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Responses of serum inflammatory factor high-sensitivity c-reactive protein, interleukin-6, and tumor necrosis factor-alpha in elderly males with cerebral infarction Non-randomized concurrent control

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Neural Regeneration Research 2008年第5期3卷 498-500页

作者： Guiping Jiao Xinjie Tan Zhiliu Yuan chunling Li Jing Wang Wen Mo Department of Medicine for cadre the People＇s Hospital of Guizhou Province Guiyang 550002 Guizhou Province China

BAcKGROUND： cerebral infarction is poorly treated due to neuronal necrosis and secondary pathophysiological changes; for example, free radical production and inflammatory reactions. OBJEcTIVE： To detect the levels of high-sensitivity c-reactive protein （hs-cRP）, interleukin-6 （IL-6）, and tumor necrosis factor- a （TNF- α ） in elderly males with cerebral infarction. DESIGN： Non-randomized current control study. SETTING： cadre Medical Department, Guizhou Provincial People＇s Hospital. PARTIcIPANTS： Forty elderly males （65-89 years old） with cerebral infarction were selected from cadre Medical Department, Guizhou Provincial People＇s Hospital from February 2004 to December 2006. All patients met the diagnostic criteria of cerebral infarction modified at the 4th National cerebrovascular Disease Academic Meeting, and were diagnosed on the basis of cT or MRI tests. Furthermore, 35 elderly male inpatients （65-87 years old） without cerebral infarction were selected as the control group. Included subjects provided confirmed consent and did not have heart disease, diabetes mellitus, lipid disorder, acute trauma, infection, rheumatism, or other inflammatory diseases. The study was approved by the local ethics committee. There were no significant differences in age, blood pressure, and lipid levels between the cerebral infarction group and the control group （P 〉 0.05）, and this suggested that the baseline data of both groups were comparable. METHODS： Fasting venous blood was drawn from cerebral infarction patients 24 hours after cerebral infarction attack and from control subjects 24 hours after hospitalization. A latex-enhanced immunoturbidimetric assay and an enzyme-linked immunosorbent assay were used to detect the levels of hs-cRP, IL-6, and TNF- α in the serum. MAIN OUTcOME MEASURES： The levels of hs-cRP, 1L-6, and TNF- α in the serum in both groups. RESULTS： Forty cerebral infarction patients and thirty-five control subjects were included in the final analysis without any lo

关键词： high-sensitivity c-reactive protein interleukin tumor necrosis factor-alpha: elderly males cerebral infarction

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Distribution of high-sensitivity c-reactive protein Status in an Urban Population in china

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Biomedical and Environmental Sciences 2020年第6期33卷 396-402页

作者： TANG Yan Bin HUO Jun Sheng HUANG Jian LI Hong PIAO Jian Hua SUN Jing WANG Li Juan Key Laboratory of Trace Element Nutrition MOH National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Beijing center for Disease control and Prevention Beijing 100013China

Objectives To evaluate the distribution by age and sex of serum high-sensitivity c-reactive protein(hscRP)in an urban chinese population and to provide a profile prediction for the risk of bacterial infection,inflammatory diseases,or tissue damages in the *** Serum hscRP was determined using the Roche Tina-quant immuno-turbidimetric assay on a Hitachi 7600–010 automatic biochemical analyzer(Roche Diagnostics)in 1,572 males and 1,800 females,including 78 pregnant women,who were derived from the National Health and Nutrition Survey in2010–*** The average hscRP concentration in urban china was 0.68 mg/L for males and 0.65 mg/L for *** differences in hscRP were found among different age groups(Pcant differences among the 6–11,45–59,and≥60-year-old groups in the comparison of hscRP between males and females in large ***,hscRP concentration was significantly higher in men aged 12–17 and 18–44 years than in *** The distribution of the hscRP status of residents in large cities in china was influenced by age and gender,and the hscRP levels of both sexes increased gradually with *** addition,hscRP concentration was higher in healthy pregnant women than in non-pregnant *** on our results,we recommend that this parameter be included in future national and international screening for early detection of various illnesses.

