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ginsenoside rg3 Promotes the Survival and Migration of Trophoblast Cells in a Rat Model of Gestational Hypertension by Regulating miR-100a/Insulin Growth Factor-2 Axis

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 65-74页

作者： Xiu-Mei Fan Li Yang Gang Zhao Sen-Ye Huo Yan Gao Department of Obstetrics Xingtai Third HospitalXingtaiChina Department of Obstetrics Xingtai Maternal and Child Health Care HospitalXingtaiChina

Objective:Preeclampsia(PE)is a common complication during ***-100a is expressed in the placenta and regulates the survival and development of placental *** growth factor-2(IGF-2)may serve as its downstream *** study investigated the protective mechanisms of ginsenoside rg3 against PE in rat *** and Methods:LPS-induced rat PE models were suitable for intravenous administration of the highly expressed miR-100a ginsenoside rg3 lentiviral *** trophoblasts were cultured in vitro for JEG-3,and PE cell models were *** vivo effects on tumor growth and apoptosis were *** rg3 was treated with different concentrations of shRNA,miR-100a analogs,inhibitors,or *** and the expression of autophagy-related proteins were *** activity and migration were determined using Cell Counting Kit-8 and Transwell *** drugs strongly inhibited trophoblasts under normal conditions with some synergy between ***-luciferase return assay confirmed the binding affinity of miR-100a for ***:In response to rg3,autophagy and the expression of autophagy-related proteins LC3-I/II,Beclin1,and SQSTM1 were reduced in PE rat placental ***3 inhibited autophagy in JEG-3 cells and promoted JEG-3 survival and migration in a concentration-dependent ***-100a upregulated PE *** results suggested that autophagy was a vital signaling ***3 intervention inhibited miR-100a expression and miR-100a downregulated IGF-2 expression in placental tissues and promoted autophagy,thereby inhibiting JEG-3cell survival and *** rats,rg3 inhibited PE development by regulating the activity of the miR-100a-IGF-2 signaling ***:ginsenoside rg3 positively regulates the miR-100a-IGF-2 axis and protects PE rats by inhibiting trophoblastic autophagy and promoting trophoblastic cell survival and migration.

关键词： ginsenoside rg3 inflammatory response miR-100a/insulin growth factor-2 axis preeclampsia pregnancy-induced hypertension

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Engineering of triterpene metabolism and overexpression of the lignin biosynthesis gene PAL promotes ginsenoside rg3 accumulation in ginseng plant chassis

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Journal of Integrative Plant Biology 2022年第9期64卷 1739-1754页

作者： Lu Yao Huanyu Zhang Yirong Liu Qiushuang Ji Jing Xie Ru Zhang Luqi Huang Kunrong Mei Juan Wang Wenyuan Gao School of Pharmaceutical Science and Technology Tianjin UniversityTianjin300072 China Wenzhou Safety(Emergency)Institute of Tianjin University Wenzhou325000 China Key Laboratory of Systems Bioengineering Ministry of EducationTianjin UniversityTianjin300072 China National Resource Center for Chinese Meteria Medica China Academy of Chinese Medical SciencesBeijing100700 China

The ginsenoside rgfound in Panax species has extensive pharmacological properties,in particular anti-cancer ***,its natural yield in Panax plants is ***,we report a multimodular strategy to improve yields of rgin a Panax ginseng chassis,combining engineering of triterpene metabolism and overexpression of a lignin biosynthesis gene,phenylalanine ammonia lyase(PAL).We first performed semi-rational design and site mutagenesis to improve the enzymatic efficiency of Pq3-O-UGT2,a glycosyltransferase that directly catalyzes the biosynthesis of rgfrom ***,we used clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing to knock down the branch pathway of protopanaxatriol-type ginsenoside biosynthesis to enhance the metabolic flux of the protopanaxadiol-type ginsenoside *** of PAL accelerated the formation of the xylem structure,significantly improving ginsenoside rgaccumulation(to 6.19-fold higher than in thecontrol).Wecombinedoverexpression of the ginsenoside aglycon synthetic genes squalene epoxidase,Pq3-O-UGT2,and PAL with CRISPR/Cas9-based knockdown of CYP716A53v2 to improve ginsenoside ***,we produced ginsenoside rgat a yield of 83.6 mg/L in a shake flask(7.0 mg/g dry weight,21.12-fold higher than with wild-type cultures).The highproduction system established in this study could be a potential platform to produce the ginsenoside rgcommercially for pharmaceutical use.

