检索结果-南通市图书馆

fate determination of fetal Leydig cells

Frontiers in Biology 2011年第1期6卷 12-18页

作者： Qing WEN Yixun LIU Fei GAO State Key Laboratory of Reproduction Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Graduate School of the Chinese Academy of Sciences Beijing 100049China

Leydig cell(LC)is one of the most important somatic cell types in testis,which localized in the interstitium between seminiferous *** major function of Leydig cells is to produce steroid hormone,*** differentiation exhibits a biphasic pattern in rodent testes,which are divided into two different temporal mature populations,fetal Leydig cells(FLCs)and adult Leydig cells(ALCs).FLCs are transiently present in fetal testes and undergo involution or degeneration after *** are completely devoid and replaced by ALCs in adult *** to ALCs,FLCs display unique morphology,ultrastructure and *** origin of FLCs has been debated for many years,but it is still a *** factors have been reported regulating the specification,proliferation and differentiation of *** degenerate in a few weeks postnatally,however,the underlying mechanism is still *** this review,we will focus on the fate determination of FLCs,and summarize the resent progress on the morphology,ultrastructure,function,origin and involution of FLCs.

关键词： fetal Leydig cells adult Leydig cells fate determination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Soxllb regulates the migration and fate determination of Müller glia-derived progenitors during retina regeneration in zebrafish

引用

Neural Regeneration Research 2023年第2期18卷 445-450页

作者： Kaida Song Zihao Lin Lining Cao Bowen Lu Yuxi Chen Shuqiang Zhang Jianfeng Lu Hui Xu Key Lab of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Shanghai YangZhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina

The transcription factor Sox11 plays important roles in retinal neurogenesis during vertebrate eye ***,its function in retina regeneration remains *** we report that Sox11 b,a zebrafish Sox11 homolog,regulates the migration and fate determination of Müller glia-derived progenitors(MGPCs)in an adult zebrafish model of mechanical retinal *** a stab injury,the expression of Sox11 b was induced in proliferating MGPCs in the ***11 b knockdown did not affect MGPC formation at 4 days post-injury,although the nuclear morphology and subsequent radial migration of MGPCs were alte *** 7 days post-injury,Sox11 b knockdown res ulted in an increased proportion of MGPCs in the inner retina and a decreased propo rtion of MGPCs in the outer nuclear layer,compared with ***,Sox11 b knockdown led to reduced photoreceptor regeneration,while it increased the numbe rs of newborn amacrines and retinal ganglion ***,quantitative polymerase chain reaction analysis revealed that Sox11 b regulated the expression of Notch signaling components in the retina,and Notch inhibition partially recapitulated the Sox11 b knockdown phenotype,indicating that Notch signaling functions downstream of Sox11 *** findings imply that Sox11 b plays key roles in MGPC migration and fate determination during retina regeneration in zebrafish,which may have critical im plications for future explorations of retinal repair in mammals.

关键词： cell migration fate determination Müllerglia Müller glia-derived progenitor Notch signaling photoreceptor retina regeneration Sox11 transcription factor zebrafish

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TGF-beta/Activin Signaling Determines the fate of Human Embryonic Stem Cell

TGF-beta/Activin Signaling Determines the Fate of Human Embr...

引用

中国细胞生物学学会第九次会员代表大会暨青年学术大会

作者：吴昭张炜成璐肖磊中国科学院上海生命科学研究院生物化学与细胞生物学研究所中国科学院细胞库/干细胞库

TGF-beta/activin signaling has been shown to be the key regulator in maintaining the pluripotency of human embryonic stem cells(hESCs).TGF-beta/activin signaling is necessary and sufficient to maintain the undifferent... 详细信息

关键词： TGF-beta/activin human ES cells fate determination

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Modulation of mouse embryonic stem cell fate by BMP

Modulation of mouse embryonic stem cell fate by BMP

引用

2012年中国科协海峡两岸青年科学家学术活动月——第九届海峡两岸细胞生物学学术研讨会

作者：陈晔光 The State Key Laboratory of Biomembrane and Membrane Biotechnology School of Life SciencesTsinghua University

Embryonic stem(ES)cells are under precise control of both intrinsic self-renewal gene regulatory network and extrinsic growth factor-triggered signaling *** external signaling pathways connect to intracellular regulat... 详细信息

关键词： BMP Embryonic stem cells DUSP9 ERK fate determination

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

FoxG1 Has a Cell-autonomous Role to Repress Medial Pallium-derived Cell fates during Early Telencephalic Development

FoxG1 Has a Cell-autonomous Role to Repress Medial Pallium-d...

引用

中国神经科学学会第十二届全国学术会议

作者： Xiao Han Xiao-Chun Gu Qian-Qian Zhang Jun-Hui Shen Qing-Xia Wang Yao Cheng Chunjie Zhao Key Laboratory of Developmental Genes and Human Diseases MOE School of Medicine Southeast University Center of Depression Beijing Institute for Brain Disorders

The dentate gyrus(DG) has important roles on learning and memory. However, how the fate of DG granule cells during early development determined is still far less clear. The forkhead box transcription factor Fox G1, usually serves as a transcriptional repressor and is thought to be involved in Rett syndrome, which is characterized by reduced hippocampus size, cognitive detects and severe mental retardation, indicating its important role in very early development of the DG. To further elucidate the mechanism of the DG cell fate determination, here we conditionally ablated Foxg1 in neural progenitor cells(NPCs) by crossing Foxg1 with Nestin-cre ER mice combined with tamoxifen induction. We have found that a small portion of cortical deep layer neuronsswitched their fates to CR cells when Foxg1 was deleted at the very early developmental stages. However a large portion of Foxg1-ablated deep layer neurons produced in the dorsal-lateral pallium adopted DG granule cell fates. Further studies in vivo and in vitro have shown that Fox G1 autonomously represses both CR cell and DG cell fates at the early developmental stages, and the suppression on CR cell fate is even much earlier. Our data will help to understand the mechanisms of how the telencephalic cell fate determined.

关键词： Foxg1 dentate gyrus Cajal-Retzius fate determination

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：