Study on Related Factors of Aspirin Resistance in Acute Ischemic Stroke
作者机构：Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina Department of NeurologyZhongwu Hospital of Suqian CitySuqian 223800Jiangsu ProvinceChina Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina
出 版 物：《Journal of Clinical and Nursing Research》 (临床护理研究（英文）)
年 卷 期：2022年第6卷第1期
页 面：15-21页
主 题：Acute ischemic stroke Aspirin resistance Related factors Diabetes MicroRNA-19a High-sensitivity C-reactive protein Smoking
摘 要：Objective:To study the related factors of aspirin resistance(AR)in acute ischemic ***:A total of 138 patients with acute ischemic stroke treated in hospital affiliated to Xuzhou medical university from August 2016 to August 2018 were the study subjects,examine his medical data from the *** were divided into the AR group(40 cases)and the non-AR group(98 cases)according to whether AR ***,disease history,biochemical indicators and *** compared between the two *** independent risk factors of AR were investigated using univariate analysis and logistic regression ***:40 cases of AR occurred in 138 patients,with an incidence rate of 28.99%.Diabetes,platelet count(PLT),microRNA-19a(m iR-19a)expression,smoking,high-sensitivity C-reactive protein(hs-CRP),Low-density lipoprotein cholesterol(LDL-C),fibrinogen(FIB)and age difference between the AR group and non-AR group was statistically significant(P0.05).Logistic regression analysis showed that the independent risk factors for AR in acute ischemic stroke were diabetes(OR=2.773,95%CI:1.102~5.065,P=0.025),miR-19a(OR=3.021,95%CI:1.322~6.545,P=0.021),hs-CRP(OR=2.719,95%CI:1.301~5.022,P=0.028)and smoking(OR=1.983,95%CI:1.114~3.887,P=0.040).Conclusion:The incidence of AR is higher in acute ischemic *** factors include diabetes,miR-19a expression,hs-CRP,smoking,*** intervention measures can be taken to reduce the risk of AR and improve acute ischemic stroke prognosis.
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