Investigation on the mechanism of ginsenoside Rg3 in treating murine primary mammary tumor

作     者：Hongbo TANG Zirong YE Yuping REN Zhanyong ZHU Yiping WU 

作者机构：Department of General SurgeryTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2009年第3卷第4期

页      面：421-425页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：ginsenoside Rg3 mammary tumor mice 

摘      要：A murine primary mammary tumor model was established to investigate the treatment with ginsenosides *** relationship between ginsenosides Rg3 and primary mammary tumor was *** tumor was induced by using the 7,12-dimethybenz(a)anthracene(DMBA).Ginsenoside Rg3 was employed for *** incidence of mammary tumor in every group was compared,and the expressions of vascular endothelial growth factor(VEGF)and microvessel density(MVD)were detected by immunohistochemical *** cell cycle and apoptosis percentage were determined by means offlow *** incidence of tumor in treatment group was significantly lower than that in control group(60.00%vs 33.33%,P0.05).The average diameter of mammary tumor was(0.86�0.27)cm in control group and(0.39�0.09)cm in treatment group,with the difference being significant between control and treatment groups(P0.01).The MVD value was(31.9�5.3)in control group and(20.1�4.9)in treatment group,*** was a significant difference between the two groups(P0.05).The apoptosis percentage in control group was significantly lower than that in treatment group[(2.47�0.69)%vs(5.67�0.99)%,P0.05].Ginsenoside Rg3 can play an antitumor role in primary mammary tumor model by inhibiting angiogenesis,cell cycle progression,and promoting cell apoptosis.