关键词： catalysis ginsenoside rg3 metabolism regulation phenylalanine ammonia lyase

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ginsenoside rg3 reduces body weight by regulating fat content and browning in obese mice

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Journal of Traditional Chinese Medical Sciences 2021年第1期8卷 65-71页

作者： Qianqian Mu Jiacheng Zuo Dandan Zhao Xiaoshan Zhou Jing Hua Ying Bai Fangfang Mo Xin Fang Min Fu Sihua Gao Hospital Office Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Endocrinology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Research Institute of McGill University Health Center McGill UniversityMontreal H4A 3J1Canada

Objective:To determine the effects of ginsenoside rg3 on the body weight of C57BL/6J obese mice and to investigate its underlying weight loss mechanisms with a focus on white fat browning-related ***:Eight-week-old C57BL/6J male mice were fed a high-fat diet for 12 successive weeks to construct the obese model.C57BL/6J male mice were fed a standard chow diet to construct normal control *** 8 weeks of intervention with ginsenoside rg3,the food intake,body weight,body fat mass,blood sugar,and lipid profiles of the mice in each group were *** and eosin(HE)staining was used to observe the histological morphology of the adipose ***-time polymerase chain reaction(RT-PCR)and Western blotting(WB)were applied to detect the gene and protein expression levels of peroxisome proliferators-activated receptor gama(PPArg),Peroxisome proliferatoractivated receptor-gamma coactivator-1alpha(PGC-1a),PR domain containing 16(PRDM16),and uncoupling protein 1(UCP-1).Results:Compared to normal control group mice,the body weight,food intake,body fat composition,and blood lipid levels of model group mice increased *** 8 weeks of intervention with ginsenoside rg3,body weight,body fat composition,food intake,and blood lipid profiles *** staining showed that ginsenoside rg3 can improve white adipocyte hypertrophy to a certain *** and WB demonstrated that ginsenoside rg3 can increase the mRNA and protein expression levels of PPArg,PGC-1a,PRDM16,and UCP-1 in the adipose tissues of obese ***:The weight reduction effect of ginsenoside rg3 may be related to the promotion of white fat browning.

关键词： ginsenoside rg3 White fat Browning Obesity

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Preparation and Characterization of Biodegradable Polylactide(PLA) Microspheres Encapsulating ginsenoside rg3

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Chemical Research in Chinese Universities 2008年第5期24卷 588-591页

作者： LIU Cheng-bai ZHANG Di LI De-guan JIANG Dan CHEN Xia College of Life Science Jilin University Changchun 130021 P. R. China

In this study, the process of a biodegradable polylactide（PLA） microsphere encapsulating ginsenoside rg3 was first studied by the emulsion solvent evaporation method, for enhancing solubility and stability of ginsenoside rg3. Alabum was also first used as a modifier in this method. The mean diameter of the prepared PLA microspheres containing rg3 was 40 μm. ginsenoside rg3 released from the microspheres was studied by HPLC and detected by UV. It was found that the drug release curve fitted the Model Heller-Baker best.