关键词： high-sensitivity c-reactive protein Urban population Inflammation Distribution

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Associations of plasma homocysteine and high-sensitivity c-reactive protein levels with arterial stiffness in chinese population： a community-based study

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chinese Medical Journal 2012年第1期000卷 44-49页

作者： FENG Sheng-qiang YE Ping LUO Lei-ming XIAO Wen-kai BAI Yong-yi FENG Dan LIU De-jun WU Hong-mei XU Ru-yi BAI Jie Department of Geriatric cardiology Chinese People＇s Liberation Army General Hospital Beijing100853 China Department of Geriatric cardiology Department of MedicalStatistics Chinese People＇s Liberation Army General Hospital Beijing100853 China Department of Geriatric cardiology Department ot IZhmcal 131oclaemlstry Chinese People＇s Liberation Army General Hospital Beijing 100853 China

Background Arterial stiffness increases with age and is also associated with traditional cardiovascular risk factors. Little is known about the relations of homocysteine and high-sensitivity c-reactive protein （hs-cRP） to arterial stiffness in the chinese community. The aim of the present study was to investigate the association of plasma homocysteine and hs-cRP levels with arterial stiffness in a community-based cohort. Methods We related levels of homocysteine and hs-cRP to four measures of arterial stiffness （carotid-femoral pulse wave velocity （PWV）, carotid-radial PWV, carotid-ankle PWV and heart rate corrected augmentation index） in 1680 participants from two communities of Beijing, china. Arterial stiffness was measured within two days of the time of biomarker measurement. Results In univariate analysis, homocysteine was positively associated with the carotid-femoral PWV （r=0.211, P 〈0.0001）, carotid-radial PWV （r=0.120, P 〈0.0001） and carotid-ankle PWV （r=0.148, P 〈0.0001）, whereas it was inversely related to the augmentation index （r= -0.052, P=0.016）. Hs-cRP was positively associated with the carotid-femoral PWV （r=0.074, P=0.001） and carotid-ankle PWV （r=0.050, P=0.02）. In multiple-adjusted models （R2=0.57）, homocysteine levels remained a significant determinant of the carotid-femoral PWV （standardized 13=0.065, P=0.007）, whereas the association of hs-cRP with measurements of arterial stiffness was not present. conclusions In the chinese population, plasma homocysteine levels are associated with alterations of aortic stiffness, whereas plasma levels of hs-cRP are not independently related to artery stiffening.

关键词： epidemiology arterial stiffness," homocysteine high-sensitivity c-reactive protein

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Value of N-Terminal Pro B-Type Natriuretic Peptide,high-sensitivity c-reactive protein,and Homocysteine Levels in Predicting cardiovascular Events in chronic Heart Failure Patients After Discharge

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Proceedings of Anticancer Research 2023年第2期7卷 22-27页

作者： Qian Yu Linya Zhao Yinyin chen Qing Zhao Affiliated Hospital of Hebei University Baoding 071000Hebei ProvinceChina

Objective:To investigate the value of N-terminal pro B-type natriuretic peptide(NT-proBNP),high-sensitivity c-reactive protein(hs-cRP),and homocysteine(Hcy)levels in predicting cardiovascular events(cV)in patients with chronic heart failure(cHF).Methods:A total of 63 patients with cHF admitted to our hospital between June 2019 and July 2021 were *** NT-proBNP,hs-cRP,and Hcy levels were detected at discharge,and a 12-month follow-up was done after their discharge to collect clinical *** collected data were inclusive of data from 21 cHF patients with cardiovascular disease and 42 cHF patients without cardiovascular *** effect of NT-proBNP,hs-cRP,and Hcy levels on the occurrence of cV was ***:The levels of NT-proBNP,hs-cRP,and Hcy in the group with cardiovascular disease were significantly higher than those in the group without cardiovascular disease(PcRP,and Hcy at discharge had certain value in predicting short-term cV in cHF patients(Pconclusion:NT-proBNP,hs-cRP,and Hcy levels can be used to predict cV in cHF patients,thus having clinical application value.

关键词： chronic heart failure N-terminal pro B-type natriuretic peptide Homocysteine high-sensitivity c-reactive protein

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N-terminal pro-brain natriuretic peptide but not high-sensitivity c-reactive protein is related to severity of coronary artery stenosis in patients with acute coronary syndrome

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Journal of Geriatric cardiology 2010年第2期7卷 101-105页

作者： Shi-Jun Li Zhi-Jun Sun Dan-Dan Li Geng Qian Ting-Shu Yang Xiao-Ying Li Department of Geriatric cardiology Chinese PLA General HospitalBeijing 100853China Department of cardiology Chinese PLA General HospitalBeijing 100853China

