FoxG1 Has a Cell-autonomous Role to Repress Medial Pallium-derived Cell Fates during Early Telencephalic Development
作者单位：Key Laboratory of Developmental Genes and Human Diseases MOE School of Medicine Southeast University Center of Depression Beijing Institute for Brain Disorders
会议名称：《中国神经科学学会第十二届全国学术会议》
会议日期：2017年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：Foxg1 dentate gyrus Cajal-Retzius fate determination
摘 要：The dentate gyrus(DG) has important roles on learning and memory. However, how the fate of DG granule cells during early development determined is still far less clear. The forkhead box transcription factor Fox G1, usually serves as a transcriptional repressor and is thought to be involved in Rett syndrome, which is characterized by reduced hippocampus size, cognitive detects and severe mental retardation, indicating its important role in very early development of the DG. To further elucidate the mechanism of the DG cell fate determination, here we conditionally ablated Foxg1 in neural progenitor cells(NPCs) by crossing Foxg1 with Nestin-cre ER mice combined with tamoxifen induction. We have found that a small portion of cortical deep layer neuronsswitched their fates to CR cells when Foxg1 was deleted at the very early developmental stages. However a large portion of Foxg1-ablated deep layer neurons produced in the dorsal-lateral pallium adopted DG granule cell fates. Further studies in vivo and in vitro have shown that Fox G1 autonomously represses both CR cell and DG cell fates at the early developmental stages, and the suppression on CR cell fate is even much earlier. Our data will help to understand the mechanisms of how the telencephalic cell fate determined.