关键词： Microparticle ginsenoside rg3 PEA Controlled release

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Investigation on the mechanism of ginsenoside rg3 in treating murine primary mammary tumor

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Frontiers of Medicine 2009年第4期3卷 421-425页

作者： Hongbo TANG Zirong YE Yuping REN Zhanyong ZHU Yiping WU Department of General Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

A murine primary mammary tumor model was established to investigate the treatment with ginsenosides *** relationship between ginsenosides rg3 and primary mammary tumor was *** tumor was induced by using the 7,12-dimethybenz(a)anthracene(DMBA).ginsenoside rg3 was employed for *** incidence of mammary tumor in every group was compared,and the expressions of vascular endothelial growth factor(VEGF)and microvessel density(MVD)were detected by immunohistochemical *** cell cycle and apoptosis percentage were determined by means ofﬂow *** incidence of tumor in treatment group was signiﬁcantly lower than that in control group(60.00%vs 33.33%,Pginsenoside rg3 can play an antitumor role in primary mammary tumor model by inhibiting angiogenesis,cell cycle progression,and promoting cell apoptosis.

关键词： ginsenoside rg3 mammary tumor mice

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Novel ginsenoside rg3-based and Paclitaxel-coloaded liposomes for glioma target therapy

Novel Ginsenoside Rg3-based and Paclitaxel-coloaded liposome...

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2018年第十二届中国药物制剂大会

作者：朱颖 Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University ＆ Key Laboratory of Smart Drug Delivery Ministry of Education

Accumulation of most currently used anti-tumor agents in malignant glioma is far from perfect because of their non-targeted nature and difficulty in crossing the blood-brain barrier/blood-tumor barrier（BBB/BBTB）. Attempts to overcome this challenge have been focused on nanoparticle drug delivery system, such as nanoparticles, liposomes and other self-assembling systems. And various ligands are usually modified on the surface of these nanocarriers to construct brain-targeted delivery systems that can overcome BBB/BBTB barriers, target to tumor cells. However, most target ligands are polypeptides, whose preparation costs are high and process is complicated, and they often ignore the complicated brain tumor mircroenvironment（TME）, which contains many different noncancerous cell types in addition to cancer cells, also might limite the success of glioma treatment. Therefore, it is imperative to develop new nano preparations that can not only across BBB/BBTB but also regulate the TME to improve drug delivery efficiency and glioma treatment. In our previous studies, we have successfully developed a novel ginsenoside Rh2-based liposomes. It is a novel liposome prepared by replacing ginsenoside Rh2 with *** can not only break the clinical limitations of traditional liposomes due to the various defects of cholesterol but also mediate endocytosis through glucose receptors to the uptake of tumor cells. GLUT-1 can mediate the delivery across the BBB for those substances with similar structures of glucose, including mannose and glucose analogs. ginsenoside rg3 resembles with Rh2 in structure, and it contains 2 glucose molecules, which may account for helping the liposome cross the BBB/BBTB. Moreover, ginsenoside rg3 has good anti-tumor activity. Besides when it combinate with other chemotherapeutic agents may lead to an improved treatment efficacy by synergistic effects. Furthermore, ginsenoside rg3 also plays a role in the improvement of host immunity in tumor-bearing

关键词： ginsenoside rg3 liposome brain Tumor targeting paclitaxel TAM TME

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Anti-angiogenic Effects of Cisplatin Combined with ginsenoside rg3 in Nude Mice Cervical

Anti-angiogenic Effects of Cisplatin Combined with Ginsenosi...

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第十一届国际人工血液大会

作者： Duon Ying-chun Hu Ping Huang Guong-rong Yong Bo Ren Qing Zhou Yu-ping.The People’s Hospital of Yunyang Medical College Shiyan 442000 China

＜正＞Objective To study the anti-angiogenic effects and anti-tumor effect of cisplatin combined with ginsenoside Re3 in nude mice cervical *** 28 female nude mice were randomly divided into 4 groups to receive Saline（0.5 ml,qd）,rg3（5mg/kg）alone,Cisplatin（5mg/kg）alone and Re3（5 mg/kg）combined with Cisplatin（Smg/kg）***3 was given by gastrogavage once a day for 5 weeks,Cisplatin 3 was injected introperitoneally once 4 clays for 5 *** after treatmeat being stopping,mice were killed and the sizes of solid tumors were measured,the intratumor MVD was examined by immunohistochemical *** The tumor weight of treated group was significantly lower than that of control *** tumor weight of Re3 combined with Cisplatin group was lower than other *** MVD value of Re3 group was significantly lower than that of Cisplatin group and control *** Re3 combined with Cisplatin can significantly inhibit the growth of transplanted human Cervical Cancer in nude ***3 can obviously reduce the intratumoral MVD through inhibiting angiogenesis of malignant tumor.

