Associations of plasma homocysteine and high-sensitivity C-reactive protein levels with arterial stiffness in Chinese population： a community-based study

作     者：FENG Sheng-qiang YE Ping LUO Lei-ming XIAO Wen-kai BAI Yong-yi FENG Dan LIU De-jun WU Hong-mei XU Ru-yi BAI Jie 

作者机构：Department of Geriatric CardiologyChinese People＇s Liberation Army General Hospital Beijing100853 China Department of Geriatric Cardiology Department of MedicalStatistics Chinese People＇s Liberation Army General Hospital Beijing100853 China Department of Geriatric Cardiology Department ot IZhmcal 131oclaemlstry Chinese People＇s Liberation Army General Hospital Beijing 100853 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2012年第125卷第1期

页      面：44-49页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：This work was supported by the grants from the National Natural Science Foundation of China (No. 30872713)  Beijing Natural Science Foundation (No. 7082083) and Research Fund of Capital Medical Development (No. 2009-1038) to Dr. YE Ping. The authors declare no conflicts of interest 

主　　题：epidemiology arterial stiffness," homocysteine high-sensitivity C-reactive protein 

摘      要：Background Arterial stiffness increases with age and is also associated with traditional cardiovascular risk factors. Little is known about the relations of homocysteine and high-sensitivity C-reactive protein （hs-CRP） to arterial stiffness in the Chinese community. The aim of the present study was to investigate the association of plasma homocysteine and hs-CRP levels with arterial stiffness in a community-based cohort. Methods We related levels of homocysteine and hs-CRP to four measures of arterial stiffness （carotid-femoral pulse wave velocity （PWV）, carotid-radial PWV, carotid-ankle PWV and heart rate corrected augmentation index） in 1680 participants from two communities of Beijing, China. Arterial stiffness was measured within two days of the time of biomarker measurement. Results In univariate analysis, homocysteine was positively associated with the carotid-femoral PWV （r=0.211, P 〈0.0001）, carotid-radial PWV （r=0.120, P 〈0.0001） and carotid-ankle PWV （r=0.148, P 〈0.0001）, whereas it was inversely related to the augmentation index （r= -0.052, P=0.016）. Hs-CRP was positively associated with the carotid-femoral PWV （r=0.074, P=0.001） and carotid-ankle PWV （r=0.050, P=0.02）. In multiple-adjusted models （R2=0.57）, homocysteine levels remained a significant determinant of the carotid-femoral PWV （standardized 13=0.065, P=0.007）, whereas the association of hs-CRP with measurements of arterial stiffness was not present. Conclusions In the Chinese population, plasma homocysteine levels are associated with alterations of aortic stiffness, whereas plasma levels of hs-CRP are not independently related to artery stiffening.