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Investigating formate tolerance mechanisms in Saccharomyces cerevisiae and its application

Green Carbon 2023年第1期1卷 65-74页

作者： Kai Wang Yining Liu Zhuoheng Wu Yilu Wu Haoran Bi Yanhui Liu Meng Wang Biqiang Chen Jens Nielsen Zihe Liu Tianwei Tan National Energy R&D Center for Biorefnery Beijing Key Lab of BioprocessCollege of Life Science and TechnologyBeijing Advanced Innovation Center for Soft MatterScience and EngineeringBeijing University of Chemical TechnologyNo.15 North 3rd Ring Rd East100029 BeijingPR China Department of Biology and Biological Engineering Chalmers University of TechnologySE41296 GothenburgSweden

Current global energy and environmental crisis have spurred efforts towards developing sustainable biotechnological solutions,such as utilizing CO_(2) and its derivatives as raw *** is an attractive onecarbon source due to its high solubility and low reduction ***,the regulatory mechanism of formate metabolism in yeast remains largely *** study employed adaptive laboratory evolution(ALE)to improve formate tolerance in Saccharomyces cerevisiae and characterized the underlying molecular *** evolved strain was applied to produce free fatty acids(FFAs)under high concentration of formate with glucose *** results showed that the evolved strain achieved a FFAs titer of 250 mg/***,this study sheds light on the regulatory mechanism of formate tolerance and provides a platform for future studies under high concentrations of formate.

关键词： Formate tolerance Adaptive laboratory evolution Saccharomyces cerevisiae free fatty acids

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Therapeutic Strategies for Acne and Its Integrated Traditional and Western Medicine Study

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Chinese Journal of Integrative Medicine 2002年第4期8卷 245-247页

作者：林熙然 Dalian Medical University Liaoning 116011 Institute of Dermatology

It is believed that acne is a multifactorial dis-ease, and its clinical expression depends on the in-teraction of several factors: (1) increased produc-tion of sebum and enlarged sebaceous glands as theresult of androgenic stimulation; (2) obstructionof the follicular duct, due to keratinization of thesebaceous follicle, retention of sebum and blockageof hair follicles by keratinized epithelium, leadingto the formation of a microcomedo; (3) propaga-tion of Propionibacterium acnes(P. Aches); and (4)release of lipases by P. Acnes, resulting in hydrol-ysis of sebum triglycerides into free fatty acids,which irritate the wall of follicle, leading to rup-ture of follicle, irritate the surrounding dermis andinduce inflammatory changes.

关键词： free fatty acids

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Nicotinic acid: Do we know how it works after 55 years of clinical experience?

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World Journal of Pharmacology 2012年第3期1卷 50-54页

作者： Anastazia Kei Moses S Elisaf Department of Internal Medicine School of Medicine University of Ioannina 45110 Ioannina Greece

Nicotinic acid （NA） comprises the oldest hypolipidemic drug, in use since 1955. Despite its established broad spectrum effect on lipid profle and the associated re-duction in cardiovascular morbidity and mortality, the mechanisms by which NA achieves its benefcial effects remain elusive. Regarding the NA-associated reduction in triglyceride and low density lipoprotein cholesterol levels, data are controversial. The prevailing view which suggested that NA inhibits lipolysis and decreases free fatty acid （FFA） release both via activation of adipose tissue G-protein receptor-109A （GPR109A） and via inhibition of hepatic triglyceride synthesis is currently debated by the observation that the initially decreased FFA levels rebound during long-term NA treatment even though the benefcial NA effects on lipid metabo-lism are preserved, while other mechanisms involving modulation of transcription and translation pathways are emerging. In addition, NA has been demonstrated to affect high density lipoprotein （HDL） particles remod-eling in a number of ways, including reducing choles-terol ester transfer protein levels and activity, increas-ing apolipoprotein A-I levels, eliminating HDL hepatic uptake, increasing cholesterol efflux via ATP-binding cassette A1, inhibiting hepatic lipase, thereby overall in-creasing the plasma residence time of HDL and apoA-I with retention of cholesterol esters in HDL. Focus of this article is to present the mechanisms by which NA exerts its broad spectrum hypolipidemic actions.

关键词： Dyslipidemia Nicotinic acid Niacin Mechanisms GPR109A free fatty acids

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Antihypertensive effects of total ginsenosides and regulation of the perturbed metabolism of spontaneously hypertensive rats

Antihypertensive effects of total ginsenosides and regulatio...

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第九届全国药物和化学异物代谢学术会议

作者： A Ji-ye~1,WANG Guang-ji~(1*),HAO Hai-ping~1,HUANG Qing~2,LU Yi-hong~2,YAN Bei~1, ZHA Wei-bin~1,GU Sheng-hua~1,ZHANG Ying~1,LIU Lin-sheng~1,CAO Bei~1,SHI Jian~1,LI Meng-jie~1, WANG Xin-wen~1,ZHAO Chun-yan~1,ZHANG Mei~2,FAN Xia-lei~2 1 Key Laboratory of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210009, Jiangsu,China 2 Jiangsu Institute for Food and Drug Control,Nanjing 210008,Jiangsu,China

AIM:Essential hypertension is inherently associated with metabolic disorders,and its pathogenesis remains poorly *** of the metabolic perturbation of hypertension and the regulation of this perturbed metabolism using therapeutic agents can extend our insight into the pathogenesis of this ***:We used gas chromatography mass spectrometry and principal component analysis to profile the metabolic phenotype of hypertension in spontaneously hypertensive rats(SHR) and studied the regulatory effect of total ginsenosides(TG) and four typical antihypertensive agents on in vivo ***:The five agents yielded different hypotensive effects and distinct regulation patterns on the perturbed metabolism that occurs in ***,amlodipine,and terazosin efficiently depressed systolic blood pressure(SP) but had a negligible regulatory effect on the perturbed metabolism of SHR,even after the remission of hypertension for 8 *** finding suggests that hypertension may not be the cause of the metabolism perturbation observed in these *** contrast,TG gradually and markedly regulated the perturbed metabolism, and led to a mild but sustained depression of SP up to 2 weeks after the cessation of ***, TG downregulated free fatty acids(FFA) toward normal levels;the elevation of FFA correlates with blood pressure,in both animals and ***:These results suggest that TG may act as a special antihypertensive agent that regulates the perturbed metabolism of hypertension.

关键词： metabonomics hypertension total ginsenosides spontaneously hypertensive rats free fatty acids

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