Objective Biochemical indicators such as N-terminal pro-brain type natriuretic peptide（NT pro-BNP）and high-sensitivity creactive protein（hscRP）predict mortality in acute coronary syndrome（AcS）.However,little is known about the relationship of these factors with severity of coronary artery stenosis in patients *** Three hundred and thirty-one subjects including 246 unstable angina pectoris patients and 85 myocardial infarction patients were recruited and classified into two groups：single-vessel disease group（1-vessel disease,n=93）and multiple-vessel disease group（≥2-vessels disease,n=238）according to selective coronary *** levels of NT pro-BNP and hscRP were measured and severity of coronary stenosis was determined by Gensini *** NT pro-BNP but not hscRP level was higher in patients with myocardial infarction than in patients with unstable angina *** patients with multiple-vessel disease had significantly higher NT pro-BNP level but not hscRP compared with those with single-vessel *** pro-BNP levels increased significantly as left ventricle（LV）function decreased,and only NT proBNP but not hscRP level was related to Gensini score of severity of coronary stenosis in *** NT proBNP but not hscRP level is related to severity of coronary artery stenosis in patients in AcS.

关键词： N-terminal pro-brain natriuretic peptide high-sensitivity c-reactive protein coronary artery stenosis acute coronary syndrome

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high sensitivity c-reactive protein Associated with Different Health Predictors in Middle-Aged and oldest old chinese

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Biomedical and Environmental Sciences 2012年第3期25卷 257-266页

作者： ZHAI Yi SHI Xiao Ming FITZGERALD Simon Michael QIAN Han Zhu KRAUS Virginia B SERENY Melanie HU Perry YIN Zhao Xue XU Jian Wei ZENG Yi chinese center for Disease control and Prevention Beijing 102206 China SUNY Downstate college of Medicine NY 11218 USA Division of Epidemiology Vanderbilt University School of Medicine TN 37203-1738 USA Department of Sociology Duke University Durham NC 27708 USA Department ofSociology Duke University Durham NC 27708 USA Ronald Reagan UcLA Medical center Los Angeles CA90095USA center for the Study of Aging and Human Development and Geriatric Division of Medical SchoolDuke University Box 3003 Room 1506 BUSSE Building Durham NC27710 USA china center for EconomicResearch National School of Development at Peking University Beij'ing 100087 China

Objective To describe the distribution of plasma high sensitivity c-reactive protein （hscRP） and explore the relationship between hscRP and metabolic risk factors among residents living in longevity areas of china. Methods 268 individuals aged between 40 and 59 years and 506 individuals aged over 90 years were selected from 5 longevity areas of china to participate in a cross section longitudinal cohort study. The participants were interviewed with general health related questionnaire to collect their demographic, behavioral and lifestyle data, as well as their chronic conditions, and meanwhile their physical and biomedical parameters including waist circumference （Wc）, blood pressure （BP）, hscRP, plasma lipids, and fasting blood glucose （FBG） were measured. Results The median of hscRP was 0.99 mg/L in the middle-aged group and 2.76 mg/L in the oldest old group. No significant gender difference was observed between the above two groups. Among the oldest old individuals, 36.56% had an hscRP level 〉3.0 mg/L. The prevalence of high hscRP was 26.79% in the middle-aged group. The results of stepwise multiple linear regression analyses showed that HDL-c was independently associated with In （hscRP） concentration in the middle-aged group, whereas In （TG）, HDL-c and FBG were correlated after adjustment for gender, study site, smoking, drinking, education and BMI in the oldest old group. conclusion HDL-c is a stronger predictor of elevated hscRP than other metabolic factors in the middle-aged population. For the oldest old persons, high TG, low HDL-c, and FBG predict elevated plasma hscRP.

关键词： high-sensitivity c-reactive protein Blood lipids Fasting blood glucose Middle-aged Oldestold individuals Longevity china

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Negative Association of circulating MicroRNA-126 with high-sensitive c-reactive protein and Vascular cell Adhesion Molecule-1 in Patients with coronary Artery Disease Following Percutaneous coronary Intervention

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chinese Medical Journal 2016年第23期129卷 2786-2791页

作者： Jun-Nan Wang You-You Yan Zi-Yuan Guo Ya-Juan Jiang Lu-Lu Liu Bin Liu Department of cardiology The Second Hospital of Jilin University Changchun Jilin 130041 China

