Antihypertensive effects of total ginsenosides and regulation of the perturbed metabolism of spontaneously hypertensive rats
会议名称：《第九届全国药物和化学异物代谢学术会议》
会议日期：2009年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
关 键 词：metabonomics hypertension total ginsenosides spontaneously hypertensive rats free fatty acids
摘 要：AIM:Essential hypertension is inherently associated with metabolic disorders,and its pathogenesis remains poorly *** of the metabolic perturbation of hypertension and the regulation of this perturbed metabolism using therapeutic agents can extend our insight into the pathogenesis of this ***:We used gas chromatography mass spectrometry and principal component analysis to profile the metabolic phenotype of hypertension in spontaneously hypertensive rats(SHR) and studied the regulatory effect of total ginsenosides(TG) and four typical antihypertensive agents on in vivo ***:The five agents yielded different hypotensive effects and distinct regulation patterns on the perturbed metabolism that occurs in ***,amlodipine,and terazosin efficiently depressed systolic blood pressure(SP) but had a negligible regulatory effect on the perturbed metabolism of SHR,even after the remission of hypertension for 8 *** finding suggests that hypertension may not be the cause of the metabolism perturbation observed in these *** contrast,TG gradually and markedly regulated the perturbed metabolism, and led to a mild but sustained depression of SP up to 2 weeks after the cessation of ***, TG downregulated free fatty acids(FFA) toward normal levels;the elevation of FFA correlates with blood pressure,in both animals and ***:These results suggest that TG may act as a special antihypertensive agent that regulates the perturbed metabolism of hypertension.