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A flexible electrode array for determining regions of motor function activated by epidural spinal cord stimulation in rats with spinal cord injury

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Neural Regeneration Research 2022年第3期17卷 601-607页

作者： Guang-Wei Mao Jian-Jun Zhang Hao Su Zhi-Jun Zhou Lin-Sen Zhu Xiao-Ying Lü Zhi-Gong Wang State Key Laboratory of Bioelectronics Southeast UniversityNanjingJiangsu ProvinceChina Institute of RF-&OE-ICs Southeast UniversityNanjingJiangsu ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

Epidural stimulation of the spinal cord is a promising technique for the recovery of motor function after spinal cord *** key challenges within the reconstruction of motor function for paralyzed limbs are the precise control of sites and parameters of *** activate lower-limb muscles precisely by epidural spinal cord stimulation,we proposed a high-density,flexible electrode *** determined the regions of motor function that were activated upon epidural stimulation of the spinal cord in a rat model with complete spinal cord,which was established by a transection *** evaluating the effect of stimulation,the evoked potentials were recorded from bilateral lowerlimb muscles,including the vastus lateralis,semitendinosus,tibialis anterior,and medial *** determine the appropriate stimulation sites and parameters of the lower muscles,the stimulation characteristics were studied within the regions in which motor function was activated upon spinal cord *** the vastus lateralis and medial gastrocnemius,these regions were symmetrically located at the lateral site of L1 and the medial site of L2 vertebrae segment,*** tibialis anterior and semitendinosus only responded to stimulation simultaneously with other *** minimum and maximum stimulation threshold currents of the vastus lateralis were higher than those of the medial *** results demonstrate the ability to identify specific stimulation sites of lower muscles using a high-density and flexible *** also provide a reference for selecting the appropriate conditions for implantable stimulation for animal models of spinal cord *** study was approved by the Animal Research Committee of Southeast University,China(approval No.20190720001) on July 20,2019.

关键词： electrode array epidural spinal cord stimulation evoked potentials motor function rehabilitation spinal cord injury spinal segment

Research software in cochlear duct length estimation,Greenwood frequency mapping and CI electrode array length simulation

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第1期7卷 17-22页

作者： Dhanasingh Anandhan MED-EL GmbH Furstenweg 77a6020InnsbruckAustria

Background and objective:The size of the cochlea varies a lot among the human population bringing the necessity for electrode arrays to be available in various lengths irrespective of the cochlear implant(CI)*** research software helps in the estimation of the patient’s cochlear duct length(CDL)which is then used for the simulation of the correct length electrode array matching the patient’s cochlear size and as well in getting the patient specific cochlear frequency ***:Visual Studio Express 2012 for Windows Desktop is used in the architecture of this research *** basal turn diameter of the cochlea("A"value)needs to be measured from the pre-operative computed tomography(CT)image of the patient’s temporal ***"A"will be taken as the input for the CDL equations proposed by Alexiades et al for estimating the CDL along the basilar membrane for various insertion ***’s equation is then used in combination with the CDL for the full length of the cochlea in getting the patient specific frequency ***:The research software with the help of the"A"value as input,with few button clicks,gives the patient specific CDL for various insertion depths and the Greenwood’s frequency *** users have the choice to select any electrode array of their choice and place it under the frequency map to see how good it fits to that particular patient’s ***,given the possibility to drag and move the electrode array picture to mimic the post-operative actual electrode insertion ***:This research software simplifies the overall process of CDL estimation and in getting the patient specific cochlear frequency *** clinicians get the chance to simulate placing the various electrode array lengths in patient cochlea in identifying the best fit *** could help in pushing the CI field into the concept of individualized CI electrode array solution that ultimately benefits the patients.

关键词： Cochlear duct length Greenwood frequency map electrode array

Automatic decomposition of pediatric high density surface EMG:A pilot study

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Medicine in Novel Technology and Devices 2021年第4期12卷 50-54页

作者： Maoqi Chen Ping Zhou University of Health and Rehabilitation Sciences QingdaoChina

This pilot study presents a novel application of high density surface electromyography(EMG)decomposition in pediatric patients,with a view toward promoting its potential clinical application for examination of pediatricneuromuscular *** progressive FastICA peel-off(APFP)framework was used to decompose high density surface EMG signals recorded from the first dorsal interosseous and abductor pollicis brevis muscles ofchildren with spinal muscular *** performance of the decomposition with reduced EMG recordingchannels was also *** total 131 motor units were extracted from 15 trials of 64-channel(8×8)surface *** decomposition yield reduced to 102 motor units when 36-channel(6×6)was used,amongwhich 84 motor units were common ones with an average matching rate of(95.68±5.26)%.The decompositionyield further reduced to 65 motor units when only 16-channel(4×4)was used,among which 57 were common ones with an average matching rate of(95.99±4.56)%.These results indicate that using the APFP frameworksingle motor unit activity can be reliably and automatically extracted from pediatric surface EMG signals recordedby an electrode array,which can facilitate potential clinical application of surface EMG as an alternative or supplement to invasive needle EMG for examination of neuromuscular diseases in children.

关键词： Electromyography(EMG) Pediatric EMG Surface EMG decomposition Spinal muscular atrophy electrode array Automatic progressive FastICA peel-off

Cutaneous sensory nerve as a substitute for auditory nerve in solving deaf-mutes' hearing problem: an innovation in multi-channel-array skin-hearing technology

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Neural Regeneration Research 2014年第16期9卷 1532-1540页

作者： Jianwen Li Yan Li Ming Zhang Weifang Ma Xuezong Ma College of Electric & Information Engineering Shaanxi University of Science & Technology Skin-Hearing Research Institute Shaanxi University of Science & Technology Library of Shaanxi University of Science & Technology College of Computer Science Xi’an Polytechnic University

The current use of hearing aids and artificial cochleas for deaf-mute individuals depends on their auditory nerve. Skin-hearing technology, a patented system developed by our group, uses a cutaneous sensory nerve to substitute for the auditory nerve to help deaf-mutes to hear sound. This paper introduces a new solution, multi-channel-array skin-hearing technology, to solve the problem of speech discrimination. Based on the filtering principle of hair cells, external voice sig- nals at different frequencies are converted to current signals at corresponding frequencies using electronic multi-channel bandpass filtering technology. Different positions on the skin can be stimulated by the electrode array, allowing the perception and discrimination of external speech signals to be determined by the skin response to the current signals. Through voice frequen- cy analysis, the frequency range of the band-pass filter can also be determined. These findings demonstrate that the sensory nerves in the skin can help to transfer the voice signal and to dis- tinguish the speech signal, suggesting that the skin sensory nerves are good candidates for the replacement of the auditory nerve in addressing deaf-mutes＇ hearing problems. Scientific hearing experiments can be more safely performed on the skin. Compared with the artificial cochlea, multi-channel-array skin-hearing aids have lower operation risk in use, are cheaper and are more easily popularized.

关键词： nerve regeneration peripheral nerve skin-hearing multi-channel electrode array aid deaf band-pass filter voice NSFC grant neural regeneration