Fate determination of fetal Leydig cells

作     者：Qing WEN Yixun LIU Fei GAO 

作者机构：State Key Laboratory of Reproduction BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China Graduate School of the Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2011年第6卷第1期

页      面：12-18页

核心收录：

学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学] 

基　　金：the National Basic Research Program of China(“973”project)(No.2007CB947502) the CAS Innovation Project(No.KSCX2-YW-R-081) the National Nature Science Foundation of China(Grant No.31071271) 

主　　题：fetal Leydig cells adult Leydig cells fate determination 

摘      要：Leydig cell(LC)is one of the most important somatic cell types in testis,which localized in the interstitium between seminiferous *** major function of Leydig cells is to produce steroid hormone,*** differentiation exhibits a biphasic pattern in rodent testes,which are divided into two different temporal mature populations,fetal Leydig cells(FLCs)and adult Leydig cells(ALCs).FLCs are transiently present in fetal testes and undergo involution or degeneration after *** are completely devoid and replaced by ALCs in adult *** to ALCs,FLCs display unique morphology,ultrastructure and *** origin of FLCs has been debated for many years,but it is still a *** factors have been reported regulating the specification,proliferation and differentiation of *** degenerate in a few weeks postnatally,however,the underlying mechanism is still *** this review,we will focus on the fate determination of FLCs,and summarize the resent progress on the morphology,ultrastructure,function,origin and involution of FLCs.