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Recent progress and future directions of the research on nanoplastic-induced neurotoxicity

Neural Regeneration Research 2024年第2期19卷 331-335页

作者： Seung-Woo Han Jinhee Choi Kwon-Yul Ryu Department of Life Science University of SeoulSeoulSouth Korea School of Environmental Engineering University of SeoulSeoulSouth Korea

Many types of plastic products,including polystyrene,have long been used in commercial and industrial *** and nanoplastics,plastic particles derived from these plastic products,are emerging as environmental pollutants that can pose health risks to a wide variety of living organisms,including ***,it is not well understood how microplastics and nanoplastics affect cellular functions and induce stress *** can be exposed to polystyrene-microplastics and polystyrene-nanoplastics through ingestion,inhalation,or skin *** ingested plastics are excreted from the body,but inhaled plastics may accumulate in the lungs and can even reach the brain via the nose-to-brain ***-sized polystyrene-nanoplastics can enter cells by endocytosis,accumulate in the cytoplasm,and cause various cellular stresses,such as inflammation with increased pro-inflammatory cytokine production,oxidative stress with generation of reactive oxygen species,and mitochondrial *** induce autophagy activation and autophagosome formation,but autophagic flux may be impaired due to lysosomal *** permanently exposed to polystyrene-nanoplastics,they can be removed from cells by exocytosis and subsequently restore cellular ***,neurons are very susceptible to this type of stress,thus even acute exposure can lead to neurodegeneration without *** review focuses specifically on recent advances in research on polystyrene-nanoplastic-induced cytotoxicity and ***,in this review,based on mechanistic studies of polystyrene-nanoplastics at the cellular level other than neurons,future directions for overcoming the negative effects of polystyrene-nanoplastics on neurons were suggested.

关键词： autophagy cellular stress cytotoxicity endocytosis exocytosis inflammation microplastics nanoplastics neurotoxicity oxidative stress polystyrene

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New aspects of a small GTPase RAB35 in brain development and function

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Neural Regeneration Research 2025年第7期20卷 1971-1980页

作者： Ikuko Maejima Ken Sato Laboratory of Molecular Traffic Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or *** processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS *** of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative ***,it is important to understand the physiological and pathological roles of RAB proteins in brain ***35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell ***35 is also involved in neurite outgrowth and turnover of synaptic *** generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and *** mice exhibited defects in anxiety-related behaviors and spatial ***,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal *** contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex *** studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's *** this review,we provide an overview of the current understanding of subcellular functions of *** also provide insights into the phys

关键词： endocytosis endosomes hippocampal development neurodegenerative diseases RAB35

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Effect of Tb/Mg doping on composition and physical properties of hydroxyapatite nanoparticles for gene vector application

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Transactions of Nonferrous Metals Society of China 2018年第1期28卷 125-136页

作者： Liang-jian CHEN Tian CHEN Jun CAO Bei-lei LIU Chun-sheng SHAO Ke-chao ZHOU Dou ZHANG Department of Stomatology Third Xiangya Hospital Central South University Changsha 410013 China State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China Xiangya School of Medicine Central South University Changsha 410013 China

Transfection efficiency of hydroxyapatite nanoparticles(HAnps)is relative to the particle size,morphology,surface charge,surface modifier and so *** study prepared HAnps with doped Tb/Mg by hydrothermal synthesis method(HTSM)and investigated the effects of different Tb/Mg contents on the morphology,particle size,surface charge,composition and cellular endocytosis of *** results showed that Mg-HAnps possessed better dispersion ability than *** increasing doping content of Tb/Mg-HAnps,the granularity of Tb-HAnps increased,while that of Mg-HAnps *** particle size and zeta potential of Mg-HAnps were lower than those of Tb-HAnps.7.5%Mg-doping HAnps presented relatively uniform slender rod morphology with average size of30nm,while10%Mg-doping HAnps were prone to ***,Mg-HAnps-GFP(green fluorescent protein)endocytosed by MG63cells was dotted in the perinuclear region,while Tb-HAnps were more likely to *** conclusion,as gene vectors,Mg-HAnps showed enhanced properties compared to Tb-HAnps.

