Metabolic profile of chiral cobalt oxide nanoparticles in vitro and in vivo
作者机构：International Joint Research Laboratory for Biointerface and BiodetectionJiangnan UniversityWuxi 214122China State Key Laboratory of Food Science and TechnologyJiangnan UniversityWuxi 214122China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2021年第14卷第7期
页 面：2451-2455页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：This work is financially supported by the National Natural Science Foundation of China(Nos.21874058,51802125,51902136,21771090,31771084,21631005,and 21673104) the Fundamental Research Funds for the Central Universities(No.JUSRP12003)
主 题：chiral metal oxide endocytosis bile acid metabolism
摘 要：In this study,we investigated the in vivo behaviors of chiral cobalt oxide nanoparticles(Co_(3)O_(4) NPs)stabilized with D-or L-cysteine(denoted D-or L-NPs,respectively),as representative chiral metal oxide *** Co_(3)O_(4) NPs exerted no observable cytotoxicity within the tested dose *** D-NPs and L-NPs were internalized by dendritic cells through caveola-dependent endocytosis,and L-NPs entered the cells faster than ***,a metabolic analysis indicated that chiral L-NPs had the same effect on the level of bile acids in the liver as D-NPs,which is attributed to the almost equal amount of farnesoid X receptor(FXR)induced by the chiral *** study suggests that low chiroptical activity nanomaterials would not affect the metabolism and kinetics under physiological conditions even if there is some difference in their transport.
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