Background： Percutaneous coronary intervention （PcI） causes endothelial damage, resulting in an inflammatory response with elevation of markers such as high-sensitive c-reactive protein （hs-cRP） and vascular cell adhesion molecule-1（VcAM-1）, which are associated with restenosis after PcI. Evidence suggests that microRNA-126 （miR-126） plays an important role in vascular inflammation, but its correlation with Pcl-mediated inflammation has not been investigated. In this study, we investigated the effect of PcI on circulating miR-126 and inflammation markers such as hs-cRP and VcAM-1. Methods： We enrolled 130 patients with coronary artery disease （cAD） in the Second Hospital of Jilin University from October 2015 to December 2015. Among them, 82 patients with cAD, defined as at least one major epicardial vessel with 〉70% stenosis who planned to undergo PcI, were divided into acute coronary syndrome （AcS） group （46 patients） and stable angina （SA） group （36 patients）. Forty-eight patients confirmed by coronary angiography without PcI were used as controls. The plasmas of all patients were collected prior to PcI and at 30 min, 24 h, and 72 h after PcI. The plasma VcAM-1 and hs-cRP were detected by enzyme-linked immunosorbent assay, and the miR-126 was evaluated by quantitative reverse transcription-polymerase chain reaction. Results： Plasma concentrations of hs-cRP and VcAM-I in patients with either AcS （n = 46） or SA （n = 36） were significantly higher than in controls （n = 48）（P 〈 0.01） prior to PcI, and increased further at 24 h and 72 h after PcI, compared with prior PcI. Moreover, VcAM-1 was positively correlated with balloon time and pressure. In contrast, the plasma concentration of miR-126 was significantly lower in patients with cAD than in controls, and further decreased with time post-Pcl. A negative correlation was observed between miR-126 and hs-cRP and VcAM-1 at 72 h after PcI. conclusion： There was a negative correlation of miR-126 with the PcI-induced marke

关键词： high-sensitivity c-reactive protein MicroRNA126 Percutaneous coronary Intervention Vascular cell Adhesion Molecule- 1

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Predicted pro-inflammatory hs-cRP score and non-alcoholic fatty liver disease

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Gastroenterology Report 2023年第1期11卷 462-468页

作者： Akinkunmi Paul Okekunle Jiyoung Youn Sihan Song Goh Eun chung Sun Young Yang Young Sun Kim Jung Eun Lee Department of Food and Nutrition College of Human EcologySeoul National UniversitySeoulKorea Research Institute of Human Ecology Seoul National UniversitySeoulKorea Healthcare System Gangnam center Healthcare Research InstituteSeoul National University HospitalSeoulKorea

Background:Non-alcoholic fatty liver disease(NAFLD)is a major contributor to liver diseases globally,yet there are limited studies investigating the impact of diet and lifestyle factors on its *** study aimed to examine the association between the prevalence of NAFLD and predicted pro-inflammatory high-sensitivity c-reactive protein(hs-cRP)***:We included 1,076 Korean adults who underwent a medical examination at the Seoul National University Hospital Gangnam Healthcare center in Korea between May and December 2011 and updated in *** predicted pro-inflammatory hs-cRP score was derived from pro-inflammatory demographic,lifestyle,dietary,and anthropometric factors,and NAFLD was diagnosed using liver ***-adjusted odds ratios(ORs)and 95%confidence intervals(cIs)of NAFLD odds according to predicted pro-inflammatory hs-cRP score were estimated using logistic regression at a two-sided Pcipants,320 had *** multivariable-adjusted ORs and 95%cIs for NAFLD by tertiles of predicted pro-inflammatory hs-cRP score were 1.00,3.30(2.06,5.30),18.25(10.47,31.81;Pcombined,1.00,1.77(1.10,2.84),and 3.26(2.02,5.28;Pcted pro-inflammatory hs-cRP score was associated with higher odds of *** dietary and lifestyle changes related to lower inflammation might be a valuable strategy for preventing NAFLD.

关键词： non-alcoholic fatty liver disease fatty liver high-sensitivity c-reactive protein pro-inflammation

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Protective effect of LIF-huM Scs on the retina of diabetic model rats

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1508-1517页

作者： Shan-Na chen Zhi-Gang Xu Ying-Xue Ma Song chen Guang-Hui He Mei Han Xiang Gao Jun-Hua Wang Bin Wu Jian Wang clinical college of Ophthalmology Tianjin Medical UniversityTianjin 300070China Tianjin Eye Hospital Tianjin Eye InstituteTianjin Key Lab of Ophthalmology and Visual ScienceTianjin 300020China Xiamen Kehong Eye Hospital Xiamen 361000Fujian ProvinceChina Department of Ophthalmology Baoan Central HospitalShenzhen 518000China Department of Ophthalmology Tianjin First Central HospitalTianjin 300192China Department of Vitreous and Retinopathy Tianjin Eye HospitalTianjin Eye InstituteTianjin Key Lab of Ophthalmology and Visual ScienceTianjin 300020China Department of Ophthalmology Tianjin Eye HospitalTianjin Eye InstituteTianjin Key Lab of Ophthalmology and Visual ScienceTianjin 300020China Studying for a Doctor of Medicine Degree from Nankai University Tianjin 300000China