关键词： hydroxyapatite nanoparticles gene vector endocytosis doping fluorescence labeling

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Research on GGT-responsive drug carrier with active transport effect

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Nano Research 2023年第5期16卷 7075-7084页

作者： Han Yan He Ma Bin He Bing Yu Youqing Shen Hailin Cong Institute of Biomedical Materials and Engineering College of Materials Science and EngineeringCollege of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao 266071China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for BionanoengineeringDepartment of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China School of Materials Science and Engineering Shandong University of TechnologyZibo 255000China

Although a great quantity research has been done on cancer nano-drug carriers,how to deliver more cancer nano-drugs to tumor sites accurately and then endocytosis by cells is still a key problem in the process of cancer *** the concentration ofγ-glutamyl transpeptidase(GGT)in the microenvironment will be greatly increased when the liver,kidney,other organs become cancerous,we have designed a polymer nanomicelle as drug carrier that can respond to the GGT in the tumor *** the drug delivery system participates in blood circulation through the vascular wall cells to the tumor tissue,the overexpressed GGT on the surface of the cancer cells will recognize and cut theγ-glutamyl group on the carrier,the primary amines will be released to make the system with weak positive charge,which not only improves the carrier’s active transport ability for nanodrugs,but also improves the cell’s endocytosis ability for nano-drugs,so as to realize the release of nano-drugs in cancer ***’s more,the positive charge on the surface of the carrier also improves the permeability of the carrier in the tumor tissue,so that the cancer cells in the hypoxic area can also endocytosis drugs.

关键词： micelles enzyme response active transport endocytosis

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Surface chemistry of carbon nanoparticles functionally select their uptake in various stages of cancer cells

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Nano Research 2017年第10期10卷 3269-3284页

作者： Indrajit Srivastava Santosh K. Misra Fatemeh Ostadhossein Enrique Daza Jasleena Singh Dipanjan Pan Department of Bioengineering University of Illinois Urbana-Champaign Urbana Illinois 61801 USA Biomedical Research Center Carle Foundation Hospital Urbana Illinois 61801 USA Department of Materials Science and Beckman Institute University of illinois Urbana-Champaign Urbana Illinois 61801 USA

Relationship of the surface physicochemical characteristics of nanoparticles with their interactions with biological entities may provide critical information for nanomedicinal application. Here, we report the systematic synthesis of sub-50 nm carbon nanoparticles （CNP） presenting neutral, anionic, and cationic surface functionalities. A subset of CNPs with -10, 20, and 40 nm hydrodynamic sizes were synthesized with neutral surface headgroups. For the first time, the cellular internalization of these CNPs was systematically quantified in various stages of breast cancer cells （early, late, and metastatic）, thereby providing a parametric assessment of charge and size effects. Distinct activities were observed when these systems interacted with cancer cells in various stages. Our results indicated that metastatic breast cancer could be targeted by a nanosystem presenting anionic phosphate groups. On the contrary, for patients in late stage of cancer, drugs could be delivered with sulfonate functionalized carbon nano- particles, which have higher probability of intracellular transport. This study will facilitate the better understanding of nanoparticle-biological entity interaction, and the integration of this knowledge with pathophysiology would promote the engineering of nanomedicine with superior likelihoods of crossing the endocytic ＂barrier＂ for drug delivery inside cancerous cells.

