Benidipine-loaded nanoflower-likemagnesium silicate improves bone regeneration

作     者：Jingyi Lu Miao Sun Jingyu Zhang Xiaofu Yang Minyi Dong Huihui He An Liu Mengfei Yu Baixiang Wang Huiming Wang Jingyi Lu;Miao Sun;Jingyu Zhang;Xiaofu Yang;Minyi Dong;Huihui He;An Liu;Mengfei Yu;Baixiang Wang;Huiming Wang

作者机构：The Affiliated Hospital of StomatologySchool of StomatologyZhejiang University School of MedicineHangzhou 310000China Key Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhou 310000China Department of OrthopedicsThe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Orthopedics Research Institute of Zhejiang UniversityHangzhou 310009China Zhangjiagang Hospital of Traditional Chinese MedicineSuzhou 215600China 

出 版 物：《生物设计与制造(英文)》 (Bio-Design and Manufacturing)

年 卷 期：2023年第6卷第5期

页      面：507-521页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China(Nos.8212200044,82071085,31872752,and 81600909) the Zhejiang Provincial Natu-ral Science Foundation of China(Nos.LR21H140001,LY22H140002,and LQ22C100003) the National Key Research and Development Pro-gram of China(No.2018YFA0703000) the Medical Technology and Education of Zhejiang Province of China(No.2018KY501) 

主　　题：Nanoparticles Benidipine Bone tissueengineering Endocytosis 

摘      要：Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on ***,we propose a novel strategy combining benidipine,an antihypertensive drug and nanoparticles to synergistically promote the healing of bone *** and porous benidipine-loaded magnesium silicate nanoparticles were prepared and validated for their *** nanoparticles were efficiently taken up by preosteoblasts and uniformly distributed around the *** internalization into cells,the nanosystem is degraded by lysosomes,and the effect of promoting osteogenic differentiation is reflected by the continuous release of benidipine,silicon and magnesium *** results clearly evaluated that the nanoflower-like magnesium silicate delivering benidipine tends to be more appropriate for the bone regeneration in preosteoblasts,indicating that it might be a potential approach in guiding bone repair in clinical applications.