关键词： ginsenoside rg3 Cisplatin angiogenesis microvessel density

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Isolation and Properties of A Novel β-glucosidase from Fusarium Proliferatum CGMCC1495 Hydrolyzing ginsenoside rg3 to Rh2

Isolation and Properties of A Novel β-glucosidase from Fusa...

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The 12th Asian Pacific Confederation of Chemical Engineering Congress

作者： A.Jin-Huan Su B.Jian-He Xu~* C.Hui-Lei Yu * State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China

ginsenosides are reported to be one of the important physiologically active materials in gin- seng,and they have a variety of biological *** Rh,which has shown a suppressing effect on cell growth of various cancer cel... 详细信息

关键词： isolation properties,-glucosidase Fusarium proliferatum ginsenoside rg3 ginsenoside Rh2

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Enrichment of the less polar ginsenoside (rg3) from ginseng grown in New Zealand by post-harvest processing and extraction

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Traditional Medicine Research 2021年第4期6卷 136-149页

作者： Wei Chen Wen-Liang Xu Dan-Xia Shi Prabhu Balan David Popovich School of Food and Advanced Technology Massey UniversityPalmerston North 4442New Zealand Riddet Institute Massey UniversityPalmerston North 4442New Zealand

Background:Previous studies showed that New Zealand-grown ginseng contains an abundance of ginsenosides and that rare less polar ginsenosides,such as rg3,exhibit more pharmacological activities than polar ginsenosides,which are the major components of ***:The ginsenoside profile of New Zealand-grown Panax ginseng was manipulated by treatment with acetic acid,sodium hydroxide,pH,and high *** abundance of 23 ginsenosides extracted by different treatments was quantified using high-performance liquid ***:Treatment with 0.5 mol/L acetic acid can stimulate the degradation of polar ginsenosides to less polar ginsenosides(5.6%rg3 was accumulated,P3.0 acetic acid aqueous solution,the majority of the polar ginsenosides were converted into less polar ***,83.46±3.69%(P=0.0360)of the less polar ginsenosides and 41.01±2.39%(P=0.0412)of rg3 were *** contrast,alkali treatment did not convert the polar ginsenosides into less polar ginsenosides at mild temperature and less conversion was observed compared with acid treatment at high ***:This is the first attempt to manipulate the ginsenoside profile of New Zealand-grown *** conditions(high temperature with low pH)may be modified to produce and enrich the less polar ginsenoside fraction(especially rg3)from the total ginseng extract.

关键词： New Zealand grown ginseng Less polar ginsenoside ginsenoside rg3 ginsenoside transformation

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THE CLINICAL EVALUATION OF ANGIOGENESIS INHIBITOR-20(R)-ginsenoside rg_3 IN LUNG CANCER

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Journal of Pharmaceutical Analysis 2003年第2期15卷 176-178,192页

作者：陈明伟姚煜石志红 Department of Respiration First Hospital of Xi’an Jiaotong University

Objective The aim of the study was to make a further evaluation of ginsenoside rg3. Methods The clinical effects of the drug on moderate and advanced lung cancer, including side effects, were observed. Results ginsenoside rg3 improved chemotherapy significantly. The clinical relief rate of patients treated with antiangiogenic agent 20 (R) ginsenoside rg3 was 36.6%, which was higher than that of the patients not treated with it (16.7%)( P 0.05). It provided better treatment on the cancer at early stage than that at advanced stage ( P ginsenoside rg3 can improve clinical therapeutic efficacy and the living qualities of patients significantly.

关键词： ginsenoside rg3 neovascularization lung neoplasma

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