关键词： personalized medicine endocytosis surface charge size carbon nanoparticles

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Benidipine-loaded nanoflower-likemagnesium silicate improves bone regeneration

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生物设计与制造(英文) 2023年第5期6卷 507-521页

作者： Jingyi Lu Miao Sun Jingyu Zhang Xiaofu Yang Minyi Dong Huihui He An Liu Mengfei Yu Baixiang Wang Huiming Wang The Affiliated Hospital of Stomatology School of StomatologyZhejiang University School of MedicineHangzhou 310000China Key Laboratory of Oral Biomedical Research of Zhejiang Province Hangzhou 310000China Department of Orthopedics The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Orthopedics Research Institute of Zhejiang University Hangzhou 310009China Zhangjiagang Hospital of Traditional Chinese Medicine Suzhou 215600China

Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on ***,we propose a novel strategy combining benidipine,an antihypertensive drug and nanoparticles to synergistically promote the healing of bone *** and porous benidipine-loaded magnesium silicate nanoparticles were prepared and validated for their *** nanoparticles were efficiently taken up by preosteoblasts and uniformly distributed around the *** internalization into cells,the nanosystem is degraded by lysosomes,and the effect of promoting osteogenic differentiation is reflected by the continuous release of benidipine,silicon and magnesium *** results clearly evaluated that the nanoflower-like magnesium silicate delivering benidipine tends to be more appropriate for the bone regeneration in preosteoblasts,indicating that it might be a potential approach in guiding bone repair in clinical applications.

关键词： Nanoparticles Benidipine Bone tissueengineering endocytosis

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Transportation of AIE-visualized nanoliposomes is dominated by the protein corona

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National Science Review 2021年第6期8卷 23-33页

作者： Yi-Feng Wang Chunqiu Zhang Keni Yang Yufei Wang Shaobo Shan Yan Yan Kenneth A.Dawson Chen Wang Xing-Jie Liang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of China University of Chinese Academy of Sciences State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials of Ministry of Educationand College of Life SciencesNankai University Centre for Bio Nano Interactions School of ChemistryUniversity College Dublin School of Biomolecular and Biomedical Science University College Dublin Guangdong Provincial Education Department Key Laboratory of Nano-Immuno-regulation Tumor Microenvironment The Second Affiliated HospitalGuangzhou Medical University

Liposomes, especially cationic liposomes, are the most common and well-investigated nanocarriers for biomedical applications, such as drug and gene delivery. Like other types of nanomaterials, once liposomes are incubated in a biological milieu, their surface can be immediately cloaked by biological components to form a protein corona, which confers a new ‘biological identity’ and modulates downstream interactions with cells. However, it remains unclear how the protein corona affects the transportation mechanism after liposomes interact with cells. Here, we employed home-made aggregation-induced-emission-visualized nanoliposomes TR4@Lipo as a model to investigate transportation with or without the protein corona by optical imaging techniques. The results show that the protein corona can change the cellular transportation mechanism of TR4@Lipo from energy-independent membrane fusion to energy-dependent *** protein corona also modulates the intracellular distribution of loaded cargoes. This knowledge furthers our understanding of bio-nano interactions and is important for the efficient use of cationic liposomes.

关键词： aggregation-induced emission (AIE) cationic liposomes protein corona endocytosis membrane fusion

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A Novel Gene Delivery System Targeting Urokinase Receptor

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Acta Biochimica et Biophysica Sinica 2004年第7期36卷 485-491页

作者： Xing-Hui SUN, Li TAN, Chun-Yang LI, Chang TONG, Jin FAN, Ping LI, and Yun-Song ZHU*Department of Molecular Genetics, Key Laboratory of Molecular Medicine of Ministry Education,Shanghai Medical College of Fudan University, Shanghai 200032, China Department of Molecular Genetics Key Laboratory of Molecular Medicine of Ministry Education Shanghai Medical College of Fudan UniversityShanghai 200032 China

Recombinant proteins that combine different functions required for cell targeting and intra- cellular delivery of DNA present an attractive approach for the development of nonviral gene delivery vectors. Here, we described a novel protein termed ATF-lys10 which facilitated cell-specific gene transfer via receptor-mediated endocytosis. ATF-lys10 was composed of the amino-terminal fragment of urokinase and ten lysines at the carboxyl terminus. Bacterially expressed ATF-lys10 protein existed in soluble form, and had antigenicity of human urokinase. Purified ATF-lys10 specifically bound to uPAR-expressing cells and formed protein-DNA complexes with plasmid pGL3-control. After neutralization of excess negative charge with poly-L-lysine, these complexes served as a specific gene delivery vector for uPAR-expressing cells. Lyso- somotropic compounds, such as chloroquine, drastically increased the ATF-lys10 mediated gene delivery efficiency. Our results suggest that the recombinant protein ATF-lys10 with the properties of DNA binding and tumor cell targeting represents a promising method for gene transfer and expression in tumor cells.

