRISPR-mediated interference than that of NgAgo.

关键词： homologous recombination non-homologous end-joining CRISPRi NgAgoi KU70 KU80

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Efficiency of olaparib in colorectal cancer patients with an alteration of the homologous repair protein

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World Journal of Gastroenterology 2016年第48期22卷 10680-10686页

作者： Francois Ghiringhelli Corentin Richard Sandy Chevrier Frédérique Végran Romain Boidot Department of Medical Oncology Center GF Leclerc21000 DijonFrance Platform of Transfer in Oncology Center GF Leclerc21000 DijonFrance INSERM UMR866 21000 DijonFrance University of Bourgogne Franche Comte 21000 DijonFrance

Precision medicine is defined by the administration of drugs based on the tumor's particular genetic characteristics. It is developing quickly in the field of cancer therapy. For example, KRAS, NRAS and BRAF genetic testing demonstrates its efficiency for precision medicine in colorectal cancer(CRC). Besides for these well-known mutations, the purpose of performing larger genetic testing in this pathology is unknown. Recent reports have shown that using the poly ADP ribose polymerase(PARP) inhibitor olaparib in patients with homologous repair enzyme deficiency gave positive clinical results in breast, ovarian and prostate cancers. We have reported here the cases of 2 patients with multi-treated metastatic CRC who underwent somatic and constitutional exome analyses. The analyses revealed a loss of function mutation in a homologous repair enzyme resulting in the loss of heterozygosity for both patients(Check2 for the first patient and RAD51 C for the second one). Both patients were treated with off-label usage of olaparib. While the first patient showed clinical benefit, reduction of carcinoembryonic antigen tumor marker and radiologic response, the second patient quickly presented a progression of the tumor. Additional genetic analyses revealed a frameshift truncating mutation of the TP53BP1 gene in the patient who progressed. Interestingly, deficiency in TP53BP1 was previously described to confer resistance to olaparib in mice breast cancer models. Our findings suggest that exome analysis may be a helpful tool to highlight targetable mutations in CRC and that olaparib may be efficient in patients with a homologous repair deficiency.

关键词： Colorectal cancer Exome analysis Genetic aberrations homologous repair deficiency Precision medicine

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Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination

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Cellular & Molecular Immunology 2021年第10期18卷 2455-2456页

作者： Swantje I.Hammerschmidt Berislav Bosnjak Günter Bernhardt Michaela Friedrichsen Inga Ravens Alexandra Dopfer-Jablonka Markus Hoffmann Stefan Pöhlmann Georg M.N.Behrens Reinhold Förster Institute of Immunology Hannover Medical SchoolHannoverGermany Department for Rheumatology and Immunology Hannover Medical SchoolHannoverGermany Infection Biology Unit German Primate Center-Leibniz Institute for Primate ResearchGöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenGöttingenGermany German Center for Infection Research(DZIF) Partner Site Hannover-BraunschweigHannoverGermany German Center for Lung Research(DZL) HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical SchoolHannoverGermany

Since the beginning of the COVID-19 pandemic,divergent variants of concern(VoCs)of SARS-CoV-2 have evolved and become the most prevalent SARS-CoV-2 variants in distinct locations at different times.Currently,the Delta variant(B.1.617.2)dominates infection events in large parts of the world.Immunization campaigns,however,still use SARS-CoV-2 vaccines based on the spike(S)protein of the original Wuhan virus.

关键词： Delta homologous campaign

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Efficient replacement of long DNA fragments via non-homologous end joining at norrcoding regions

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Journal of Molecular Cell Biology 2021年第1期13卷 75-77页

作者： Shanye Gu Jia Li Siyuan Li Jianbin Cao Jiwen Bu Yonggang Ren Wenjie Du Zhecong Chen Chufan Xu Mingcang Wang Lai Jiang Cheng Huang Jiulin Du Department of Anesthesiology and Surgical Intensive Care Unit Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Drug Discovery Laboratory School of PharmacyShanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyShanghai Research Center for Brain Science and Brain-Inspired IntelligenceChinese Academy of SciencesShanghai 200031China Department of Anesthesiology Affiliated Taizhou HospitalWenzhou Medical UniversityLinhai 317000China University of Chinese Academy of Sciences Beijing 100049China ShanghaiTech University Shanghai 200031China

Targeted double-strand breaks(DSBs)in genomes can be introduced efficiently by endonucleases(Umov et al.,2010;Jinek et al.,2012;Joung and Sander,2013),including zinc-finger nucleases,tran scription activator-like effector nu cleases,and clustered regularly in terspaced palindromic repeats(CRISPR)/Cas9.After DSBs,DNA repair is mainly via homology-directed repair(HDR)and/or non-homologous end joining(NHEJ)(Hustedt and Durocher,2016).It was reported that genomic DNA replacement can be achieved via HDR at the site of DSBs in multiple organisms(Dickinson et al.,2013;Yang et al.,2013;Zu et al.,2013),but the efficiency is still not enough for general application,in particular for replacing long DNA fragment that is more than hundreds of base pairs(bps).As NHEJ is 10-fold more active than HDR at DSB sites(Mao et al.,2008),we speculated that NHEJ can be utilized to implement long genomic DNA replacement with high efficiency.

关键词： DNA joining homologous

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