AIM:To investigate the protective effect of human umbilical cord mesenchymal stem cells(hUcMScs)modified by the LIF gene on the retinal function of diabetic model rats and preliminarily explore the possible ***:A stably transfected cell line of hUcMScs overexpressing leukemia inhibitory factor(LIF)was *** was verified by fluorescent quantitative polymerase chain reaction(qPcR).Forty-eight adult Sprague-Dawley rats were randomly divided into a normal control group(group A),streptozotocin-induced diabetic control group(group B),diabetic rats at 3mo injected with empty vector-transfected hUcMScs(group c)or injected with LIF-hUcMScs(group D).Four weeks after the intravitreal injection,analyses in all groups included retinal function using flash electroretinogram(F-ERG),retinal blood vessel examination of retinal flat mounts perfused with fluorescein isothiocyanate-dextran(FITcdextran),and retinal structure examination of sections using hematoxylin and eosin *** levels of adiponectin(APN),high-sensitivity c-reactive protein(hscRP),and neurotrophin-4(NT-4)in each group was detected using immunohistochemistry,PcR,Western blotting,and ELISA,***:A stable transgenic cell line of LIF-hUcMScs was constructed.F-ERG and FITc-dextran examinations revealed no abnormalities of retinal structure and function in group A,severe damage of the retinal blood vessels and function in group B,and improved retinal structure and function in group c and especially group ***,ELISA,and Western blot analyses revealed progressively higher APN and NT-4 expression levels in groups B,c,and D than in group ***-cRP expression was significantly higher in group B than in groups A,c,and D,and was significantly higher in group c than in group D(PcONcLUSION:LIF-hUcMScs protect the retina of diabetic rats by upregulating APN and NT-4 expression and downregulating hs-cRP expression in the retina.

关键词： leukemia inhibitory factor human umbilical cord mesenchymal stem cells diabetic retinopathy diabetic rats adiponectin high-sensitivity c-reactive protein neurotrophin-4

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Journal of clinical and Nursing Research 2022年第1期6卷 15-21页

作者： Yuxi Shi Hongmei Ding Deqin Geng Xuzhou Medical University Xuzhou 221002Jiangsu ProvinceChina Department of Neurology Zhongwu Hospital of Suqian CitySuqian 223800Jiangsu ProvinceChina Affiliated Hospital of Xuzhou Medical University Xuzhou 221002Jiangsu ProvinceChina

Objective:To study the related factors of aspirin resistance(AR)in acute ischemic ***:A total of 138 patients with acute ischemic stroke treated in hospital affiliated to Xuzhou medical university from August 2016 to August 2018 were the study subjects,examine his medical data from the *** were divided into the AR group(40 cases)and the non-AR group(98 cases)according to whether AR ***,disease history,biochemical indicators and *** compared between the two *** independent risk factors of AR were investigated using univariate analysis and logistic regression ***:40 cases of AR occurred in 138 patients,with an incidence rate of 28.99%.Diabetes,platelet count(PLT),microRNA-19a(m iR-19a)expression,smoking,high-sensitivity c-reactive protein(hs-cRP),Low-density lipoprotein cholesterol(LDL-c),fibrinogen(FIB)and age difference between the AR group and non-AR group was statistically significant(Pc acid(UA),high-density lipoprotein cholesterol(HDL-c),triglycerides(TG),homocysteine(Hcy),total cholesterol(Tc),and alanine aminotransferase(ALT)between the two groups were not significantly different(P>0.05).Logistic regression analysis showed that the independent risk factors for AR in acute ischemic stroke were diabetes(OR=2.773,95%cI:1.102~5.065,P=0.025),miR-19a(OR=3.021,95%cI:1.322~6.545,P=0.021),hs-cRP(OR=2.719,95%cI:1.301~5.022,P=0.028)and smoking(OR=1.983,95%cI:1.114~3.887,P=0.040).conclusion:The incidence of AR is higher in acute ischemic *** factors include diabetes,miR-19a expression,hs-cRP,smoking,*** intervention measures can be taken to reduce the risk of AR and improve acute ischemic stroke prognosis.

关键词： Acute ischemic stroke Aspirin resistance Related factors Diabetes MicroRNA-19a high-sensitivity c-reactive protein Smoking

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