关键词： amino-terminal fragment urokinase gene transfer endocytosis urokinase receptor

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Metabolic profile of chiral cobalt oxide nanoparticles in vitro and in vivo

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Nano Research 2021年第7期14卷 2451-2455页

作者： Si Li Liwei Xu Meiru Lu Maozhong Sun Liguang Xu Changlong Hao Xiaoling Wu Chuanlai Xu Hua Kuang International Joint Research Laboratory for Biointerface and Biodetection Jiangnan UniversityWuxi 214122China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China

In this study,we investigated the in vivo behaviors of chiral cobalt oxide nanoparticles(Co_(3)O_(4) NPs)stabilized with D-or L-cysteine(denoted D-or L-NPs,respectively),as representative chiral metal oxide *** Co_(3)O_(4) NPs exerted no observable cytotoxicity within the tested dose *** D-NPs and L-NPs were internalized by dendritic cells through caveola-dependent endocytosis,and L-NPs entered the cells faster than ***,a metabolic analysis indicated that chiral L-NPs had the same effect on the level of bile acids in the liver as D-NPs,which is attributed to the almost equal amount of farnesoid X receptor(FXR)induced by the chiral *** study suggests that low chiroptical activity nanomaterials would not affect the metabolism and kinetics under physiological conditions even if there is some difference in their transport.

关键词： chiral metal oxide endocytosis bile acid metabolism

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Salicylic Acid Regulates Pollen Tip Growth ：hrough an NPR3/NPR4-1ndependent Pathway

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Molecular Plant 2016年第11期9卷 1478-1491页

作者： Duoyan Rong Nan Luo Jean Claude Mollet Xuanming Liu Zhenbiao Yang State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation College of Biology Hunan University Changsha 410082 China Department of Botany and Plant Sciences and Center for Plant Cell Biology Institute of Integrated Genome Biology University of California Riverside CA 92521 USA Normandie Univ UniRouen Laboratoire Glycobiologie et Matrice Extracellulaire V6getale Institute for Research and Innovation in Biomedicine Vegetal Agronomie Sol et Innovation 76821 Mont-Saint-Aignan France

Tip growth is a common strategy for the rapid elongation of cells to forage the environment and/or to target to long-distance destinations. In the model tip growth system of Arabidopsis pollen tubes, several small- molecule hormones regulate their elongation, but how these rapidly diffusing molecules control extremely localized growth remains mysterious. Here we show that the interconvertible salicylic acid （SA） and meth- ylated SA （MESA）, well characterized for their roles in plant defense, oppositely regulate Arabidopsis pollen tip growth with SA being inhibitory and MeSA stimulatory. The effect of SA and MeSA was independent of known NPR3/NPR4 SA receptor-mediated signaling pathways. SA inhibited clathrin-mediated endocytosis in pollen tubes associated with an increased accumulation of less stretchable demethylated pectin in the apical wall, whereas MeSA did the opposite. Furthermore, SA and MeSA alter the apical activation of ROP1 GTPase, a key regulator of tip growth in pollen tubes, in an opposite manner. Interestingly, both MeSA methylesterase and SA methyltransferase, which catalyze the interconversion between SA and MESA, are localized at the apical region of pollen tubes, indicating of the tip-localized production of SA and MeSA and consistent with their effects on the apical cellular activities. These findings suggest that local generation of a highly diffusible signal can regulate polarized cell growth, providing a novel mechanism of cell polarity control apart from the one involving protein and mRNA polarization.

关键词： SA (salicylic acid) MeSA (methyl salicylic acid) endocytosis FM4-64 CRIB4-GFP ROP activity

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